Search Results - "Brivanlou, Ali H."

Embryoids, organoids and gastruloids: new approaches to understanding embryogenesis by Simunovic, Mijo, Brivanlou, Ali H

“…Cells have an intrinsic ability to self-assemble and self-organize into complex and functional tissues and organs. By taking advantage of this ability,…”
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A Balance between Secreted Inhibitors and Edge Sensing Controls Gastruloid Self-Organization by Etoc, Fred, Metzger, Jakob, Ruzo, Albert, Kirst, Christoph, Yoney, Anna, Ozair, M. Zeeshan, Brivanlou, Ali H., Siggia, Eric D.

“…The earliest aspects of human embryogenesis remain mysterious. To model patterning events in the human embryo, we used colonies of human embryonic stem cells…”
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A method to recapitulate early embryonic spatial patterning in human embryonic stem cells by Warmflash, Aryeh, Sorre, Benoit, Etoc, Fred, Siggia, Eric D, Brivanlou, Ali H

“…This paper demonstrates that micropatterned human embryonic stem cell colonies can acquire spatial patterns reminiscent of those in the embryo and proposes…”
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The BMP Inhibitor Coco Reactivates Breast Cancer Cells at Lung Metastatic Sites by Gao, Hua, Chakraborty, Goutam, Lee-Lim, Ai Ping, Mo, Qianxing, Decker, Markus, Vonica, Alin, Shen, Ronglai, Brogi, Edi, Brivanlou, Ali H., Giancotti, Filippo G.

“…The mechanistic underpinnings of metastatic dormancy and reactivation are poorly understood. A gain-of-function cDNA screen reveals that Coco, a secreted…”
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Self-organization of the in vitro attached human embryo by Deglincerti, Alessia, Croft, Gist F., Pietila, Lauren N., Zernicka-Goetz, Magdalena, Siggia, Eric D., Brivanlou, Ali H.

“…An in vitro model to study the early events that direct human embryo development after formation of the blastocyst and implantation in the uterine wall…”
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A regulatory circuitry comprised of miR-302 and the transcription factors OCT4 and NR2F2 regulates human embryonic stem cell differentiation by Rosa, Alessandro, Brivanlou, Ali H

“…Multiple levels of control are in play to regulate pluripotency and differentiation in human embryonic stem cells (hESCs). At the transcriptional level, the…”
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Depletion of aneuploid cells in human embryos and gastruloids by Yang, Min, Rito, Tiago, Metzger, Jakob, Naftaly, Jeffrey, Soman, Rohan, Hu, Jianjun, Albertini, David F., Barad, David H., Brivanlou, Ali H., Gleicher, Norbert

“…Chromosomal instability leading to aneuploidy is pervasive in early human embryos 1 – 3 and is considered as a major cause of infertility and pregnancy wastage…”
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The ethics of human-embryoids model: a call for consistency by Nicolas, Paola, Etoc, Fred, Brivanlou, Ali H.

“…In this article, we discuss the ethics of human embryoids, i.e., embryo-like structures made from pluripotent stem cells for modeling natural embryos. We argue…”
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The evolution of our understanding of human development over the last 10 years by Brivanlou, Ali H., Gleicher, Norbert

“…As it fulfills an irresistible need to understand our own origins, research on human development occupies a unique niche in scientific and medical research. In…”
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Encoding of Temporal Signals by the TGF-β Pathway and Implications for Embryonic Patterning by Sorre, Benoit, Warmflash, Aryeh, Brivanlou, Ali H., Siggia, Eric D.

“…Genetics and biochemistry have defined the components and wiring of the signaling pathways that pattern the embryo. Among them, the transforming growth factor…”
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Combined small-molecule inhibition accelerates the derivation of functional cortical neurons from human pluripotent stem cells by Qi, Yuchen, Zhang, Xin-Jun, Renier, Nicolas, Wu, Zhuhao, Atkin, Talia, Sun, Ziyi, Ozair, M Zeeshan, Tchieu, Jason, Zimmer, Bastian, Fattahi, Faranak, Ganat, Yosif, Azevedo, Ricardo, Zeltner, Nadja, Brivanlou, Ali H, Karayiorgou, Maria, Gogos, Joseph, Tomishima, Mark, Tessier-Lavigne, Marc, Shi, Song-Hai, Studer, Lorenz

“…Cortical neurons are rapidly derived from human pluripotent stem cells using a cocktail of small molecules. Considerable progress has been made in converting…”
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Self-organization of human embryonic stem cells on micropatterns by Deglincerti, Alessia, Etoc, Fred, Guerra, M Cecilia, Martyn, Iain, Metzger, Jakob, Ruzo, Albert, Simunovic, Mijo, Yoney, Anna, Brivanlou, Ali H, Siggia, Eric, Warmflash, Aryeh

“…This protocol describes how to differentiate and image human embryonic stem cells on micropatterned colonies to create radially organized domains of the germ…”
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Self-organization of human dorsal-ventral forebrain structures by light induced SHH by De Santis, Riccardo, Etoc, Fred, Rosado-Olivieri, Edwin A., Brivanlou, Ali H.

“…Organizing centers secrete morphogens that specify the emergence of germ layers and the establishment of the body’s axes during embryogenesis. While…”
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The miR-430/427/302 Family Controls Mesendodermal Fate Specification via Species-Specific Target Selection by Rosa, Alessandro, Spagnoli, Francesca M., Brivanlou, Ali H.

“…The role of microRNAs in embryonic cell fate specification is largely unknown. In vertebrates, the miR-430/427/302 family shows a unique expression signature…”
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How will our understanding of human development evolve over the next 10 years by Brivanlou, Ali H., Rivron, Nicolas, Gleicher, Norbert

“…In the next 10 years, the continued exploration of human embryology holds promise to revolutionize regenerative and reproductive medicine with important…”
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Signaling pathways in cancer and embryonic stem cells by Dreesen, Oliver, Brivanlou, Ali H

“…Cancer cells have the ability to divide indefinitely and spread to different parts of the body during metastasis. Embryonic stem cells can self-renew and,…”
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APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex by Shimomura, Yutaka, Agalliu, Dritan, Vonica, Alin, Luria, Victor, Wajid, Muhammad, Baumer, Alessandra, Belli, Serena, Petukhova, Lynn, Schinzel, Albert, Brivanlou, Ali H., Barres, Ben A., Christiano, Angela M.

“…The routes of hair growth Hair follicle miniaturization is a degenerative process that reduces the dimensions of the epithelial and mesenchymal cell…”
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WNT signaling memory is required for ACTIVIN to function as a morphogen in human gastruloids by Yoney, Anna, Etoc, Fred, Ruzo, Albert, Carroll, Thomas, Metzger, Jakob J, Martyn, Iain, Li, Shu, Kirst, Christoph, Siggia, Eric D, Brivanlou, Ali H

“…Self-organization of discrete fates in human gastruloids is mediated by a hierarchy of signaling pathways. How these pathways are integrated in time, and…”
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Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor by Brivanlou, Ali H, Sato, Noboru, Meijer, Laurent, Skaltsounis, Leandros, Greengard, Paul

“…Human and mouse embryonic stem cells (HESCs and MESCs, respectively) self-renew indefinitely while maintaining the ability to generate all three germ-layer…”
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Dynamics of TGF-β signaling reveal adaptive and pulsatile behaviors reflected in the nuclear localization of transcription factor Smad4 by Warmflash, Aryeh, Zhang, Qixiang, Sorre, Benoit, Vonica, Alin, Siggia, Eric D, Brivanlou, Ali H

“…The TGF-β pathway plays a vital role in development and disease and regulates transcription through a complex composed of receptor-regulated Smads (R-Smads)…”
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