Search Results - "Britton, Zachary T."

Recombinant protein expression and purification: A comprehensive review of affinity tags and microbial applications by Young, Carissa L., Britton, Zachary T., Robinson, Anne S.

“…Protein fusion tags are indispensible tools used to improve recombinant protein expression yields, enable protein purification, and accelerate the…”
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Generating therapeutic monoclonal antibodies to complex multi-spanning membrane targets: Overcoming the antigen challenge and enabling discovery strategies by Dodd, Roger, Schofield, Darren J., Wilkinson, Trevor, Britton, Zachary T.

“…•G protein-coupled receptors, ion channels and transporters, are important targets for drug discovery.•Monoclonal antibodies and related molecules may…”
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Improved ligand-binding- and signaling-competent human NK2R yields in yeast using a chimera with the rat NK2R C-terminus enable NK2R-G protein signaling platform by Jain, Abhinav R, Britton, Zachary T, Markwalter, Chester E, Robinson, Anne S

“…The tachykinin 2 receptor (NK2R) plays critical roles in gastrointestinal, respiratory and mental disorders and is a well-recognized target for therapeutic…”
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Tag-on-Demand: exploiting amber codon suppression technology for the enrichment of high-expressing membrane protein cell lines by Britton, Zachary T, London, Timothy B, Carrell, Jeffrey, Dosanjh, Bhupinder, Wilkinson, Trevor, Bowen, Michael A, Wu, Herren, Dall'Acqua, William F, Marelli, Marcello, Mazor, Yariv

“…Abstract Membrane proteins play key roles in the evolution of numerous diseases and as a result have become the most dominant class of targets for therapeutic…”
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High-level expression in Saccharomyces cerevisiae enables isolation and spectroscopic characterization of functional human adenosine A2a receptor by O'Malley, Michelle A, Lazarova, Tzvetana, Britton, Zachary T, Robinson, Anne S

“…The G-protein coupled receptors (GPCRs) are a class of membrane proteins that trigger cellular responses to external stimuli, and are believed to be targets…”
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Recombinant G protein-coupled receptor expression in Saccharomyces cerevisiae for protein characterization by Blocker, Kory M, Britton, Zachary T, Naranjo, Andrea N, McNeely, Patrick M, Young, Carissa L, Robinson, Anne S

“…G protein-coupled receptors (GPCRs) are membrane proteins that mediate signaling across the cellular membrane and facilitate cellular responses to external…”
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An expression and purification system for the biosynthesis of adenosine receptor peptides for biophysical and structural characterization by Britton, Zachary T., Hanle, Elizabeth I., Robinson, Anne S.

“…► Novel expression and purification system for transmembrane domain peptides developed. ► Cleavage strategy utilizes thrombin processing and eliminates the…”
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Healing and normal fibroblasts exhibit differential proliferation, collagen production, alpha-SMA expression, and contraction by Agarwal, Charu, Britton, Zachary T, Alaseirlis, Dimosthenis A, Li, Yunxia, Wang, James H-C

“…This study determines the differences in proliferation, collagen production, alpha-smooth muscle actin (alpha-SMA) expression, and contraction between healing…”
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Preclinical Evaluation of AZD6422, an Armored Chimeric Antigen Receptor T Cell Targeting CLDN18.2 in Gastric, Pancreatic, and Esophageal Cancers by Barrett, Allison M., Britton, Zachary T., Carrasco, Rosa A., Breen, Shannon, Broggi, Maria A.S., Hatke, Amanda L., Clark, Benjamin, Yang, Chunning, Phipps, Sandrina, Ortiz, Lorenzo, Janocha, Brianna, Zanvit, Peter, Giraldo, Nicolas A., Martin, Philip L., Lapointe, Jean-Martin, Harder, Nathalie, Cornish, Georgina H., Attili, Bala N.N.R., Mazor, Yariv, Damschroder, Melissa, Cobbold, Mark, Moody, Gordon, Bosco, Emily E.

“…Abstract Purpose: Claudin 18.2 (CLDN18.2) is a surface membrane protein that is crucial for maintaining tight junctions in gastric mucosal cells and is highly…”
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Preclinical Evaluation of AZD6422, an Armored Chimeric Antigen Receptor T Cell Targeting CLDN18.2 in Gastric, Pancreatic, and Esophageal Cancer by Barrett, Allison M, Britton, Zachary T, Carrasco, Rosa A, Breen, Shannon, Broggi, Maria A S, Hatke, Amy, Clark, Benjamin, Yang, Chunning, Phipps, Sandrina, Ortiz, Lorenzo, Janocha, Brianna, Zanvit, Peter, Giraldo, Nicolas A, Martin, Philip L, Lapointe, Jean-Martin, Harder, Nathalie, Cornish, Georgina H, Attili, Bala N N R, Mazor, Yariv, Damschroder, Melissa, Cobbold, Mark, Moody, Gordon, Bosco, Emily E

“…CLDN18.2 is a surface membrane protein crucial for maintaining tight junctions in gastric mucosal cells and is highly expressed in gastric, esophageal, and…”
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Expression and Purification of G Protein-Coupled Receptor (GPCR) Transmembrane Peptides by Britton, Zachary T., Hanle, Elizabeth I., Robinson, Anne S.

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High-level expression in Saccharomyces cerevisiae enables isolation and spectroscopic characterization of functional human adenosine A 2a receptor by O’Malley, Michelle A., Lazarova, Tzvetana, Britton, Zachary T., Robinson, Anne S.

“…The G-protein coupled receptors (GPCRs) are a class of membrane proteins that trigger cellular responses to external stimuli, and are believed to be targets…”
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Healing and Normal Fibroblasts Exhibit Differential Proliferation, Collagen Production, [alpha]-SMA Expression, and Contraction by Agarwal, Charu, Britton, Zachary T, Alaseirlis, Dimosthenis A, Li, Yunxia, Wang, James H-c

“…This study determines the differences in proliferation, collagen production, α-smooth muscle actin (α-SMA) expression, and contraction between healing and…”
Get full text