Search Results - "Britton, Robert A"

Role of the Intestinal Microbiota in Resistance to Colonization by Clostridium difficile by Britton, Robert A, Young, Vincent B

“…Antibiotic-associated infection with the bacterial pathogen Clostridium difficile is a major cause of morbidity and increased health care costs. C difficile…”
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Mechanisms Underlying Microbial-Mediated Changes in Social Behavior in Mouse Models of Autism Spectrum Disorder by Sgritta, Martina, Dooling, Sean W., Buffington, Shelly A., Momin, Eric N., Francis, Michael B., Britton, Robert A., Costa-Mattioli, Mauro

“…Currently, there are no medications that effectively treat the core symptoms of Autism Spectrum Disorder (ASD). We recently found that the bacterial species…”
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Host-microbial symbiosis in the vertebrate gastrointestinal tract and the Lactobacillus reuteri paradigm by Walter, Jens, Britton, Robert A, Roos, Stefan

“…Vertebrates engage in symbiotic associations with vast and complex microbial communities that colonize their gastrointestinal tracts. Recent advances have…”
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Interaction between the intestinal microbiota and host in Clostridium difficile colonization resistance by Britton, Robert A, Young, Vincent B

“…Clostridium difficile infection (CDI) has become one of the most prevalent and costly nosocomial infections. In spite of the importance of CDI, our knowledge…”
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Histamine derived from probiotic Lactobacillus reuteri suppresses TNF via modulation of PKA and ERK signaling by Thomas, Carissa M, Hong, Teresa, van Pijkeren, Jan Peter, Hemarajata, Peera, Trinh, Dan V, Hu, Weidong, Britton, Robert A, Kalkum, Markus, Versalovic, James

“…Beneficial microbes and probiotic species, such as Lactobacillus reuteri, produce biologically active compounds that can modulate host mucosal immunity…”
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Probiotic Lactobacillus reuteri Prevents Postantibiotic Bone Loss by Reducing Intestinal Dysbiosis and Preventing Barrier Disruption by Schepper, Jonathan D, Collins, Fraser L., Rios‐Arce, Naiomy Deliz, Raehtz, Sandi, Schaefer, Laura, Gardinier, Joseph D, Britton, Robert A., Parameswaran, Narayanan, McCabe, Laura R

“…ABSTRACT Antibiotic treatment, commonly prescribed for bacterial infections, depletes and subsequently causes long‐term alterations in intestinal microbiota…”
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High efficiency recombineering in lactic acid bacteria by van Pijkeren, Jan-Peter, Britton, Robert A

“…The ability to efficiently generate targeted point mutations in the chromosome without the need for antibiotics, or other means of selection, is a powerful…”
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RbgA ensures the correct timing in the maturation of the 50S subunits functional sites by Seffouh, Amal, Trahan, Chirstian, Wasi, Tanzila, Jain, Nikhil, Basu, Kaustuv, Britton, Robert A, Oeffinger, Marlene, Ortega, Joaquin

“…RbgA is an essential protein for the assembly of the 50S subunit in Bacillus subtilis. Depletion of RbgA leads to the accumulation of the 45S intermediate. A…”
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Engineering bacterial thiosulfate and tetrathionate sensors for detecting gut inflammation by Daeffler, Kristina N‐M, Galley, Jeffrey D, Sheth, Ravi U, Ortiz‐Velez, Laura C, Bibb, Christopher O, Shroyer, Noah F, Britton, Robert A, Tabor, Jeffrey J

“…There is a groundswell of interest in using genetically engineered sensor bacteria to study gut microbiota pathways, and diagnose or treat associated diseases…”
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Role of GTPases in Bacterial Ribosome Assembly by BRITTON, Robert A

“…The assembly of the ribosome, a complex molecular machine composed of RNA and protein, is a poorly understood process. Recent work has demonstrated that…”
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Complete list of canonical post-transcriptional modifications in the Bacillus subtilis ribosome and their link to RbgA driven large subunit assembly by Popova, Anna M, Jain, Nikhil, Dong, Xiyu, Abdollah-Nia, Farshad, Britton, Robert A, Williamson, James R

“…Abstract Ribosomal RNA modifications in prokaryotes have been sporadically studied, but there is a lack of a comprehensive picture of modification sites across…”
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Loss of Bone and Wnt10b Expression in Male Type 1 Diabetic Mice Is Blocked by the Probiotic Lactobacillus reuteri by Zhang, Jing, Motyl, Katherine J, Irwin, Regina, MacDougald, Ormond A, Britton, Robert A, McCabe, Laura R

“…Type 1 diabetes (T1D)–induced osteoporosis is characterized by a predominant suppression of osteoblast number and activity, as well as increased bone marrow…”
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Lactobacillus reuteri 6475 Increases Bone Density in Intact Females Only under an Inflammatory Setting by Collins, Fraser L, Irwin, Regina, Bierhalter, Hayley, Schepper, Jonathan, Britton, Robert A, Parameswaran, Narayanan, McCabe, Laura R

“…We previously demonstrated that short-term oral administration of the probiotic Lactobacillus reuteri 6475 enhanced bone density in male but not female mice…”
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Gut-derived butyrate suppresses ocular surface inflammation by Schaefer, Laura, Hernandez, Humberto, Coats, Rosalind A., Yu, Zhiyuan, Pflugfelder, Stephen C., Britton, Robert A., de Paiva, Cintia S.

“…Dry eye is a common ocular inflammatory disorder characterized by tear film instability and reduced tear production. There is increasing evidence that…”
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Rotavirus induces intercellular calcium waves through ADP signaling by Chang-Graham, Alexandra L, Perry, Jacob L, Engevik, Melinda A, Engevik, Kristen A, Scribano, Francesca J, Gebert, J Thomas, Danhof, Heather A, Nelson, Joel C, Kellen, Joseph S, Strtak, Alicia C, Sastri, Narayan P, Estes, Mary K, Britton, Robert A, Versalovic, James, Hyser, Joseph M

“…Rotavirus causes severe diarrheal disease in children by broadly dysregulating intestinal homeostasis. However, the underlying mechanism(s) of…”
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Sjögren-Like Lacrimal Keratoconjunctivitis in Germ-Free Mice by Wang, Changjun, Zaheer, Mahira, Bian, Fang, Quach, Darin, Swennes, Alton G, Britton, Robert A, Pflugfelder, Stephen C, de Paiva, Cintia S

“…Commensal bacteria play an important role in the formation of the immune system but their role in the maintenance of immune homeostasis at the ocular surface…”
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Targeted sampling of natural product space to identify bioactive natural product-like polyketide macrolides by Wilson, Darryl M., Driedger, Daniel J., Liu, Dennis Y., Keerthisinghe, Sandra, Hermann, Adrian, Bieniossek, Christoph, Linington, Roger G., Britton, Robert A.

“…Polyketide or polyketide-like macrolides (pMLs) continue to serve as a source of inspiration for drug discovery. However, their inherent structural and…”
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The gut-eye-lacrimal gland-microbiome axis in Sjögren Syndrome by Trujillo-Vargas, Claudia M., Schaefer, Laura, Alam, Jehan, Pflugfelder, Stephen C., Britton, Robert A., de Paiva, Cintia S.

“…The bacterial communities that collectively inhabit our body are called the microbiome. Virtually all body surface harbors bacteria. Recent advances in…”
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Role of Lactobacillus reuteri cell and mucus-binding protein A (CmbA) in adhesion to intestinal epithelial cells and mucus in vitro by Jensen, Hanne, Roos, Stefan, Jonsson, Hans, Rud, Ida, Grimmer, Stine, van Pijkeren, Jan-Peter, Britton, Robert A, Axelsson, Lars

“…Lactobacillus reuteri, a symbiotic inhabitant of the gastrointestinal tract in humans and animals, is marketed as a probiotic. The ability to adhere to…”
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Differentially Expressed Gene Pathways in the Conjunctiva of Sjögren Syndrome Keratoconjunctivitis Sicca by de Paiva, Cintia S, Trujillo-Vargas, Claudia M, Schaefer, Laura, Yu, Zhiyuan, Britton, Robert A, Pflugfelder, Stephen C

“…Sjögren syndrome (SS) is an autoimmune condition that targets the salivary and lacrimal glands, with cardinal clinical signs of dry eye (keratoconjunctivitis…”
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