Search Results - "Britton, Brooke M"
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Cascading MutS and MutL sliding clamps control DNA diffusion to activate mismatch repair
Published in Nature (London) (24-11-2016)“…MutS and MutL—the highly conserved core proteins responsible for the repair of mismatched DNA—form sequential stable sliding clamps that together modulate…”
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Conformational changes in the essential E. coli septal cell wall synthesis complex suggest an activation mechanism
Published in Nature communications (31-07-2023)“…The bacterial divisome is a macromolecular machine composed of more than 30 proteins that controls cell wall constriction during division. Here, we present a…”
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MutL sliding clamps coordinate exonuclease-independent Escherichia coli mismatch repair
Published in Nature communications (22-11-2019)“…A shared paradigm of mismatch repair (MMR) across biology depicts extensive exonuclease-driven strand-specific excision that begins at a distant…”
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Exploiting the distinctive properties of the bacterial and human MutS homolog sliding clamps on mismatched DNA
Published in The Journal of biological chemistry (01-11-2022)“…MutS homologs (MSHs) are highly conserved core components of DNA mismatch repair. Mismatch recognition provokes ATP-binding by MSH proteins that drives a…”
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MutS homolog sliding clamps shield the DNA from binding proteins
Published in The Journal of biological chemistry (14-09-2018)“…Sliding clamps on DNA consist of evolutionarily conserved enzymes that coordinate DNA replication, repair, and the cellular DNA damage response. MutS homolog…”
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An Efficient Site-Specific Method for Irreversible Covalent Labeling of Proteins with a Fluorophore
Published in Scientific reports (19-11-2015)“…Fluorophore labeling of proteins while preserving native functions is essential for bulk Förster resonance energy transfer (FRET) interaction and single…”
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Cascading MutS and MutL sliding clamps control DNA diffusion to activate mismatch repair
Published in Nature (London) (24-11-2016)“…Mismatched nucleotides arise from polymerase misincorporation errors, recombination between heteroallelic parents and chemical or physical DNA damage. Highly…”
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Muts Homolog Sliding Clamps Shield the DNA from Binding Proteins
Published in Biophysical journal (01-02-2019)Get full text
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