Search Results - "Brittenham, G."

Hepatic Iron Concentration and Total Body Iron Stores in Thalassemia Major by Angelucci, Emanuele, Brittenham, Gary M, McLaren, Christine E, Ripalti, Marta, Baronciani, Donatella, Giardini, Claudio, Galimberti, Maria, Polchi, Paola, Lucarelli, Guido

“…Quantitative studies of iron balance in patients with thalassemia major have been limited by the lack of a method for determining the total amount of stored…”
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Delayed hemolytic transfusion reaction in the French hemovigilance system by Rieux, C., Brittenham, G., Bachir, D., De Meyer, E., Boudjedir, K.

“…In France, reporting of adverse events related, or likely to be related, to transfusion is mandatory. Since its creation in 1993, the French hemovigilance…”
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Iron-chelating therapy and the treatment of thalassemia by OLIVIERI, N. F, BRITTENHAM, G. M

“…Iron-chelating therapy with deferoxamine in patients with thalassemia major has dramatically altered the prognosis of this previously fatal disease. The…”
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Long-Term Safety and Effectiveness of Iron-Chelation Therapy with Deferiprone for Thalassemia Major by Olivieri, Nancy F, Brittenham, Gary M, McLaren, Christine E, Templeton, Douglas M, Cameron, Ross G, McClelland, Robert A, Burt, Alastair D, Fleming, Kenneth A

“…Transfusions and iron-chelation therapy have dramatically improved the lives of patients with thalassemia major. 1 Transfusions can prevent death and promote…”
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Efficacy of Deferoxamine in Preventing Complications of Iron Overload in Patients with Thalassemia Major by Brittenham, Gary M, Griffith, Patricia M, Nienhuis, Arthur W, McLaren, Christine E, Young, Neal S, Tucker, Eben E, Allen, Christopher J, Farrell, David E, Harris, John W

“…An adequate transfusion program for patients with thalassemia major can prevent death from anemia in infancy and permit normal growth and development during…”
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Iron-Chelation Therapy with Oral Deferiprone in Patients with Thalassemia Major by Olivieri, Nancy F, Brittenham, Gary M, Matsui, Doreen, Berkovitch, Matitiahu, Blendis, Laurence M, Cameron, Ross G, McClelland, Robert A, Liu, Peter P, Templeton, Douglas M, Koren, Gideon

“…In patients with thalassemia major, a regular program of transfusion sustains growth and development during childhood, but without concomitant chelation…”
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Iron balance in the red blood cell donor by Brittenham, G M

“…Phlebotomy of a unit of blood produces a loss of 200 to 250 mg of iron in haemoglobin. Because of physiological differences in iron balance between women of…”
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Genetic Disorders Affecting Proteins of Iron Metabolism: Clinical Implications by Sheth, Sujit, Brittenham, Gary M

“…Remarkable progress is being made in understanding the molecular basis of disorders of human iron metabolism. Recent work has uncovered unanticipated…”
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Decreased sodium and increased transient outward potassium currents in iron-loaded cardiac myocytes: Implications for the arrhythmogenesis of human siderotic heart disease by KURYSHEV, Y. A, BRITTENHAM, G. M, FUJIOKA, H, KANNAN, P, SHIEH, C.-C, COHEN, S. A, BROWN, A. M

“…Patients with chronic iron overload may develop a cardiomyopathy manifested by ventricular arrhythmias and heart failure. We hypothesized that iron-loaded…”
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Magnetic Measurement of Liver Iron Stores: Engineering Aspects of a New Scanning Susceptometer Based on High-Temperature Superconductivity by Farrell, D.E., Allen, C.J., Whilden, M.W., Tripp, J.H., Usoskin, A., Sheth, S., Brittenham, G.M.

“…We describe a new approach to the magnetic measurement of liver iron stores, using an instrument that incorporates a combination of permanent magnets and…”
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Influence of Hemoglobin E Trait on the Severity of Falciparum Malaria by Hutagalung, Robert, Wilairatana, Polrat, Looareesuwan, Sornchai, Brittenham, Gary M., Aikawa, Masamichi, Gordeuk, Victor R.

“…To determine if hemoglobin E trait influences the course of acute malaria, adults hospitalized for the treatment of symptomatic infection with Plasmodium…”
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A New Instrument Designed to Measure the Magnetic Susceptibility of Human Liver Tissue In Vivo by Farrell, D.E., Allen, C.J., Whilden, M.W., Kidane, T.K., Baig, T.N., Tripp, J.H., Brown, R.W., Sheth, S., Brittenham, G.M.

“…All existing superconducting instrumentation for measuring the concentration of iron stored in the human liver requires liquid helium for its operation. We…”
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Experimental liver cirrhosis induced by alcohol and iron by Tsukamoto, H, Horne, W, Kamimura, S, Niemelä, O, Parkkila, S, Ylä-Herttuala, S, Brittenham, G M

“…To determine if alcoholic liver fibrogenesis is exacerbated by dietary iron supplementation, carbonyl iron (0.25% wt/vol) was intragastrically infused with or…”
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HBED : A potential alternative to deferoxamine for iron-chelating therapy by BERGERON, R. J, WIEGAND, J, BRITTENHAM, G. M

“…To examine the potential clinical usefulness of the hexadentate phenolic aminocarboxylate iron chelator N, N-bis(2-hydroxybenzyl)ethylenediamine-N,N-diacetic…”
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Treatment of thalassaemia major with phenylbutyrate and hydroxyurea by Olivieri, N F, Rees, D C, Ginder, G D, Thein, S L, Brittenham, G M, Waye, J S, Weatherall, D J

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Deferiprone versus desferrioxamine in thalassaemia, and T2 validation and utility by Brittenham, GM, Nathan, DG, Olivieri, NF, Pippard, MJ, Weatherall, DJ

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Effects of C-4 Stereochemistry and C-4‘ Hydroxylation on the Iron Clearing Efficiency and Toxicity of Desferrithiocin Analogues by Bergeron, Raymond J, Wiegand, Jan, McManis, James S, McCosar, Bruce H, Weimar, William R, Brittenham, Gary M, Smith, Richard E

“…Additional structure−activity studies of desferrithiocin analogues are carried out. The effects of stereochemistry at C-4 on the ligands' iron clearing…”
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Development of Iron-Chelating Agents for Clinical Use by Brittenham, Gary M.

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New advances in iron metabolism, iron deficiency, and iron overload by Brittenham, G M

“…Rapid advances were made in understanding the molecular and cellular bases of iron metabolism and its disorders. Molecular mechanisms for the cellular uptake,…”
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Iron chelators and iron toxicity by Brittenham, Gary M.

“…Iron chelation may offer new approaches to the treatment and prevention of alcoholic liver disease. With chronic excess, either iron or alcohol alone may…”
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