Search Results - "Brittain, William D. G."

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  1. 1

    Carboxylic Acid Deoxyfluorination and One-Pot Amide Bond Formation Using Pentafluoropyridine (PFP) by Brittain, William D. G, Cobb, Steven L

    Published in Organic letters (06-08-2021)
    “…This work describes the application of pentafluoropyridine (PFP), a cheap commercially available reagent, in the deoxyfluorination of carboxylic acids to acyl…”
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  2. 2
  3. 3

    One-pot ester and thioester formation mediated by pentafluoropyridine (PFP) by Beardmore, Liam N D, Cobb, Steven L, Brittain, William D G

    Published in Organic & biomolecular chemistry (26-10-2022)
    “…Acyl fluorides are valuable synthetic intermediates, but in some cases they can be challenging to handle and difficult to isolate given their susceptibility to…”
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  4. 4

    Aminoacyl chain translocation catalysed by a type II thioesterase domain in an unusual non-ribosomal peptide synthetase by Wang, Shan, Brittain, William D. G., Zhang, Qian, Lu, Zhou, Tong, Ming Him, Wu, Kewen, Kyeremeh, Kwaku, Jenner, Matthew, Yu, Yi, Cobb, Steven L., Deng, Hai

    Published in Nature communications (10-01-2022)
    “…Non-Ribosomal Peptide Synthetases (NRPSs) assemble a diverse range of natural products with important applications in both medicine and agriculture. They…”
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  5. 5

    Synthesis of complex unnatural fluorine-containing amino acids by Brittain, William D.G., Lloyd, Carissa M., Cobb, Steven L.

    Published in Journal of fluorine chemistry (01-11-2020)
    “…[Display omitted] The area of fluorinated amino acid synthesis has seen rapid growth over the past decade. As reports of singly fluorinated natural amino acid…”
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  6. 6

    Kinetic resolution of alkyne-substituted quaternary oxindoles via copper catalysed azide-alkyne cycloadditions by Brittain, William D G, Buckley, Benjamin R, Fossey, John S

    “…The synthesis and kinetic resolution of quaternary oxindoles through copper catalysed azide-alkyne cycloadditions is presented. Selectivity factors (s) up to…”
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  7. 7

    Coetaneous catalytic kinetic resolution of alkynes and azides through asymmetric triazole formation by Brittain, William D. G., Dalling, Andrew G., Sun, Zhenquan, Duff, Cécile S. Le, Male, Louise, Buckley, Benjamin R., Fossey, John S.

    Published in Scientific reports (21-10-2019)
    “…A non-enzymatic simultaneous (coined coetaneous) kinetic resolution of a racemic alkyne and racemic azide, utilising an asymmetric CuAAC reaction is reported…”
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  8. 8

    Synthesis of pentafluorosulfanyl (SF5) containing aromatic amino acids by Grigolato, Lucas, Brittain, William D.G., Hudson, Alex S., Czyzewska, Maria M., Cobb, Steven L.

    Published in Journal of fluorine chemistry (01-08-2018)
    “…Herein, a series of aromatic pentafluorosulfanyl (SF5) containing amino acids are reported. A Negishi cross-coupling strategy utilising a catalyst system of…”
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  9. 9

    Perfluoroaryl and Perfluoroheteroaryl Reagents as Emerging New Tools for Peptide Synthesis, Modification and Bioconjugation by Brittain, William D. G., Coxon, Christopher R.

    Published in Chemistry : a European journal (01-02-2022)
    “…Peptides and proteins are becoming increasingly valuable as medicines, diagnostic agents and as tools for biomedical sciences. Much of this has been…”
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  10. 10

    Frontispiece: Perfluoroaryl and Perfluoroheteroaryl Reagents as Emerging New Tools for Peptide Synthesis, Modification and Bioconjugation by Brittain, William D. G., Coxon, Christopher R.

    Published in Chemistry : a European journal (01-02-2022)
    “…Perfluorinated aromatics and heteroaromatics are versatile reagents for the modification of amino acids, peptides and proteins. This is principally because…”
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  11. 11

    Asymmetric Copper-Catalyzed Azide–Alkyne Cycloadditions by Brittain, William D. G, Buckley, Benjamin R, Fossey, John S

    Published in ACS catalysis (03-06-2016)
    “…Since its discovery independently by Sharpless and Meldal in 2002, the copper-catalyzed azide–alkyne cycloaddition (CuAAC) has become a ubiquitous molecular…”
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  12. 12

    Protecting Group-Controlled Remote Regioselective Electrophilic Aromatic Halogenation Reactions by Brittain, William D G, Cobb, Steven L

    Published in Journal of organic chemistry (05-06-2020)
    “…Being able to utilize a protecting group to influence remote regiocontrol offers a simple alternative approach to direct late-stage functionalization of…”
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  13. 13

    HFO‐1234yf as a CF3 Building Block: Synthesis of Trifluoromethyl Quinoline and Chromene Derivatives from Trifluoromethyl‐ynones by Marsh, Thomas G. F., Santambrogio, Alessia, Murray, Ben J., Boulton, Lee T., Aguilar, Juan A., Yufit, Dmitry S., Sandford, Graham, Brittain, William D. G.

    Published in European journal of organic chemistry (14-03-2023)
    “…Trifluoromethyl ynones derived from the refrigerant gas HFO‐1234yf (2,3,3,3‐tetrafluoropropene) react with nucleophiles via a Michael‐type addition process and…”
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  14. 14

    Predicting the increase in electron affinity of phenoxy upon fluorination by Clarke, Connor J., Gibbard, Jemma A., Brittain, William D.G., Verlet, Jan R.R.

    Published in Journal of fluorine chemistry (01-07-2024)
    “…•Anion photoelectron spectroscopy provides a direct measure of fluorinated isomers of phenolate.•The electron affinity of mono-fluorinated phenoxy radicals is…”
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  15. 15

    HFO‐1234yf as a CF 3 Building Block: Synthesis of Trifluoromethyl Quinoline and Chromene Derivatives from Trifluoromethyl‐ynones by Marsh, Thomas G. F., Santambrogio, Alessia, Murray, Ben J., Boulton, Lee T., Aguilar, Juan A., Yufit, Dmitry S., Sandford, Graham, Brittain, William D. G.

    Published in European journal of organic chemistry (14-03-2023)
    “…Abstract Trifluoromethyl ynones derived from the refrigerant gas HFO‐1234yf (2,3,3,3‐tetrafluoropropene) react with nucleophiles via a Michael‐type addition…”
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    Journal Article