Search Results - "Brittain, William D. G."
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Carboxylic Acid Deoxyfluorination and One-Pot Amide Bond Formation Using Pentafluoropyridine (PFP)
Published in Organic letters (06-08-2021)“…This work describes the application of pentafluoropyridine (PFP), a cheap commercially available reagent, in the deoxyfluorination of carboxylic acids to acyl…”
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2
Rapid Determination of Enantiomeric Excess via NMR Spectroscopy: A Research-Informed Experiment
Published in Journal of chemical education (10-01-2017)“…An undergraduate chemistry experiment that draws from primary research is described. The experiment exploits chiral supramolecular assemblies for the…”
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3
One-pot ester and thioester formation mediated by pentafluoropyridine (PFP)
Published in Organic & biomolecular chemistry (26-10-2022)“…Acyl fluorides are valuable synthetic intermediates, but in some cases they can be challenging to handle and difficult to isolate given their susceptibility to…”
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4
Aminoacyl chain translocation catalysed by a type II thioesterase domain in an unusual non-ribosomal peptide synthetase
Published in Nature communications (10-01-2022)“…Non-Ribosomal Peptide Synthetases (NRPSs) assemble a diverse range of natural products with important applications in both medicine and agriculture. They…”
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5
Synthesis of complex unnatural fluorine-containing amino acids
Published in Journal of fluorine chemistry (01-11-2020)“…[Display omitted] The area of fluorinated amino acid synthesis has seen rapid growth over the past decade. As reports of singly fluorinated natural amino acid…”
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Kinetic resolution of alkyne-substituted quaternary oxindoles via copper catalysed azide-alkyne cycloadditions
Published in Chemical communications (Cambridge, England) (18-12-2015)“…The synthesis and kinetic resolution of quaternary oxindoles through copper catalysed azide-alkyne cycloadditions is presented. Selectivity factors (s) up to…”
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7
Coetaneous catalytic kinetic resolution of alkynes and azides through asymmetric triazole formation
Published in Scientific reports (21-10-2019)“…A non-enzymatic simultaneous (coined coetaneous) kinetic resolution of a racemic alkyne and racemic azide, utilising an asymmetric CuAAC reaction is reported…”
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Synthesis of pentafluorosulfanyl (SF5) containing aromatic amino acids
Published in Journal of fluorine chemistry (01-08-2018)“…Herein, a series of aromatic pentafluorosulfanyl (SF5) containing amino acids are reported. A Negishi cross-coupling strategy utilising a catalyst system of…”
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Perfluoroaryl and Perfluoroheteroaryl Reagents as Emerging New Tools for Peptide Synthesis, Modification and Bioconjugation
Published in Chemistry : a European journal (01-02-2022)“…Peptides and proteins are becoming increasingly valuable as medicines, diagnostic agents and as tools for biomedical sciences. Much of this has been…”
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Frontispiece: Perfluoroaryl and Perfluoroheteroaryl Reagents as Emerging New Tools for Peptide Synthesis, Modification and Bioconjugation
Published in Chemistry : a European journal (01-02-2022)“…Perfluorinated aromatics and heteroaromatics are versatile reagents for the modification of amino acids, peptides and proteins. This is principally because…”
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11
Asymmetric Copper-Catalyzed Azide–Alkyne Cycloadditions
Published in ACS catalysis (03-06-2016)“…Since its discovery independently by Sharpless and Meldal in 2002, the copper-catalyzed azide–alkyne cycloaddition (CuAAC) has become a ubiquitous molecular…”
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12
Protecting Group-Controlled Remote Regioselective Electrophilic Aromatic Halogenation Reactions
Published in Journal of organic chemistry (05-06-2020)“…Being able to utilize a protecting group to influence remote regiocontrol offers a simple alternative approach to direct late-stage functionalization of…”
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13
HFO‐1234yf as a CF3 Building Block: Synthesis of Trifluoromethyl Quinoline and Chromene Derivatives from Trifluoromethyl‐ynones
Published in European journal of organic chemistry (14-03-2023)“…Trifluoromethyl ynones derived from the refrigerant gas HFO‐1234yf (2,3,3,3‐tetrafluoropropene) react with nucleophiles via a Michael‐type addition process and…”
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14
Predicting the increase in electron affinity of phenoxy upon fluorination
Published in Journal of fluorine chemistry (01-07-2024)“…•Anion photoelectron spectroscopy provides a direct measure of fluorinated isomers of phenolate.•The electron affinity of mono-fluorinated phenoxy radicals is…”
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HFO‐1234yf as a CF 3 Building Block: Synthesis of Trifluoromethyl Quinoline and Chromene Derivatives from Trifluoromethyl‐ynones
Published in European journal of organic chemistry (14-03-2023)“…Abstract Trifluoromethyl ynones derived from the refrigerant gas HFO‐1234yf (2,3,3,3‐tetrafluoropropene) react with nucleophiles via a Michael‐type addition…”
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