Search Results - "Brittain, William D G"

Carboxylic Acid Deoxyfluorination and One-Pot Amide Bond Formation Using Pentafluoropyridine (PFP) by Brittain, William D. G, Cobb, Steven L

“…This work describes the application of pentafluoropyridine (PFP), a cheap commercially available reagent, in the deoxyfluorination of carboxylic acids to acyl…”
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Rapid Determination of Enantiomeric Excess via NMR Spectroscopy: A Research-Informed Experiment by Fossey, John S, Anslyn, Eric V, Brittain, William D. G, Bull, Steven D, Chapin, Brette M, Le Duff, Cécile S, James, Tony D, Lees, Glenn, Lim, Stephanie, Lloyd, Jennifer A. C, Manville, Charles V, Payne, Daniel T, Roper, Kimberley A

“…An undergraduate chemistry experiment that draws from primary research is described. The experiment exploits chiral supramolecular assemblies for the…”
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One-pot ester and thioester formation mediated by pentafluoropyridine (PFP) by Beardmore, Liam N D, Cobb, Steven L, Brittain, William D G

“…Acyl fluorides are valuable synthetic intermediates, but in some cases they can be challenging to handle and difficult to isolate given their susceptibility to…”
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Aminoacyl chain translocation catalysed by a type II thioesterase domain in an unusual non-ribosomal peptide synthetase by Wang, Shan, Brittain, William D. G., Zhang, Qian, Lu, Zhou, Tong, Ming Him, Wu, Kewen, Kyeremeh, Kwaku, Jenner, Matthew, Yu, Yi, Cobb, Steven L., Deng, Hai

“…Non-Ribosomal Peptide Synthetases (NRPSs) assemble a diverse range of natural products with important applications in both medicine and agriculture. They…”
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Synthesis of complex unnatural fluorine-containing amino acids by Brittain, William D.G., Lloyd, Carissa M., Cobb, Steven L.

“…[Display omitted] The area of fluorinated amino acid synthesis has seen rapid growth over the past decade. As reports of singly fluorinated natural amino acid…”
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Kinetic resolution of alkyne-substituted quaternary oxindoles via copper catalysed azide-alkyne cycloadditions by Brittain, William D G, Buckley, Benjamin R, Fossey, John S

“…The synthesis and kinetic resolution of quaternary oxindoles through copper catalysed azide-alkyne cycloadditions is presented. Selectivity factors (s) up to…”
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Coetaneous catalytic kinetic resolution of alkynes and azides through asymmetric triazole formation by Brittain, William D. G., Dalling, Andrew G., Sun, Zhenquan, Duff, Cécile S. Le, Male, Louise, Buckley, Benjamin R., Fossey, John S.

“…A non-enzymatic simultaneous (coined coetaneous) kinetic resolution of a racemic alkyne and racemic azide, utilising an asymmetric CuAAC reaction is reported…”
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Synthesis of pentafluorosulfanyl (SF5) containing aromatic amino acids by Grigolato, Lucas, Brittain, William D.G., Hudson, Alex S., Czyzewska, Maria M., Cobb, Steven L.

“…Herein, a series of aromatic pentafluorosulfanyl (SF5) containing amino acids are reported. A Negishi cross-coupling strategy utilising a catalyst system of…”
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Perfluoroaryl and Perfluoroheteroaryl Reagents as Emerging New Tools for Peptide Synthesis, Modification and Bioconjugation by Brittain, William D. G., Coxon, Christopher R.

“…Peptides and proteins are becoming increasingly valuable as medicines, diagnostic agents and as tools for biomedical sciences. Much of this has been…”
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Frontispiece: Perfluoroaryl and Perfluoroheteroaryl Reagents as Emerging New Tools for Peptide Synthesis, Modification and Bioconjugation by Brittain, William D. G., Coxon, Christopher R.

“…Perfluorinated aromatics and heteroaromatics are versatile reagents for the modification of amino acids, peptides and proteins. This is principally because…”
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Asymmetric Copper-Catalyzed Azide–Alkyne Cycloadditions by Brittain, William D. G, Buckley, Benjamin R, Fossey, John S

“…Since its discovery independently by Sharpless and Meldal in 2002, the copper-catalyzed azide–alkyne cycloaddition (CuAAC) has become a ubiquitous molecular…”
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Protecting Group-Controlled Remote Regioselective Electrophilic Aromatic Halogenation Reactions by Brittain, William D G, Cobb, Steven L

“…Being able to utilize a protecting group to influence remote regiocontrol offers a simple alternative approach to direct late-stage functionalization of…”
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HFO‐1234yf as a CF3 Building Block: Synthesis of Trifluoromethyl Quinoline and Chromene Derivatives from Trifluoromethyl‐ynones by Marsh, Thomas G. F., Santambrogio, Alessia, Murray, Ben J., Boulton, Lee T., Aguilar, Juan A., Yufit, Dmitry S., Sandford, Graham, Brittain, William D. G.

“…Trifluoromethyl ynones derived from the refrigerant gas HFO‐1234yf (2,3,3,3‐tetrafluoropropene) react with nucleophiles via a Michael‐type addition process and…”
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Predicting the increase in electron affinity of phenoxy upon fluorination by Clarke, Connor J., Gibbard, Jemma A., Brittain, William D.G., Verlet, Jan R.R.

“…•Anion photoelectron spectroscopy provides a direct measure of fluorinated isomers of phenolate.•The electron affinity of mono-fluorinated phenoxy radicals is…”
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HFO‐1234yf as a CF 3 Building Block: Synthesis of Trifluoromethyl Quinoline and Chromene Derivatives from Trifluoromethyl‐ynones by Marsh, Thomas G. F., Santambrogio, Alessia, Murray, Ben J., Boulton, Lee T., Aguilar, Juan A., Yufit, Dmitry S., Sandford, Graham, Brittain, William D. G.

“…Abstract Trifluoromethyl ynones derived from the refrigerant gas HFO‐1234yf (2,3,3,3‐tetrafluoropropene) react with nucleophiles via a Michael‐type addition…”
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