Search Results - "Britschgi, Markus"

Cryo-EM structure of alpha-synuclein fibrils by Guerrero-Ferreira, Ricardo, Taylor, Nicholas Mi, Mona, Daniel, Ringler, Philippe, Lauer, Matthias E, Riek, Roland, Britschgi, Markus, Stahlberg, Henning

“…Parkinson's disease is a progressive neuropathological disorder that belongs to the class of synucleinopathies, in which the protein alpha-synuclein is found…”
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Lewy pathology in Parkinson’s disease consists of crowded organelles and lipid membranes by Shahmoradian, Sarah H., Lewis, Amanda J., Genoud, Christel, Hench, Jürgen, Moors, Tim E., Navarro, Paula P., Castaño-Díez, Daniel, Schweighauser, Gabriel, Graff-Meyer, Alexandra, Goldie, Kenneth N., Sütterlin, Rosmarie, Huisman, Evelien, Ingrassia, Angela, Gier, Yvonne de, Rozemuller, Annemieke J. M., Wang, Jing, Paepe, Anne De, Erny, Johannes, Staempfli, Andreas, Hoernschemeyer, Joerg, Großerüschkamp, Frederik, Niedieker, Daniel, El-Mashtoly, Samir F., Quadri, Marialuisa, Van IJcken, Wilfred F. J., Bonifati, Vincenzo, Gerwert, Klaus, Bohrmann, Bernd, Frank, Stephan, Britschgi, Markus, Stahlberg, Henning, Van de Berg, Wilma D. J., Lauer, Matthias E.

“…Parkinson’s disease, the most common age-related movement disorder, is a progressive neurodegenerative disease with unclear etiology. Key neuropathological…”
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Maternal immune activation and abnormal brain development across CNS disorders by Knuesel, Irene, Chicha, Laurie, Britschgi, Markus, Schobel, Scott A., Bodmer, Michael, Hellings, Jessica A., Toovey, Stephen, Prinssen, Eric P.

“…Key Points The developing brain is particularly sensitive to environmental signals that influence genetically determined developmental processes…”
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Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy by Guerrero-Ferreira, Ricardo, Taylor, Nicholas Mi, Arteni, Ana-Andreea, Kumari, Pratibha, Mona, Daniel, Ringler, Philippe, Britschgi, Markus, Lauer, Matthias E, Makky, Ali, Verasdonck, Joeri, Riek, Roland, Melki, Ronald, Meier, Beat H, Böckmann, Anja, Bousset, Luc, Stahlberg, Henning

“…Intracellular inclusions rich in alpha-synuclein are a hallmark of several neuropathological diseases including Parkinson's disease (PD). Previously, we…”
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Large-Scale Production of Human iPSC-Derived Macrophages for Drug Screening by Gutbier, Simon, Wanke, Florian, Dahm, Nadine, Rümmelin, Anna, Zimmermann, Silke, Christensen, Klaus, Köchl, Fabian, Rautanen, Anna, Hatje, Klas, Geering, Barbara, Zhang, Jitao David, Britschgi, Markus, Cowley, Sally A, Patsch, Christoph

“…Tissue-resident macrophages are key players in inflammatory processes, and their activation and functionality are crucial in health and disease. Numerous…”
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Colony-stimulating factor 1 receptor (CSF1R) signaling in injured neurons facilitates protection and survival by Luo, Jian, Elwood, Fiona, Britschgi, Markus, Villeda, Saul, Zhang, Hui, Ding, Zhaoqing, Zhu, Liyin, Alabsi, Haitham, Getachew, Ruth, Narasimhan, Ramya, Wabl, Rafael, Fainberg, Nina, James, Michelle L, Wong, Gordon, Relton, Jane, Gambhir, Sanjiv S, Pollard, Jeffrey W, Wyss-Coray, Tony

“…Colony-stimulating factor 1 (CSF1) and interleukin-34 (IL-34) are functional ligands of the CSF1 receptor (CSF1R) and thus are key regulators of the…”
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Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins by Wyss-Coray, Tony, Ray, Sandip, Britschgi, Markus, Herbert, Charles, Takeda-Uchimura, Yoshiko, Boxer, Adam, Blennow, Kaj, Friedman, Leah F, Galasko, Douglas R, Jutel, Marek, Karydas, Anna, Kaye, Jeffrey A, Leszek, Jerzy, Miller, Bruce L, Minthon, Lennart, Quinn, Joseph F, Rabinovici, Gil D, Robinson, William H, Sabbagh, Marwan N, So, Yuen T, Sparks, D Larry, Tabaton, Massimo, Tinklenberg, Jared, Yesavage, Jerome A, Tibshirani, Robert

“…A molecular test for Alzheimer's disease could lead to better treatment and therapies. We found 18 signaling proteins in blood plasma that can be used to…”
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Epigenetic inactivation of the autophagy–lysosomal system in appendix in Parkinson’s disease by Gordevicius, Juozas, Li, Peipei, Marshall, Lee L., Killinger, Bryan A., Lang, Sean, Ensink, Elizabeth, Kuhn, Nathan C., Cui, Wei, Maroof, Nazia, Lauria, Roberta, Rueb, Christina, Siebourg-Polster, Juliane, Maliver, Pierre, Lamp, Jared, Vega, Irving, Manfredsson, Fredric P., Britschgi, Markus, Labrie, Viviane

“…The gastrointestinal tract may be a site of origin for α-synuclein pathology in idiopathic Parkinson’s disease (PD). Disruption of the autophagy-lysosome…”
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Alzheimer's Risk Gene TREM2 Determines Functional Properties of New Type of Human iPSC-Derived Microglia by Reich, Marvin, Paris, Iñaki, Ebeling, Martin, Dahm, Nadine, Schweitzer, Christophe, Reinhardt, Dieter, Schmucki, Roland, Prasad, Megana, Köchl, Fabian, Leist, Marcel, Cowley, Sally A, Zhang, Jitao David, Patsch, Christoph, Gutbier, Simon, Britschgi, Markus

“…Microglia are key in the homeostatic well-being of the brain and microglial dysfunction has been implicated in neurodegenerative disorders such as Alzheimer's…”
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Generation of an hiPSC-Derived Co-Culture System to Assess the Effects of Neuroinflammation on Blood-Brain Barrier Integrity by Bull, Daniel, Schweitzer, Christophe, Bichsel, Colette, Britschgi, Markus, Gutbier, Simon

“…The blood-brain barrier (BBB) regulates the interaction between the highly vulnerable central nervous system (CNS) and the peripheral parts of the body…”
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Parkinson mice show functional and molecular changes in the gut long before motoric disease onset by Gries, Manuela, Christmann, Anne, Schulte, Steven, Weyland, Maximilian, Rommel, Stephanie, Martin, Monika, Baller, Marko, Röth, Ralph, Schmitteckert, Stefanie, Unger, Marcus, Liu, Yang, Sommer, Frederik, Mühlhaus, Timo, Schroda, Michael, Timmermans, Jean-Pierre, Pintelon, Isabel, Rappold, Gudrun A, Britschgi, Markus, Lashuel, Hilal, Menger, Michael D, Laschke, Matthias W, Niesler, Beate, Schäfer, Karl-Herbert

“…There is increasing evidence that Parkinson's disease (PD) might start in the gut, thus involving and compromising also the enteric nervous system (ENS). At…”
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Deficiency of terminal complement pathway inhibitor promotes neuronal tau pathology and degeneration in mice by Britschgi, Markus, Takeda-Uchimura, Yoshiko, Rockenstein, Edward, Johns, Hudson, Masliah, Eliezer, Wyss-Coray, Tony

“…The neuronal microtubule-associated protein tau becomes hyperphosphorylated and forms aggregates in tauopathies but the processes leading to this pathological…”
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Multi-platform quantitation of alpha-synuclein human brain proteoforms suggests disease-specific biochemical profiles of synucleinopathies by Moors, Tim E, Mona, Daniel, Luehe, Stefan, Duran-Pacheco, Gonzalo, Spycher, Liz, Mundigl, Olaf, Kaluza, Klaus, Huber, Sylwia, Hug, Melanie N, Kremer, Thomas, Ritter, Mirko, Dziadek, Sebastian, Dernick, Gregor, van de Berg, Wilma D J, Britschgi, Markus

“…Based on immunostainings and biochemical analyses, certain post-translationally modified alpha-synuclein (aSyn) variants, including C-terminally truncated…”
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Modeling of Pathological Traits in Alzheimer's Disease Based on Systemic Extracellular Signaling Proteome by Britschgi, Markus, Rufibach, Kaspar, Huang, Sarah L. Bauer, Clark, Christopher M., Kaye, Jeffrey A., Li, Ge, Peskind, Elaine R., Quinn, Joseph F., Galasko, Douglas R., Wyss-Coray, Tony

“…The study of chronic brain diseases including Alzheimer's disease in patients is typically limited to brain imaging or psychometric testing. Given the epidemic…”
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Specific immune modulation of experimental colitis drives enteric alpha-synuclein accumulation and triggers age-related Parkinson-like brain pathology by Grathwohl, Stefan, Quansah, Emmanuel, Maroof, Nazia, Steiner, Jennifer A, Spycher, Liz, Benmansour, Fethalla, Duran-Pacheco, Gonzalo, Siebourg-Polster, Juliane, Oroszlan-Szovik, Krisztina, Remy, Helga, Haenggi, Markus, Stawiski, Marc, Selhausen, Matthias, Mailver, Pierre, Wolfert, Andreas, Emrich, Thomas, Madaj, Zachary, Su, Arel, Escobar Galvis, Martha L, Mueller, Christoph, Herrmann, Annika, Brundin, Patrik, Britschgi, Markus

“…: In some people with Parkinson's disease (PD), α-synuclein (αSyn) accumulation may begin in the enteric nervous system (ENS) decades before development of…”
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Cross-reactivity patterns of T cells specific for iodinated contrast media by Lerch, Marianne, MD, Keller, Monika, PhD, Britschgi, Markus, PhD, Kanny, Gisele, MD, PhD, Tache, Valerie, Schmid, Daphne A., PhD, Beeler, Andreas, MSc, Gerber, Basil O., PhD, Luethi, Michael, Bircher, Andreas J., MD, Christiansen, Cathrine, MSc, Pichler, Werner J., MD

“…Background Approximately 3% of patients exposed to iodinated contrast media develop delayed hypersensitivity reactions. Objective We wanted to better…”
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Blood protein signature for the early diagnosis of Alzheimer disease by Britschgi, Markus, Wyss-Coray, Tony

“…Alzheimer disease (AD) has become one of the main health concerns for the elderly population in the United States. Current treatments target symptoms only, but…”
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Molecular aspects of drug recognition by specific T cells by Britschgi, Markus, von Greyerz, Salome, Burkhart, Christoph, Pichler, Werner J

“…Adverse reactions to drugs are a major problem in pharmacotherapy. About 1/6 of all side-effects are thought to be drug-induced immune-mediated reactions. It…”
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Cellular and molecular pathophysiology of cutaneous drug reactions by Pichler, Werner J, Yawalkar, Nikhil, Britschgi, Markus, Depta, Jan, Strasser, Ingrid, Schmid, Simone, Kuechler, Petra, Naisbitt, Dean

“…Hypersensitivity reactions to drugs can cause a variety of skin diseases like maculopapular, bullous and pustular eruptions. In recent years increasing…”
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The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice by Pickford, Fiona, Masliah, Eliezer, Britschgi, Markus, Lucin, Kurt, Narasimhan, Ramya, Jaeger, Philipp A, Small, Scott, Spencer, Brian, Rockenstein, Edward, Levine, Beth, Wyss-Coray, Tony

“…Autophagy is the principal cellular pathway for degradation of long-lived proteins and organelles and regulates cell fate in response to stress. Recently,…”
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