Search Results - "Britsch, Isabel"

Novel Fab-peptide-HLA-I fusion proteins for redirecting pre-existing anti-CMV T cell immunity to selectively eliminate carcinoma cells by Britsch, Isabel, van Wijngaarden, Anne P., Ke, Xiurong, Hendriks, Mark. A.J.M., Samplonius, Douwe F., Ploeg, Emily M., Helfrich, Wijnand

“…Typically, anticancer CD8 pos T cells occur at low frequencies and become increasingly impaired in the tumor micro environment. In contrast, antiviral CD8 pos…”
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Bispecific antibody approach for EGFR-directed blockade of the CD47-SIRPα "don't eat me" immune checkpoint promotes neutrophil-mediated trogoptosis and enhances antigen cross-presentation by Hendriks, Mark A. J. M., Ploeg, Emily M., Koopmans, Iris, Britsch, Isabel, Ke, Xiurong, Samplonius, Douwe F., Helfrich, Wijnand

“…Cancer cells overexpress CD47 to subvert phagocytic elimination and evade immunogenic processing of cancer antigens. Moreover, CD47 overexpression inhibits the…”
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Bispecific antibody CD73xEGFR more selectively inhibits the CD73/adenosine immune checkpoint on cancer cells and concurrently counteracts pro-oncogenic activities of CD73 and EGFR by Ploeg, Emily Maria, Samplonius, Douwe Freerk, Xiong, Xiao, Ke, Xiurong, Hendriks, Mark Alexander Johannes Martinus, Britsch, Isabel, van Wijngaarden, Anne Paulien, Zhang, Hao, Helfrich, Wijnand

“…Background CD73 is an ecto-enzyme that is involved in the conversion of pro-inflammatory extracellular ATP (eATP) excreted by cancer cells under stress to…”
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Cancer cells under immune attack acquire CD47-mediated adaptive immune resistance independent of the myeloid CD47-SIRPα axis by Hendriks, Mark A.J.M., Britsch, Isabel, Ke, Xiurong, van Wijngarden, Anne P., Samplonius, Douwe F., Ploeg, Emily M., Helfrich, Wijnand

“…Cancer cells exploit CD47 overexpression to inhibit phagocytic elimination and neoantigen processing via the myeloid CD47-SIRPα axis and thereby indirectly…”
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Applications of Anti-Cytomegalovirus T Cells for Cancer (Immuno)Therapy by Britsch, Isabel, van Wijngaarden, Anne Paulien, Helfrich, Wijnand

“…Infection with cytomegalovirus (CMV) is highly prevalent in the general population and largely controlled by CD8 T cells. Intriguingly, anti-CMV T cells…”
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Bispecific antibody CD73xEpCAM selectively inhibits the adenosine-mediated immunosuppressive activity of carcinoma-derived extracellular vesicles by Ploeg, Emily M., Ke, Xiurong, Britsch, Isabel, Hendriks, Mark A.J.M., Van der Zant, Femke A., Kruijff, Schelto, Samplonius, Douwe F., Zhang, Hao, Helfrich, Wijnand

“…Tumor-derived extracellular vesicles (EVs) carry potent immunosuppressive factors that affect the antitumor activities of immune cells. A significant part of…”
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A Novel Bispecific Antibody for EpCAM-Directed Inhibition of the CD73/Adenosine Immune Checkpoint in Ovarian Cancer by Ploeg, Emily Maria, Britsch, Isabel, van Wijngaarden, Anne Paulien, Ke, Xiurong, Hendriks, Mark Alexander Johannes Martinus, Samplonius, Douwe Freerk, Helfrich, Wijnand

“…PD-1/PD-L1-inhibiting antibodies have shown disappointing efficacy in patients with refractory ovarian cancer (OC). Apparently, OC cells exploit nonoverlapping…”
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Novel Fab-peptide-HLA-I fusion proteins for redirecting pre-existing anti-CMV T cell immunity to selective eliminate carcinoma cells by Britsch, Isabel, van Wijngaarden, Anne P, Ke, Xiurong, Hendriks, Mark A J M, Samplonius, Douwe F, Ploeg, Emily M, Helfrich, Wijnand

“…Typically, anticancer CD8 T cells occur at low frequencies and become increasingly impaired in the tumor micro environment. In contrast, antiviral CD8 T cells…”
Get full text