Search Results - "Brito, Marcelo A. M."
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High proportions of asymptomatic and submicroscopic Plasmodium vivax infections in a peri-urban area of low transmission in the Brazilian Amazon
Published in Parasites & vectors (20-03-2018)“…Population-based studies conducted in Latin America have shown a high proportion of asymptomatic and submicroscopic malarial infections. Considering efforts…”
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2
Real-life implementation of a G6PD deficiency screening qualitative test into routine vivax malaria diagnostic units in the Brazilian Amazon (SAFEPRIM study)
Published in PLoS neglected tropical diseases (18-05-2021)“…Glucose-6-phosphate dehydrogenase (G6PD) deficiency greatly hinders Plasmodium vivax malaria radical cure and further elimination due to…”
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3
G6PD deficiency in Latin America: systematic review on prevalence and variants
Published in Memórias do Instituto Oswaldo Cruz (01-08-2014)“…Plasmodium vivax radical cure requires the use of primaquine (PQ), a drug that induces haemolysis in glucose-6-phosphate dehydrogenase deficient (G6PDd)…”
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4
Plasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence
Published in Nature communications (02-06-2020)“…Plasmodium vivax is the most widely distributed human malaria parasite. Previous studies have shown that circulating microparticles during P. vivax acute…”
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Morphological and Transcriptional Changes in Human Bone Marrow During Natural Plasmodium vivax Malaria Infections
Published in The Journal of infectious diseases (01-04-2022)“…Abstract Background The presence of Plasmodium vivax malaria parasites in the human bone marrow (BM) is still controversial. However, recent data from a…”
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Influence of CYP2C8 , CYP3A4 , and CYP3A5 Host Genotypes on Early Recurrence of Plasmodium vivax
Published in Antimicrobial agents and chemotherapy (23-06-2020)“…Cytochrome P450 (CYP) enzymes are involved in the biotransformation of chloroquine (CQ), but the role of the different profiles of metabolism of this drug in…”
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Cost-effectiveness analysis of rapid diagnostic tests for G6PD deficiency in patients with Plasmodium vivax malaria in the Brazilian Amazon
Published in Malaria journal (11-02-2016)“…The use of primaquine (PQ) for radical treatment of Plasmodium vivax in carriers of G6PD deficiency (G6PDd) constitutes the main factor associated with severe…”
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Single-Dose Tafenoquine to Prevent Relapse of Plasmodium vivax Malaria
Published in The New England journal of medicine (17-01-2019)“…Clearing of the dormant liver stage (the hypnozoite) of P. vivax malaria is important to prevent the relapse of infection. In this randomized clinical trial, a…”
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Tafenoquine versus Primaquine to Prevent Relapse of Plasmodium vivax Malaria
Published in The New England journal of medicine (17-01-2019)“…Malaria remains a global health burden. Elimination of the hypnozoite is required in patients infected with P. vivax to prevent relapse. In this report, the…”
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High frequency of diabetes and impaired fasting glucose in patients with glucose-6-phosphate dehydrogenase deficiency in the Western brazilian Amazon
Published in The American journal of tropical medicine and hygiene (01-07-2014)“…Glucose-6-phosphate dehydrogenase (G6PD) deficiency is one of the most common human genetic abnormalities, and it has a significant prevalence in the male…”
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G6PD deficiency in male individuals infected by Plasmodium vivax malaria in the Brazilian Amazon: a cost study
Published in Malaria journal (24-03-2015)“…Deficiency of the enzyme G6PD (G6PDd) is caused by mutations in the gene G6PD, which plays an important role in protecting the red blood cell against oxidizing…”
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Plasmodium vivax gametocytes in the bone marrow of an acute malaria patient and changes in the erythroid miRNA profile
Published in PLoS neglected tropical diseases (06-04-2017)“…The presence of P. vivax in the bone marrow was first noticed in the late 19th century [2], and examinations of sternal bone marrow aspirates were performed as…”
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