Insights into the Antimicrobial Activity of Hydrated Cobaltmolybdate Doped with Copper

Molybdates are biocidal materials that can be useful in coating surfaces that are susceptible to contamination and the spread of microorganisms. The aim of this work was to investigate the effects of copper doping of hydrated cobalt molybdate, synthesized by the co-precipitation method, on its antib...

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Bibliographic Details
Published in:	Molecules (Basel, Switzerland) Vol. 26; no. 5; p. 1267
Main Authors:	Silva, Layane A L, Silva, André A L, Rios, Maria A S, Brito, Manoel P, Araújo, Alyne R, Silva, Durcilene A, Peña-Garcia, Ramón R, Silva-Filho, Edson C, Magalhães, Janildo L, Matos, José M E, Osajima, Josy A, Triboni, Eduardo R
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 26-02-2021 MDPI
Subjects:	Anti-Infective Agents - chemistry Anti-Infective Agents - pharmacology Antibacterial activity Antimicrobial activity Antimicrobial agents Bacteria Bacterial Infections - drug therapy Beta phase Biocides Calorimetry co-precipitation Cobalt Cobalt - chemistry Contamination Coordination Complexes - chemistry Copper Copper - chemistry Coronaviruses COVID-19 Differential scanning calorimetry Doping E coli Escherichia coli Escherichia coli - drug effects Fourier analysis Gram-positive bacteria Humans Infrared analysis Metal Nanoparticles - chemistry Microbial Sensitivity Tests Microemulsions Microorganisms Minimum inhibitory concentration Molybdate Molybdates Molybdenum - chemistry Particle Size Phase transitions Severe acute respiratory syndrome coronavirus 2 Spectroscopy Staphylococcus aureus Staphylococcus aureus - drug effects Strains (organisms) Thermogravimetric analysis co-precipitation Escherichia coli Staphylococcus aureus
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Summary:	Molybdates are biocidal materials that can be useful in coating surfaces that are susceptible to contamination and the spread of microorganisms. The aim of this work was to investigate the effects of copper doping of hydrated cobalt molybdate, synthesized by the co-precipitation method, on its antibacterial activity and to elucidate the structural and morphological changes caused by the dopant in the material. The synthesized materials were characterized by PXRD, Fourier Transformed Infrared (FTIR), thermogravimetric analysis/differential scanning calorimetry (TG/DSC), and SEM-Energy Dispersive Spectroscopy (SEM-EDS). The antibacterial response of the materials was verified using the Minimum Inhibitory Concentration (MIC) employing the broth microdilution method. The size of the CoMoO ·1.03H O microparticles gradually increased as the percentage of copper increased, decreasing the energy that is needed to promote the transition from the hydrated to the beta phase and changing the color of material. CoMoO ·1.03H O obtained better bactericidal performance against the tested strains of (gram-positive) than (gram-negative). However, an interesting point was that the use of copper as a doping agent for hydrated cobalt molybdate caused an increase of MIC value in the presence of and strains. The study demonstrates the need for caution in the use of copper as a doping material in biocidal matrices, such as cobalt molybdate.
ISSN:	1420-3049 1420-3049
DOI:	10.3390/molecules26051267