Search Results - "Brito, Luis A."

Impact of lipid nanoparticle size on mRNA vaccine immunogenicity by Hassett, Kimberly J., Higgins, Jaclyn, Woods, Angela, Levy, Becca, Xia, Yan, Hsiao, Chiaowen Joyce, Acosta, Edward, Almarsson, Örn, Moore, Melissa J., Brito, Luis A.

“…Lipid nanoparticles (LNP) are effective delivery vehicles for messenger RNA (mRNA) and have shown promise for vaccine applications. Yet there are no published…”
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Preclinical and Clinical Demonstration of Immunogenicity by mRNA Vaccines against H10N8 and H7N9 Influenza Viruses by Bahl, Kapil, Senn, Joe J., Yuzhakov, Olga, Bulychev, Alex, Brito, Luis A., Hassett, Kimberly J., Laska, Michael E., Smith, Mike, Almarsson, Örn, Thompson, James, Ribeiro, Amilcar (Mick), Watson, Mike, Zaks, Tal, Ciaramella, Giuseppe

“…Recently, the World Health Organization confirmed 120 new human cases of avian H7N9 influenza in China resulting in 37 deaths, highlighting the concern for a…”
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Overview of Vaccine Adjuvants: Introduction, History, and Current Status by Shah, Ruchi R, Hassett, Kimberly J, Brito, Luis A

“…Adjuvants are included in sub-unit or recombinant vaccines to enhance the potency of poorly immunogenic antigens. Adjuvant discovery is as complex as it is a…”
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Efficient Targeting and Activation of Antigen-Presenting Cells In Vivo after Modified mRNA Vaccine Administration in Rhesus Macaques by Liang, Frank, Lindgren, Gustaf, Lin, Ang, Thompson, Elizabeth A., Ols, Sebastian, Röhss, Josefine, John, Shinu, Hassett, Kimberly, Yuzhakov, Olga, Bahl, Kapil, Brito, Luis A., Salter, Hugh, Ciaramella, Giuseppe, Loré, Karin

“…mRNA vaccines are rapidly emerging as a powerful platform for infectious diseases because they are well tolerated, immunogenic, and scalable and are built on…”
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Optimization of Lipid Nanoparticles for Intramuscular Administration of mRNA Vaccines by Hassett, Kimberly J., Benenato, Kerry E., Jacquinet, Eric, Lee, Aisha, Woods, Angela, Yuzhakov, Olga, Himansu, Sunny, Deterling, Jessica, Geilich, Benjamin M., Ketova, Tatiana, Mihai, Cosmin, Lynn, Andy, McFadyen, Iain, Moore, Melissa J., Senn, Joseph J., Stanton, Matthew G., Almarsson, Örn, Ciaramella, Giuseppe, Brito, Luis A.

“…mRNA vaccines have the potential to tackle many unmet medical needs that are unable to be addressed with conventional vaccine technologies. A potent and…”
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Nonviral delivery of self-amplifying RNA vaccines by Geall, Andrew J, Verma, Ayush, Otten, Gillis R, Shaw, Christine A, Hekele, Armin, Banerjee, Kaustuv, Cu, Yen, Beard, Clayton W, Brito, Luis A, Krucker, Thomas, O’Hagan, Derek T, Singh, Manmohan, Mason, Peter W, Valiante, Nicholas M, Dormitzer, Philip R, Barnett, Susan W, Rappuoli, Rino, Ulmer, Jeffrey B, Mandl, Christian W

“…Despite more than two decades of research and development on nucleic acid vaccines, there is still no commercial product for human use. Taking advantage of the…”
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A Cationic Nanoemulsion for the Delivery of Next-generation RNA Vaccines by Brito, Luis A, Chan, Michelle, Shaw, Christine A, Hekele, Armin, Carsillo, Thomas, Schaefer, Mary, Archer, Jacob, Seubert, Anja, Otten, Gillis R, Beard, Clayton W, Dey, Antu K, Lilja, Anders, Valiante, Nicholas M, Mason, Peter W, Mandl, Christian W, Barnett, Susan W, Dormitzer, Philip R, Ulmer, Jeffrey B, Singh, Manmohan, O'Hagan, Derek T, Geall, Andrew J

“…Nucleic acid-based vaccines such as viral vectors, plasmid DNA, and mRNA are being developed as a means to address a number of unmet medical needs that current…”
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The impact of size on particulate vaccine adjuvants by Shah, Ruchi R, O'Hagan, Derek T, Amiji, Mansoor M, Brito, Luis A

“…Particulate adjuvants have been successful at inducing increased immune responses against many poorly immunogenic antigens. However, the mechanism of action of…”
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Induction of Robust B Cell Responses after Influenza mRNA Vaccination Is Accompanied by Circulating Hemagglutinin-Specific ICOS+ PD-1+ CXCR3+ T Follicular Helper Cells by Lindgren, Gustaf, Ols, Sebastian, Liang, Frank, Thompson, Elizabeth A, Lin, Ang, Hellgren, Fredrika, Bahl, Kapil, John, Shinu, Yuzhakov, Olga, Hassett, Kimberly J, Brito, Luis A, Salter, Hugh, Ciaramella, Giuseppe, Loré, Karin

“…Modified mRNA vaccines have developed into an effective and well-tolerated vaccine platform that offers scalable and precise antigen production. Nevertheless,…”
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Generation of a parvovirus B19 vaccine candidate by Chandramouli, Sumana, Medina-Selby, Angelica, Coit, Doris, Schaefer, Mary, Spencer, Terika, Brito, Luis A, Zhang, Pu, Otten, Gillis, Mandl, Christian W, Mason, Peter W, Dormitzer, Philip R, Settembre, Ethan C

“…Highlights • New MF59-adjuvanted parvovirus B19 vaccine candidate raises anti-viral antibodies in mice. • Mouse Ab titers are similar to those in human…”
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Vectored co-delivery of human cytomegalovirus gH and gL proteins elicits potent complement-independent neutralizing antibodies by Loomis, Rebecca J, Lilja, Anders E, Monroe, James, Balabanis, Kara A, Brito, Luis A, Palladino, Giuseppe, Franti, Michael, Mandl, Christian W, Barnett, Susan W, Mason, Peter W

“…Abstract Human cytomegalovirus (hCMV) is prevalent worldwide with infection generally being asymptomatic. Nevertheless, hCMV infection can lead to significant…”
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Novel approaches for vaccine development by Gebre, Makda S., Brito, Luis A., Tostanoski, Lisa H., Edwards, Darin K., Carfi, Andrea, Barouch, Dan H.

“…Vaccines are critical tools for maintaining global health. Traditional vaccine technologies have been used across a wide range of bacterial and viral…”
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Acceptable levels of endotoxin in vaccine formulations during preclinical research by Brito, Luis A, Singh, Manmohan

“…This brief commentary reviews endotoxin levels of commercial vaccines and puts them into context for the preclinical researcher working in vaccines. Vaccines…”
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Designing and building the next generation of improved vaccine adjuvants by Brito, Luis A, O'Hagan, Derek T

“…Vaccine adjuvants interact with the immune system, to increase the potency of vaccine antigens. Many of the adjuvants currently available were developed with…”
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Corrigendum: Induction of Robust B Cell Responses After Influenza mRNA Vaccination Is Accompanied by Circulating Hemagglutinin-Specific ICOS+ PD-1+ CXCR3+ T Follicular Helper Cells by Lindgren, Gustaf, Ols, Sebastian, Liang, Frank, Thompson, Elizabeth A, Lin, Ang, Hellgren, Fredrika, Bahl, Kapil, John, Shinu, Yuzhakov, Olga, Hassett, Kimberly J, Brito, Luis A, Salter, Hugh, Ciaramella, Giuseppe, Loré, Karin

“…[This corrects the article DOI: 10.3389/fimmu.2017.01539.]…”
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Non-viral eNOS gene delivery and transfection with stents for the treatment of restenosis by Brito, Luis A, Chandrasekhar, Saradha, Little, Steven R, Amiji, Mansoor M

“…In this study, we have examined local non-viral gene delivery, transfection, and therapeutic efficacy of endothelial nitric oxide synthase (eNOS) encoding…”
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Vaccine adjuvant formulations: A pharmaceutical perspective by Brito, Luis A, Malyala, Padma, O’Hagan, Derek T

“…Highlights • Formulation science is unappreciated and often overlooked in vaccinology. • Vaccine formulations should be stable, reproducible, robust and…”
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Nucleic acid vaccines: prospects for non-viral delivery of mRNA vaccines by Deering, Raquel P, Kommareddy, Sushma, Ulmer, Jeffrey B, Brito, Luis A, Geall, Andrew J

“…Nucleic acid-based vaccines are being developed as a means to combine the positive attributes of both live-attenuated and subunit vaccines. Viral vectors and…”
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Potent Immune Responses in Rhesus Macaques Induced by Nonviral Delivery of a Self-amplifying RNA Vaccine Expressing HIV Type 1 Envelope With a Cationic Nanoemulsion by Bogers, Willy M., Oostermeijer, Herman, Mooij, Petra, Koopman, Gerrit, Verschoor, Ernst J., Davis, David, Ulmer, Jeffrey B., Brito, Luis A., Cu, Yen, Banerjee, Kaustuv, Otten, Gillis R., Burke, Brian, Dey, Antu, Heeney, Jonathan L., Shen, Xiaoying, Tomaras, Georgia D., Labranche, Celia, Montefiori, David C., Liao, Hua-Xin, Haynes, Barton, Geall, Andrew J., Barnett, Susan W.

“…Self-amplifying messenger RNA (mRNA) of positive-strand RNA viruses are effective vectors for in situ expression of vaccine antigens and have potential as a…”
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The droplet size of emulsion adjuvants has significant impact on their potency, due to differences in immune cell-recruitment and -activation by Shah, Ruchi R., Taccone, Marianna, Monaci, Elisabetta, Brito, Luis A., Bonci, Alessandra, O’Hagan, Derek T., Amiji, Mansoor M., Seubert, Anja

“…Self-emulsification is routinely used for oral delivery of lipophilic drugs in vivo , with the emulsion forming in vivo . We modified this technique to prepare…”
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