Assessment of tear film osmolarity using the IPen®Vet osmometer in Pug and Shih‐Tzu dogs with and without keratoconjunctivitis sicca

Assessment of tear film osmolarity using the IPen®Vet osmometer in Pug and Shih‐Tzu dogs with and without keratoconjunctivitis sicca

Objective To establish tear film osmolarity (TFO) values in Pugs and Shih‐Tzus, with and without keratoconjunctivitis sicca (KCS). Animals studied A total of 82 adult dogs were evaluated. Procedure The inclusion criteria for the healthy group was a Schirmer tear test (STT‐1) ≥15 mm/min with no clini...

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Published in:Veterinary ophthalmology Vol. 25; no. 3; pp. 219 - 224
Main Authors: Brito, Fábio L. da C., Voitena, Jéssica N., Marinho, Tatiane O. C., Moore, Bret A., Montiani‐Ferreira, Fabiano
Format: Journal Article
Language:English
Published: England 01-05-2022
Subjects:
Animals
canine
Dog Diseases - diagnosis
Dogs
dry eye
Dry Eye Syndromes - veterinary
Humans
Keratoconjunctivitis Sicca - diagnosis
Keratoconjunctivitis Sicca - veterinary
Lacerations - veterinary
ocular surface
Osmolar Concentration
osmolarity
tear film
Tears
dogs
tear film
canine
dry eye
osmolarity
ocular surface
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Summary:Objective To establish tear film osmolarity (TFO) values in Pugs and Shih‐Tzus, with and without keratoconjunctivitis sicca (KCS). Animals studied A total of 82 adult dogs were evaluated. Procedure The inclusion criteria for the healthy group was a Schirmer tear test (STT‐1) ≥15 mm/min with no clinical signs of KCS, whereas those with KCS had clinical signs and a STT‐1 ≤10 mm/min. All animals underwent complete ophthalmological evaluation prior to STT‐1 and TFO. Student's t tests were used to compare STT‐1 and TFO in KCS and healthy eyes as well as possible differences in TFO between breeds. In addition, a linear regression to model the relationship between the two variables (STT‐1 and TFO) was performed. A P‐value ≤ 0.05 was considered statistically significant. Results STT‐1 results were significantly lower (p = 0.0001) in the KCS group (4.46 ± 1.74) compared with the control group (18.80 ± 2.02). Mean TFO results were significantly higher in the KCS group (353.02 ± 16.58 mOsm/L) (p < 0.0001) compared with the control group (315.27 ± 6.15 mOsm/L). The formula Y = 365.059–2.625 * X significantly predicts (p < 0.001) the value of the variable Y (TFO mOsm/L) as a function of the variable X (STT‐1 mm/min), with a coefficient of determination of 0.71. Conclusions The results revealed differences in TFO and STT‐1 between KCS and healthy dogs. Additionally, STT‐1 and TFO values were correlated with the aim to use STT‐1 values to predict TFO values in brachycephalic breeds.
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ISSN:1463-5216
1463-5224
DOI:10.1111/vop.12966