Search Results - "British journal of clinical pharmacology"

Recent developments of HDAC inhibitors: Emerging indications and novel molecules by Bondarev, Andrey D., Attwood, Misty M., Jonsson, Jörgen, Chubarev, Vladimir N., Tarasov, Vadim V., Schiöth, Helgi B.

“…The histone deacetylase (HDAC) enzymes, a class of epigenetic regulators, are historically well established as attractive therapeutic targets. During…”
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The pharmacokinetics and the pharmacodynamics of cannabinoids by Lucas, Catherine J., Galettis, Peter, Schneider, Jennifer

“…There is increasing interest in the use of cannabinoids for disease and symptom management, but limited information available regarding their pharmacokinetics…”
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The Medication Adherence Report Scale: A measurement tool for eliciting patients' reports of nonadherence by Chan, Amy Hai Yan, Horne, Rob, Hankins, Matthew, Chisari, Claudia

“…Aims This study aimed to establish the psychometric properties of a questionnaire measure of patients' adherence to medications to elicit patients' report of…”
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A systematic review of the emerging definition of ‘deprescribing’ with network analysis: implications for future research and clinical practice by Reeve, Emily, Gnjidic, Danijela, Long, Janet, Hilmer, Sarah

“…Aims The aim of this study was to identify what definitions have been published for the term ‘deprescribing’, and determine whether a unifying definition could…”
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Pharmacology of bisphosphonates by Cremers, Serge, Drake, Matthew T., Ebetino, F. Hal, Bilezikian, John P., Russell, R. Graham G.

“…The biological effects of the bisphosphonates (BPs) as inhibitors of calcification and bone resorption were first described in the late 1960s. In the 50 years…”
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The feasibility and effect of deprescribing in older adults on mortality and health: a systematic review and meta‐analysis by Page, Amy T., Clifford, Rhonda M., Potter, Kathleen, Schwartz, Darren, Etherton‐Beer, Christopher D.

“…Aims Deprescribing is a suggested intervention to reverse the potential iatrogenic harms of inappropriate polypharmacy. The review aimed to determine whether…”
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A systematic review of cannabidiol dosing in clinical populations by Millar, S.A., Stone, N.L., Bellman, Z.D., Yates, A.S., England, T.J., O'Sullivan, S.E.

“…Aims Cannabidiol (CBD) is a cannabis‐derived medicinal product with potential application in a wide‐variety of contexts; however, its effective dose in…”
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Adverse drug reactions in special populations – the elderly by Davies, E. A., O'Mahony, M. S.

“…The International Conference on Harmonization considers older people a ‘special population’, as they differ from younger adults in terms of comorbidity,…”
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Omega‐3 polyunsaturated fatty acids and inflammatory processes: nutrition or pharmacology? by Calder, Philip C.

“…Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are n‐3 fatty acids found in oily fish and fish oil supplements. These fatty acids are able to…”
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Immune‐mediated adverse reactions to vaccines by Stone, Cosby A., Rukasin, Christine R.F., Beachkofsky, Thomas M., Phillips, Elizabeth J.

“…Vaccination continues to be the single most important and successful public health intervention, due to its prevention of morbidity and mortality from…”
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Trends in the prescription of novel oral anticoagulants in UK primary care by Loo, Simone Y., Dell'Aniello, Sophie, Huiart, Laetitia, Renoux, Christel

“…Aims Novel oral anticoagulants (NOACs) are alternatives to vitamin‐K antagonists (VKAs) for the prevention of thromboembolism. It is unclear how NOACs have…”
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Microtubule destabilising agents: far more than just antimitotic anticancer drugs by Bates, Darcy, Eastman, Alan

“…Vinca alkaloids have been approved as anticancer drugs for more than 50 years. They have been classified as cytotoxic chemotherapy drugs that act during…”
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Degradation of the endothelial glycocalyx in clinical settings: searching for the sheddases by Becker, Bernhard F., Jacob, Matthias, Leipert, Stephanie, Salmon, Andrew H. J., Chappell, Daniel

“…The endothelial glycocalyx has a profound influence at the vascular wall on the transmission of shear stress, on the maintenance of a selective permeability…”
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The association between medication non‐adherence and adverse health outcomes in ageing populations: A systematic review and meta‐analysis by Walsh, Caroline A., Cahir, Caitriona, Tecklenborg, Sarah, Byrne, Catherine, Culbertson, Michael A., Bennett, Kathleen E.

“…Aims The aim of this systematic review and meta‐analysis was to synthesise the evidence relating to medication non‐adherence and its association with health…”
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Bioavailability of bioactive food compounds: a challenging journey to bioefficacy by Rein, Maarit J., Renouf, Mathieu, Cruz‐Hernandez, Cristina, Actis‐Goretta, Lucas, Thakkar, Sagar K., da Silva Pinto, Marcia

“…Bioavailability is a key step in ensuring bioefficacy of bioactive food compounds or oral drugs. Bioavailability is a complex process involving several…”
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AKT in cancer: new molecular insights and advances in drug development by Mundi, Prabhjot S., Sachdev, Jasgit, McCourt, Carolyn, Kalinsky, Kevin

“…The phosphatidylinositol‐3 kinase (PI3K)–AKT pathway is one of the most commonly dysregulated pathways in all of cancer, with somatic mutations, copy number…”
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Drugs with anticholinergic effects and cognitive impairment, falls and all‐cause mortality in older adults: A systematic review and meta‐analysis by Ruxton, Kimberley, Woodman, Richard J., Mangoni, Arduino A.

“…Aim The aim was to investigate associations between drugs with anticholinergic effects (DACEs) and cognitive impairment, falls and all‐cause mortality in older…”
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Defining ‘nutraceuticals’: neither nutritious nor pharmaceutical by Aronson, Jeffrey K.

“…There are widespread inconsistencies and contradictions in the many published definitions of ‘nutraceuticals’ and ‘functional foods’, demonstrating wholesale…”
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Safety and efficacy of fluvoxamine in COVID‐19 ICU patients: An open label, prospective cohort trial with matched controls by Calusic, Martina, Marcec, Robert, Luksa, Lea, Jurkovic, Ivan, Kovac, Natasa, Mihaljevic, Slobodan, Likic, Robert

“…Aims Fluvoxamine, a selective serotonin reuptake inhibitor (SSRI) and sigma‐1 receptor agonist, has so far shown promise in the prevention of COVID‐19…”
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Pharmacovigilance in low‐ and middle‐income countries: A review with particular focus on Africa by Kiguba, Ronald, Olsson, Sten, Waitt, Catriona

“…Low‐ and middle‐income countries (LMIC) face unique challenges with regard to the establishment of robust pharmacovigilance systems capable of generating data…”
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