Search Results - "Bristol, J. Andrew"

Development of SYN-004, an oral beta-lactamase treatment to protect the gut microbiome from antibiotic-mediated damage and prevent Clostridium difficile infection by Kaleko, Michael, Bristol, J. Andrew, Hubert, Steven, Parsley, Todd, Widmer, Giovanni, Tzipori, Saul, Subramanian, Poorani, Hasan, Nur, Koski, Perrti, Kokai-Kun, John, Sliman, Joseph, Jones, Annie, Connelly, Sheila

“…The gut microbiome, composed of the microflora that inhabit the gastrointestinal tract and their genomes, make up a complex ecosystem that can be disrupted by…”
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Nonclinical Safety Assessment of SYN-004: An Oral β-lactamase for the Protection of the Gut Microbiome From Disruption by Biliary-Excreted, Intravenously Administered Antibiotics by Kokai-Kun, John F., Bristol, J. Andrew, Setser, John, Schlosser, Michael

“…SYN-004 is a first in class, recombinant β-lactamase that degrades β-lactam antibiotics and has been formulated to be administered orally to patients receiving…”
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Tolerability and Pharmacokinetics of SYN-004, an Orally Administered β-Lactamase for the Prevention of Clostridium difficile-Associated Disease and Antibiotic-Associated Diarrhea, in Two Phase 1 Studies by Roberts, Tracey, Kokai-Kun, John F., Coughlin, Olivia, Lopez, Barbara Valero, Whalen, Heidi, Bristol, J. Andrew, Hubert, Steven, Longstreth, James, Lasseter, Kenneth, Sliman, Joseph

“…Background SYN-004 is an orally administered β-lactamase enzyme, designed to be given concurrently with certain intravenous β-lactam antibiotics like…”
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Linked Tumor-Selective Virus Replication and Transgene Expression from E3-Containing Oncolytic Adenoviruses by MINGZHU ZHU, BRISTOL, J. Andrew, YUEFENG XIE, MINA, Mervat, HONG JI, FORRY-SCHAUDIES, Suzanne, ENNIST, David L

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Potentiation of oncolytic adenoviral vector efficacy with gutless vectors encoding GMCSF or TRAIL by Burroughs, Kevin D, Kayda, Dawn B, Sakhuja, Kiran, Hudson, Yvette, Jakubczak, John, Bristol, J Andrew, Ennist, David, Hallenbeck, Paul, Kaleko, Michael, Connelly, Sheila

“…Oncolytic adenoviral vectors selectively replicate in and lyse human tumor cells, providing a promising means for targeted tumor destruction. However,…”
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In vitro and in vivo activities of an oncolytic adenoviral vector designed to express GM-CSF by Bristol, J.Andrew, Zhu, Mingzhu, Ji, Hong, Mina, Mervat, Xie, Yuefeng, Clarke, Lori, Forry-Schaudies, Suzanne, Ennist, David L

“…Oncolytic adenoviruses are being tested as biological cancer therapeutics. Ar6pAE2fF (E2F vector) contains the E2F-1 promoter to regulate the expression of the…”
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In Vivo Dose Threshold Effect of Adenovirus-Mediated Factor VIII Gene Therapy in Hemophiliac Mice by Bristol, J. Andrew, Shirley, Pamela, Idamakanti, Neeraja, Kaleko, Michael, Connelly, Sheila

“…While much is known about adenovirus biology from its development as a therapeutic gene delivery vehicle, an important question remains regarding the…”
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Biosynthesis of prothrombin : Intracellular localization of the vitamin K-dependent carboxylase and the sites of γ-carboxylation by ANDREW BRISTOL, J, RATCLIFFE, J. V, ROTH, D. A, JACOBS, M. A, FURIE, B. C, FURIE, B

“…Prothrombin is a vitamin K-dependent blood coagulation protein that undergoes posttranslational gamma-carboxylation and propeptide cleavage during…”
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Tu2054 SYN-004, a Clinical Stage Oral Beta-Lactamase Therapy, Protects the Intestinal Microflora from Antibiotic-Mediated Damage in Humanized Pigs by Connelly, Sheila, Widmer, Giovanni, Mukherjee, Jean, Huynh, Kevin, Bristol, J. Andrew, Hubert, Steven, Sliman, Joseph, Tzipori, Saul, Kaleko, Michael

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Tolerability and Pharmacokinetics of SYN-004, an Orally Administered [Beta]-Lactamase for the Prevention of Clostridium difficile-Associated Disease and Antibiotic-Associated Diarrhea, in Two Phase 1 Studies by Roberts, Tracey, Kokai-Kun, John F, Coughlin, Olivia, Lopez, Barbara Valero, Whalen, Heidi, Bristol, J Andrew, Hubert, Steven, Longstreth, James, Lasseter, Kenneth, Sliman, Joseph

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Regression of Extensive Pulmonary Metastases in Mice by Adoptive Transfer of Antigen-Specific CD8+ CTL Reactive Against Tumor Cells Expressing a Naturally Occurring Rejection Epitope by Ryan, Mary Hilburger, Bristol, J. Andrew, McDuffie, Elwood, Abrams, Scott I

“…In this study, we developed a mouse model of adoptive immunotherapy reflecting immune recognition of syngeneic tumor cells naturally expressing an endogenous…”
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Development of a Murine Mutant Ras CD8+ CTL Peptide Epitope Variant That Possesses Enhanced MHC Class I Binding and Immunogenic Properties by Bristol, J. Andrew, Schlom, Jeffrey, Abrams, Scott I

“…We recently identified a murine mutant Ras p21 CD8+ CTL epitope reflecting residues 4 to 12, containing the mutation of Gly to Val at codon 12, that bound…”
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Adenovirus-mediated factor VIII gene expression results in attenuated anti-factor VIII-specific immunity in hemophilia A mice compared with factor VIII protein infusion by Bristol, J A, Gallo-Penn, A, Andrews, J, Idamakanti, N, Kaleko, M, Connelly, S

“…Hemophilia A patients are typically treated by factor VIII (FVIII) protein replacement, an expensive therapy that induces FVIII-specific inhibitors in…”
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Identification of a ras Oncogene Peptide That Contains Both CD4+ and CD8+ T Cell Epitopes in a Nested Configuration and Elicits Both T Cell Subset Responses by Peptide or DNA Immunization by Bristol, J.Andrew, Orsini, Caroline, Lindinger, Peter, Thalhamer, Josef, Abrams, Scott I.

“…Mutations in ras proto-oncogenes are commonly found in a diversity of malignancies and may encode unique, non-self epitopes for T cell-mediated antitumor…”
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PACE/furin can process the vitamin K-dependent pro-factor IX precursor within the secretory pathway by WASLEY, L. C, REHEMTULLA, A, BRISTOL, J. A, KAUFMAN, R. J

“…Factor IX is synthesized as a precursor polypeptide which requires proteolytic cleavage of the propeptide for functional activity. Expression of factor IX at…”
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Persistence, Immune Specificity, and Functional Ability of Murine Mutant Ras Epitope-Specific CD4+ and CD8+ T Lymphocytes Following in Vivo Adoptive Transfer by Bristol, J.Andrew, Schlom, Jeffrey, Abrams, Scott I.

“…Adoptive T-cell transfer has been shown to be a potentially effective strategy for cellular immunotherapy in some murine models of disease. However, several…”
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Profactor IX: The propeptide inhibits binding to membrane surfaces and activation by factor XIA by Bristol, J. Andrew, Freedman, Steven J, Furie, Barbara C, Furie, Bruce

“…The gamma-carboxylase recognition site in the propeptide of profactor IX signals the gamma-carboxylation of specific glutamic acid residues in the adjacent Gla…”
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