Efficacy of fenbendazole and milbemycin oxime for treating baboons (Papio cynocephalus anubis) infected with Trichuris trichiura

We evaluated the efficacy of fenbendazole (FBZ) and milbemycin oxime (MO) in the treatment of baboons (Papio cynocephalus anubis) with naturally acquired Trichuris trichiura infection by comparing fecal egg count reduction (FECR) tests. We assigned 7 baboons, each singly housed and confirmed infecte...

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Bibliographic Details
Published in:	Journal of the American Association for Laboratory Animal Science Vol. 46; no. 2; p. 42
Main Authors:	Reichard, Mason V, Wolf, Roman F, Carey, David W, Garrett, Jennifer Jane, Briscoe, Heather A
Format:	Journal Article
Language:	English
Published:	United States 01-03-2007
Subjects:	Animals Antinematodal Agents - therapeutic use Fenbendazole - therapeutic use Macrolides - therapeutic use Monkey Diseases - drug therapy Monkey Diseases - parasitology Papio cynocephalus - parasitology Trichuriasis - drug therapy Trichuriasis - veterinary Trichuris - drug effects Trichuris - physiology
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Summary:	We evaluated the efficacy of fenbendazole (FBZ) and milbemycin oxime (MO) in the treatment of baboons (Papio cynocephalus anubis) with naturally acquired Trichuris trichiura infection by comparing fecal egg count reduction (FECR) tests. We assigned 7 baboons, each singly housed and confirmed infected with T. trichiura, to treatment groups of FBZ (n=3) or MO (n=3), or as a control (n=1). All (100%) baboons that received FBZ stopped shedding T. trichiura eggs within 6 d of treatment, and fecal egg counts remained negative at 65 d after treatment. Although the number of T. trichiura eggs shed per gram of feces from 2 (67%) baboons decreased significantly after the second treatment with MO, this regimen never totally eliminated eggs of T. trichiura. The results of our study indicate that FBZ was more effective for treating baboons with T. trichiura than was MO.
ISSN:	1559-6109