Search Results - "Brion, François"

Identification of Synthetic Steroids in River Water Downstream from Pharmaceutical Manufacture Discharges Based on a Bioanalytical Approach and Passive Sampling by Creusot, Nicolas, Aït-Aïssa, Selim, Tapie, Nathalie, Pardon, Patrick, Brion, François, Sanchez, Wilfried, Thybaud, Eric, Porcher, Jean-Marc, Budzinski, Hélène

“…A bioanalytical approach was used to identify chemical contaminants at river sites located downstream from a pharmaceutical factory, where reproductive…”
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In vitro and in vivo estrogenic activity of BPA, BPF and BPS in zebrafish-specific assays by Le Fol, Vincent, Aït-Aïssa, Selim, Sonavane, Manoj, Porcher, Jean-Marc, Balaguer, Patrick, Cravedi, Jean-Pierre, Zalko, Daniel, Brion, François

“…Bisphenol A (BPA) is a widely used chemical that has been extensively studied as an endocrine-disrupting chemical (EDC). Other bisphenols sharing close…”
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Effect-based trigger values for in vitro and in vivo bioassays performed on surface water extracts supporting the environmental quality standards (EQS) of the European Water Framework Directive by Escher, Beate I., Aїt-Aїssa, Selim, Behnisch, Peter A., Brack, Werner, Brion, François, Brouwer, Abraham, Buchinger, Sebastian, Crawford, Sarah E., Du Pasquier, David, Hamers, Timo, Hettwer, Karina, Hilscherová, Klára, Hollert, Henner, Kase, Robert, Kienle, Cornelia, Tindall, Andrew J., Tuerk, Jochen, van der Oost, Ron, Vermeirssen, Etienne, Neale, Peta A.

“…Effect-based methods including cell-based bioassays, reporter gene assays and whole-organism assays have been applied for decades in water quality monitoring…”
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Human and Zebrafish Nuclear Progesterone Receptors Are Differently Activated by Manifold Progestins by Garoche, Clémentine, Aït-Aïssa, Selim, Boulahtouf, Abdelhay, Creusot, Nicolas, Hinfray, Nathalie, Bourguet, William, Balaguer, Patrick, Brion, François

“…The environmental risk of natural and synthetic ligands of the nuclear progesterone receptor (nPR) has been pointed out, however there is still a lack of…”
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Integrating chemical analysis and bioanalysis to evaluate the contribution of wastewater effluent on the micropollutant burden in small streams by Neale, Peta A., Munz, Nicole A., Aїt-Aїssa, Selim, Altenburger, Rolf, Brion, François, Busch, Wibke, Escher, Beate I., Hilscherová, Klára, Kienle, Cornelia, Novák, Jiří, Seiler, Thomas-Benjamin, Shao, Ying, Stamm, Christian, Hollender, Juliane

“…Surface waters can contain a range of micropollutants from point sources, such as wastewater effluent, and diffuse sources, such as agriculture. Characterizing…”
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Mixture effects in samples of multiple contaminants – An inter-laboratory study with manifold bioassays by Altenburger, Rolf, Scholze, Martin, Busch, Wibke, Escher, Beate I., Jakobs, Gianina, Krauss, Martin, Krüger, Janet, Neale, Peta A., Ait-Aissa, Selim, Almeida, Ana Catarina, Seiler, Thomas-Benjamin, Brion, François, Hilscherová, Klára, Hollert, Henner, Novák, Jiří, Schlichting, Rita, Serra, Hélène, Shao, Ying, Tindall, Andrew, Tollefsen, Knut Erik, Umbuzeiro, Gisela, Williams, Tim D., Kortenkamp, Andreas

“…Chemicals in the environment occur in mixtures rather than as individual entities. Environmental quality monitoring thus faces the challenge to comprehensively…”
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Cell-Specific Biotransformation of Benzophenone‑2 and Bisphenol‑S in Zebrafish and Human in Vitro Models Used for Toxicity and Estrogenicity Screening by Le Fol, Vincent, Aït-Aïssa, Selim, Cabaton, Nicolas, Dolo, Laurence, Grimaldi, Marina, Balaguer, Patrick, Perdu, Elisabeth, Debrauwer, Laurent, Brion, François, Zalko, Daniel

“…Several human and fish bioassays have been designed to characterize the toxicity and the estrogenic activity of chemicals. However, their biotransformation…”
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Monitoring estrogenic activities of waste and surface waters using a novel in vivo zebrafish embryonic (EASZY) assay: Comparison with in vitro cell-based assays and determination of effect-based trigger values by Brion, François, De Gussem, Valentin, Buchinger, Sebastian, Hollert, Henner, Carere, Mario, Porcher, Jean-Marc, Piccini, Benjamin, Féray, Christine, Dulio, Valeria, Könemann, Sarah, Simon, Eszter, Werner, Inge, Kase, Robert, Aït-Aïssa, Selim

“…This study reports the use of the recently developed EASZY assay that uses transgenic cyp19a1b-GFP zebrafish (Danio rerio) embryos to assess in vivo estrogenic…”
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Screening estrogenic activities of chemicals or mixtures in vivo using transgenic (cyp19a1b-GFP) zebrafish embryos by Brion, François, Le Page, Yann, Piccini, Benjamin, Cardoso, Olivier, Tong, Sok-Keng, Chung, Bon-chu, Kah, Olivier

“…The tg(cyp19a1b-GFP) transgenic zebrafish expresses GFP (green fluorescent protein) under the control of the cyp19a1b gene, encoding brain aromatase. This gene…”
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Combined effects of environmental xeno-estrogens within multi-component mixtures: Comparison of in vitro human- and zebrafish-based estrogenicity bioassays by Serra, Hélène, Scholze, Martin, Altenburger, Rolf, Busch, Wibke, Budzinski, Hélène, Brion, François, Aït-Aïssa, Selim

“…Some recent studies showed that in vitro bioassays based on fish or human estrogen receptor (ER) activation may have distinct responses to environmental…”
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Development of a bioanalytical test battery for water quality monitoring: Fingerprinting identified micropollutants and their contribution to effects in surface water by Neale, Peta A., Altenburger, Rolf, Aït-Aïssa, Selim, Brion, François, Busch, Wibke, de Aragão Umbuzeiro, Gisela, Denison, Michael S., Du Pasquier, David, Hilscherová, Klára, Hollert, Henner, Morales, Daniel A., Novák, Jiří, Schlichting, Rita, Seiler, Thomas-Benjamin, Serra, Helene, Shao, Ying, Tindall, Andrew J., Tollefsen, Knut Erik, Williams, Timothy D., Escher, Beate I.

“…Surface waters can contain a diverse range of organic pollutants, including pesticides, pharmaceuticals and industrial compounds. While bioassays have been…”
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Differential activity of BPA, BPAF and BPC on zebrafish estrogen receptors in vitro and in vivo by Pinto, Caroline, Hao, Ruixin, Grimaldi, Marina, Thrikawala, Savini, Boulahtouf, Abdelhay, Aït-Aïssa, Selim, Brion, François, Gustafsson, Jan-Åke, Balaguer, Patrick, Bondesson, Maria

“…The high volume production compound bisphenol A (BPA) is of environmental concern largely because of its estrogenic activity. Consequently, BPA analogues have…”
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Aromatase in the brain of teleost fish: Expression, regulation and putative functions by Diotel, Nicolas, Page, Yann Le, Mouriec, Karen, Tong, Sok-Keng, Pellegrini, Elisabeth, Vaillant, Colette, Anglade, Isabelle, Brion, François, Pakdel, Farzad, Chung, Bon-chu, Kah, Olivier

“…Abstract Unlike that of mammals, the brain of teleost fish exhibits an intense aromatase activity due to the strong expression of one of two aromatase genes…”
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Metformin in Reproductive Biology by Faure, Melanie, Bertoldo, Michael J, Khoueiry, Rita, Bongrani, Alice, Brion, François, Giulivi, Cecilia, Dupont, Joelle, Froment, Pascal

“…Initially produced in Europe in 1958, metformin is still one of the most widely prescribed drugs to treat type II diabetes and other comorbidities associated…”
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ReadEDTest: A tool to assess the readiness of in vitro test methods under development for identifying endocrine disruptors by Crouzet, Thibault, Grignard, Elise, Brion, François, Blanc, Etienne B., Podechard, Normand, Langouet, Sophie, Alonso-Magdalena, Paloma, Hubert, Philippe, Kim, Min Ji, Audouze, Karine

“…Growing evidence shows that endocrine disruptors (EDs), known to affect the reproductive system, may also disturb other hormone-regulated functions leading to…”
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Adverse effects in wild fish living downstream from pharmaceutical manufacture discharges by Sanchez, Wilfried, Sremski, William, Piccini, Benjamin, Palluel, Olivier, Maillot-Maréchal, Emmanuelle, Betoulle, Stéphane, Jaffal, Ali, Aït-Aïssa, Sélim, Brion, François, Thybaud, Eric, Hinfray, Nathalie, Porcher, Jean-Marc

“…A set of biochemical and histological responses was measured in wild gudgeon collected upstream and downstream of urban and pharmaceutical manufacture…”
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European demonstration program on the effect-based and chemical identification and monitoring of organic pollutants in European surface waters by Tousova, Zuzana, Oswald, Peter, Slobodnik, Jaroslav, Blaha, Ludek, Muz, Melis, Hu, Meng, Brack, Werner, Krauss, Martin, Di Paolo, Carolina, Tarcai, Zsolt, Seiler, Thomas-Benjamin, Hollert, Henner, Koprivica, Sanja, Ahel, Marijan, Schollée, Jennifer E., Hollender, Juliane, Suter, Marc J.-F., Hidasi, Anita O., Schirmer, Kristin, Sonavane, Manoj, Ait-Aissa, Selim, Creusot, Nicolas, Brion, Francois, Froment, Jean, Almeida, Ana Catarina, Thomas, Kevin, Tollefsen, Knut Erik, Tufi, Sara, Ouyang, Xiyu, Leonards, Pim, Lamoree, Marja, Torrens, Victoria Osorio, Kolkman, Annemieke, Schriks, Merijn, Spirhanzlova, Petra, Tindall, Andrew, Schulze, Tobias

“…Growing concern about the adverse environmental and human health effects of a wide range of micropollutants requires the development of novel tools and…”
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Estrogenic potency of benzophenone UV filters in breast cancer cells: proliferative and transcriptional activity substantiated by docking analysis by Kerdivel, Gwenneg, Le Guevel, Remy, Habauzit, Denis, Brion, François, Ait-Aissa, Selim, Pakdel, Farzad

“…The results from recent studies show that some benzophenones (BPs) and their hydroxylated metabolites can function as weak estrogens (E2) in the environment…”
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A comparison of behavioral and reproductive parameters between wild-type, transgenic and mutant zebrafish: Could they all be considered the same “zebrafish” for reglementary assays on endocrine disruption? by De Oliveira, Julie, Chadili, Edith, Turies, Cyril, Brion, François, Cousin, Xavier, Hinfray, Nathalie

“…Transgenic zebrafish models are efficiently used to study the effects of endocrine disrupting chemicals (EDC); thereby informing on their mechanisms of action…”
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A Physiologically Based Toxicokinetic Model for the Zebrafish Danio rerio by Péry, Alexandre R. R, Devillers, James, Brochot, Céline, Mombelli, Enrico, Palluel, Olivier, Piccini, Benjamin, Brion, François, Beaudouin, Rémy

“…Zebrafish (Danio rerio) is a widely used model for toxicological studies, in particular those related to investigations on endocrine disruption. The…”
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