Search Results - "Brinkworth, Amanda J"

Manipulation of Focal Adhesion Signaling by Pathogenic Microbes by Murphy, Korinn N, Brinkworth, Amanda J

“…Focal adhesions (FAs) serve as dynamic signaling hubs within the cell. They connect intracellular actin to the extracellular matrix (ECM) and respond to…”
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Chlamydia trachomatis modulates the expression of JAK-STAT signaling components to attenuate the type II interferon response of epithelial cells by Fontanilla, Francis L, Ibana, Joyce A, Carabeo, Rey A, Brinkworth, Amanda J

“…has adapted to subvert signaling in epithelial cells to ensure successful intracellular development. Interferon-γ (IFNγ) produced by recruited lymphocytes…”
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Chlamydia trachomatis induces the transcriptional activity of host YAP in a Hippo-independent fashion by Caven, Liam T, Brinkworth, Amanda J, Carabeo, Rey A

“…The obligate intracellular pathogen Chlamydia trachomatis is the causative agent of the most common bacterial sexually transmitted disease worldwide. While the…”
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A bipartite iron-dependent transcriptional regulation of the tryptophan salvage pathway in Chlamydia trachomatis by Pokorzynski, Nick D, Brinkworth, Amanda J, Carabeo, Rey

“…During infection, pathogens are starved of essential nutrients such as iron and tryptophan by host immune effectors. Without conserved global stress response…”
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Identification of Outer Membrane and Exoproteins of Carbapenem-Resistant Multilocus Sequence Type 258 Klebsiella pneumoniae by Brinkworth, Amanda J, Hammer, Carl H, Olano, L Renee, Kobayashi, Scott D, Chen, Liang, Kreiswirth, Barry N, DeLeo, Frank R

“…Carbapenem-resistant Klebsiella pneumoniae strains have emerged as a cause of life-threatening infections in susceptible individuals (e.g., transplant…”
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Genomewide Transcriptional Responses of Iron-Starved Chlamydia trachomatis Reveal Prioritization of Metabolic Precursor Synthesis over Protein Translation by Brinkworth, Amanda J, Wildung, Mark R, Carabeo, Rey A

“…Iron is essential for growth and development of . Its long-term starvation in cultured mammalian cells leads to production of aberrant noninfectious chlamydial…”
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Phagocytosis and Killing of Carbapenem-Resistant ST258 Klebsiella pneumoniae by Human Neutrophils by Kobayashi, Scott D., Porter, Adeline R., Dorward, David W., Brinkworth, Amanda J., Chen, Liang, Kreiswirth, Barry N., DeLeo, Frank R.

“…Carbapenem-resistant Klebsiella pneumoniae strains classified as multilocus sequence type 258 (ST258) are among the most widespread multidrug-resistant…”
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Characterization of 6S RNA in the Lyme disease spirochete by Drecktrah, Dan, Hall, Laura S., Brinkworth, Amanda J., Comstock, Jeanette R., Wassarman, Karen M., Samuels, D. Scott

“…6S RNA binds to RNA polymerase and regulates gene expression, contributing to bacterial adaptation to environmental stresses. In this study, we examined the…”
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A post-invasion role for Chlamydia type III effector TarP in modulating the dynamics and organization of host cell focal adhesions by Pedrosa, António T., Murphy, Korinn N., Nogueira, Ana T., Brinkworth, Amanda J., Thwaites, Tristan R., Aaron, Jesse, Chew, Teng-Leong, Carabeo, Rey A.

“…The human pathogen Chlamydia trachomatis targets epithelial cells lining the genital mucosa. We observed that infection of various cell types, including…”
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In Vitro and In Vivo Activity of (Trifluoromethyl)pyridines as Anti-Chlamydia trachomatis Agents by Seleem, Mohamed A, Wood, Nicholas A, Brinkworth, Amanda J, Manam, Srikanth, Carabeo, Rey A, Murthy, Ashlesh K, Ouellette, Scot P, Conda-Sheridan, Martin

“…Chlamydia trachomatis is the leading pathogen in sexually transmitted bacterial infections across the globe. The development of a selective treatment against…”
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Chlamydia trachomatis Slc1 is a type III secretion chaperone that enhances the translocation of its invasion effector substrate TARP by Brinkworth, Amanda J., Malcolm, Denise S., Pedrosa, António T., Roguska, Katarzyna, Shahbazian, Sevanna, Graham, James E., Hayward, Richard D., Carabeo, Rey A.

“…Summary Bacterial type III secretion system (T3SS) chaperones pilot substrates to the export apparatus in a secretion‐competent state, and are consequently…”
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Genomewide Transcriptional Responses of Iron-Starved Chlamydia trachomatis Reveal Prioritization of Metabolic Precursor Synthesis over Protein Translation by Amanda J. Brinkworth, Mark R. Wildung, Rey A. Carabeo

“…ABSTRACT Iron is essential for growth and development of Chlamydia. Its long-term starvation in cultured mammalian cells leads to production of aberrant…”
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Identification of Outer Membrane and Exoproteins of Carbapenem-Resistant Multilocus Sequence Type 258 Klebsiella pneumoniae: e0123219 by Brinkworth, Amanda J, Hammer, Carl H, Olano, L Renee, Kobayashi, Scott D, Chen, Liang, Kreiswirth, Barry N, DeLeo, Frank R

“…Carbapenem-resistant Klebsiella pneumoniae strains have emerged as a cause of life-threatening infections in susceptible individuals (e.g., transplant…”
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Identification and biochemical characterization of the Chlamydia trachomatis type III secretion chaperone, Slc1, and its role in the translocation of the invasion-associated effector TARP by Brinkworth, Amanda J

“…Chlamydia trachomatis is an obligate intracellular pathogen that utilizes a type III secretion system to enter mammalian cells and establish an intracellular…”
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Identification and biochemical characterization of the Chlamydia trachomatis type III secretion chaperone, Slc1, and its role in the translocation of the invasion-associated effector TARP by Brinkworth, Amanda J

“…Chlamydia trachomatis is an obligate intracellular pathogen that utilizes a type III secretion system to enter mammalian cells and establish an intracellular…”
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