Search Results - "Brinkmann, Albert O"

Molecular mechanisms of androgen action--a historical perspective by Brinkmann, Albert O

“…Androgens and the androgen receptor (AR) are indispensable for expression of the male phenotype. The two most important androgens are testosterone and…”
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Targeted Disruption of the Insl3 Gene Causes Bilateral Cryptorchidism by Zimmermann, Stephan, Steding, Gerd, Emmen, Judith M. A, Brinkmann, Albert O, Nayernia, Karim, Holstein, Adolf F, Engel, Wolfgang, Adham, Ibrahim M

“…The sexual dimorphic position of the gonads in mammals is dependent on differential development of two ligaments, the cranial suspensory ligament (CSL) and the…”
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A Polymorphism in the Glucocorticoid Receptor Gene, Which Decreases Sensitivity to Glucocorticoids In Vivo, Is Associated With Low Insulin and Cholesterol Levels by VAN ROSSUM, Elisabeth F. C, KOPER, Jan W, LAMBERTS, Steven W. J, HUIZENGA, Nannette A. T. M, UITTERLINDEN, André G, JANSSEN, Joop A. M. J. L, BRINKMANN, Albert O, GROBBEE, Diederick E, DE JONG, Frank H, VAN DUYN, Cornelia M, POLS, Huibert A. P

“…A Polymorphism in the Glucocorticoid Receptor Gene, Which Decreases Sensitivity to Glucocorticoids In Vivo, Is Associated With Low Insulin and Cholesterol…”
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Broadened ligand responsiveness of androgen receptor mutants obtained by random amino acid substitution of H874 and mutation hot spot T877 in prostate cancer by Steketee, Karine, Timmerman, Leon, Ziel‐van der Made, Angelique C.J., Doesburg, Paul, Brinkmann, Albert O., Trapman, Jan

“…In a subset of endocrine therapy‐resistant prostate cancers, amino acid substitutions H874Y, T877A and T877S, which broaden ligand specificity of the ligand…”
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Distinct Recognition Modes of FXXLF and LXXLL Motifs by the Androgen Receptor by Dubbink, Hendrikus J, Hersmus, Remko, Verma, Chandra S, van der Korput, Hetty A. G. M, Berrevoets, Cor A, van Tol, Judith, Ziel-van der Made, Angelique C. J, Brinkmann, Albert O, Pike, Ashley C. W, Trapman, Jan

“…Among nuclear receptors, the androgen receptor (AR) is unique in that its ligand-binding domain (LBD) interacts with the FXXLF motif in the N-terminal domain,…”
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Associations between promoter usage and alternative splicing of the glucocorticoid receptor gene by Russcher, Henk, Dalm, Virgil A S H, de Jong, Frank H, Brinkmann, Albert O, Hofland, Leo J, Lamberts, Steven W J, Koper, Jan W

“…The glucocorticoid receptor (GR) is widely expressed in various tissues throughout the human body. At least three different 3′-splice variants of the GR have…”
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Recruitment of the Androgen Receptor via Serum Response Factor Facilitates Expression of a Myogenic Gene by Vlahopoulos, Spiros, Zimmer, Warren E, Jenster, Guido, Belaguli, Narasimhaswamy S, Balk, Steven P, Brinkmann, Albert O, Lanz, Rainer B, Zoumpourlis, Vassilis C, Schwartz, Robert J

“…Androgen receptor (AR) induced precocious myogenesis in culture and myogenic specified gene activity. Increased levels of AR expression in replicating C2C12…”
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Characterization of a promoter polymorphism in the glucocorticoid receptor gene and its relationship to three other polymorphisms by Van Rossum, Elisabeth F. C., Roks, Petronella H. M., De Jong, Frank H., Brinkmann, Albert O., Pols, Huib A. P., Koper, Jan W., Lamberts, Steven W. J.

“…Summary objective  Sensitivity to glucocorticoids within the normal population is highly variable and partly determined by polymorphisms in the glucocorticoid…”
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Phosphorylation of androgen receptor isoforms by Wong, Hao Yun, Burghoorn, Jan A, Van Leeuwen, Marije, De Ruiter, Petra E, Schippers, Esther, Blok, Leen J, Li, Ka Wan, Dekker, Henk L, De Jong, Luitzen, Trapman, Jan, Grootegoed, J Anton, Brinkmann, Albert O

“…Phosphorylation of the human AR (androgen receptor) is directly correlated with the appearance of at least three AR isoforms on an SDS/polyacrylamide gel…”
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Consequences of Loss of Progesterone Receptor Expression in Development of Invasive Endometrial Cancer by HANEKAMP, Eline E, GIELEN, Susanne C. J. P, BLOK, Leen J, SMID-KOOPMAN, Ellen, KÜHNE, Liesbeth C. M, DE RUITER, Petra E, CHADHA-AJWANI, Savi, BRINKMANN, Albert O, GROOTEGOED, J. Anton, BURGER, Curt W, HUIKESHOVEN, Frans J

“…Purpose: In endometrial cancer, loss of progesterone receptors (PR) is associated with more advanced disease. This study aimed to investigate the mechanism of…”
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Functional in Vivo Interaction between the Amino-Terminal, Transactivation Domain and the Ligand Binding Domain of the Androgen Receptor by Doesburg, Paul, Kuil, Cor W, Berrevoets, Cor A, Steketee, Karine, Faber, Peter W, Mulder, Eppo, Brinkmann, Albert O, Trapman, Jan

“…The ligand binding domain (LBD) and the amino-terminal, transactivation domain (TAD) of the androgen receptor (AR) were separately linked to the GAL4 DNA…”
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Proteomic analysis of proteins regulated by TRPS1 transcription factor in DU145 prostate cancer cells by Chang, Glenn T.G., Gamble, Simon C., Jhamai, Mila, Wait, Robin, Bevan, Charlotte L., Brinkmann, Albert O.

“…The aim of the present study was to identify proteins differentially regulated by TRPS1 in human prostate cancer cells in order to better understand the role…”
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The TRPS1 transcription factor: androgenic regulation in prostate cancer and high expression in breast cancer by Chang, Glenn T G, Jhamai, Mila, van Weerden, Wytske M, Jenster, Guido, Brinkmann, Albert O

“…TRPS1 mRNA is more highly expressed in androgen-dependent lymph node carcinoma of prostate-fast growing colony (LNCaP-FGC) compared with androgen-independent…”
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Two Polymorphisms in the Glucocorticoid Receptor Gene Directly Affect Glucocorticoid-Regulated Gene Expression by Russcher, Henk, Smit, Pauline, van den Akker, Erica L. T., van Rossum, Elisabeth F. C., Brinkmann, Albert O., de Jong, Frank H., Lamberts, Steven W. J., Koper, Jan W.

“…Context: Interindividual variation in glucocorticoid (GC)-sensitivity can be partly explained by polymorphisms in the GC receptor (GR) gene. The ER22/23EK and…”
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Identification of the BclI polymorphism in the glucocorticoid receptor gene: association with sensitivity to glucocorticoids in vivo and body mass index by Van Rossum, Elisabeth F. C., Koper, Jan W., Van Den Beld, Annewieke W., Uitterlinden, André G., Arp, Pascal, Ester, Wietske, Janssen, Joop A. M. J. L., Brinkmann, Albert O., De Jong, Frank H., Grobbee, Diederick E., Pols, Huibert A. P., J. Lamberts, Steven W.

“…Summary objective  Sensitivity to glucocorticoids differs between individuals, partially due to genetic variation in the glucocorticoid receptor (GR) gene. We…”
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Clinical and molecular spectrum of somatic mosaicism in androgen insensitivity syndrome by HOLTERHUS, P.-M, WIEBEL, J, SINNECKER, G. H. G, BRÜGGENWIRTH, H. T, SIPPELL, W. G, BRINKMANN, A. O, KRUSE, K, HIORT, O

“…We recently found that postzygotic de novo mutations occur at the expected high rate of an X-linked recessive mutation in androgen insensitivity syndrome. The…”
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Glucocorticoid Receptor Polymorphism Affects Transrepression But Not Transactivation by van den Akker, Erica L. T., Russcher, Henk, van Rossum, Elisabeth F. C., Brinkmann, Albert O., de Jong, Frank H., Hokken, Anita, Pols, Huibert A. P., Koper, Jan W., Lamberts, Steven W. J.

“…Context: Glucocorticoids (GCs) are extensively used in the treatment of inflammatory and autoimmune diseases. Their beneficial effects are thought to be…”
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Increased Expression of the Glucocorticoid Receptor-A Translational Isoform as a Result of the ER22/23EK Polymorphism by Russcher, Henk, van Rossum, Elisabeth F. C, de Jong, Frank H, Brinkmann, Albert O, Lamberts, Steven W. J, Koper, Jan W

“…One of the most intriguing polymorphisms in the GR [glucocorticoid (GC) receptor] gene is in codons 22 and 23 [GAGAGG(GluArg) → GAAAAG (GluLys)]. This…”
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Phosphotryptic Peptide Analysis of the Human Androgen Receptor: Detection of a Hormone-Induced Phosphopeptide by Kuiper, George G. J. M, Brinkmann, Albert O

“…Phosphorylation of the androgen receptor (AR) in human prostate tumor cells (LNCaP) is increased by androgens. The AR is expressed as two isoforms with…”
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Androgen Receptor Ligand-Binding Domain Interaction and Nuclear Receptor Specificity of FXXLF and LXXLL Motifs as Determined by L/F Swapping by Dubbink, Hendrikus J, Hersmus, Remko, Pike, Ashley C. W, Molier, Michel, Brinkmann, Albert O, Jenster, Guido, Trapman, Jan

“…The androgen receptor (AR) ligand-binding domain (LBD) binds FXXLF motifs, present in the AR N-terminal domain and AR-specific cofactors, and some LXXLL motifs…”
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