Search Results - "Brinkman, C Colin"

Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration by Brinkman, C. Colin, Iwami, Daiki, Hritzo, Molly K., Xiong, Yanbao, Ahmad, Sarwat, Simon, Thomas, Hippen, Keli L., Blazar, Bruce R., Bromberg, Jonathan S.

“…Regulatory T cells (Tregs) are essential to suppress unwanted immunity or inflammation. After islet allo-transplant Tregs must migrate from blood to allograft,…”
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Regulation of T cell afferent lymphatic migration by targeting LTβR-mediated non-classical NFκB signaling by Piao, Wenji, Xiong, Yanbao, Famulski, Konrad, Brinkman, C. Colin, Li, Lushen, Toney, Nicholas, Wagner, Chelsea, Saxena, Vikas, Simon, Thomas, Bromberg, Jonathan S.

“…Lymphotoxin-beta receptor (LTβR) signaling in lymphatic endothelial cells (LEC) regulates leukocyte afferent lymphatic transendothelial migration (TEM). The…”
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Interleukin-10 From Marginal Zone Precursor B-Cell Subset Is Required for Costimulatory Blockade-Induced Transplantation Tolerance by Lal, Girdhari, Nakayama, Yumi, Sethi, Apoorva, Singh, Amit K, Burrell, Bryna E, Kulkarni, Neeraja, Brinkman, C Colin, Iwami, Daiki, Zhang, Tianshu, Bromberg, Jonathan S

“…Blocking CD40-CD40L costimulatory signals induces transplantation tolerance. Although B-cell depletion prevents alloantibody formation, nonhumoral functions of…”
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CD4 T cell sphingosine 1-phosphate receptor (S1PR)1 and S1PR4 and endothelial S1PR2 regulate afferent lymphatic migration by Xiong, Yanbao, Piao, Wenji, Brinkman, C Colin, Li, Lushen, Kulinski, Joseph M, Olivera, Ana, Cartier, Andreane, Hla, Timothy, Hippen, Keli L, Blazar, Bruce R, Schwab, Susan R, Bromberg, Jonathan S

“…Sphingosine 1-phosphate (S1P) and S1P receptors (S1PRs) regulate migration of lymphocytes out of thymus to blood and lymph nodes (LNs) to efferent lymph,…”
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Microbiota—implications for immunity and transplantation by Bromberg, Jonathan S., Fricke, W. Florian, Brinkman, C. Colin, Simon, Thomas, Mongodin, Emmanuel F.

“…Key Points Measuring the microbiome and/or microbiota is challenging; new bioinformatic techniques are becoming available that can help identify patterns in…”
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IL-10 from marginal zone precursor B cells controls the differentiation of Th17, Tfh and Tfr cells in transplantation tolerance by Lal, Girdhari, Kulkarni, Neeraja, Nakayama, Yumi, Singh, Amit K, Sethi, Apoorva, Burrell, Bryna E, Brinkman, C. Colin, Iwami, Daiki, Zhang, Tianshu, Hehlgans, Thomas, Bromberg, Jonathan S

“…Highlights • Depletion of B cells prevents co-stimulatory blockade induced transplantation tolerance. • Depletion of B cells or deficiency of IL-10 in B cell…”
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A robust in vitro model for trans-lymphatic endothelial migration by Xiong, Yanbao, Brinkman, C. Colin, Famulski, Konrad S, Mongodin, Emmanuel F., Lord, Colin J., Hippen, Keli L., Blazar, Bruce R., Bromberg, Jonathan S.

“…Trans-endothelial migration (TEM) is essential for leukocyte circulation. While much is known about trans-blood endothelial migration, far less is known about…”
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Author Correction: Regulation of T cell afferent lymphatic migration by targeting LTβR-mediated non-classical NFκB signaling by Piao, Wenji, Xiong, Yanbao, Famulski, Konrad, Brinkman, C. Colin, Li, Lushen, Toney, Nicholas, Wagner, Chelsea, Saxena, Vikas, Simon, Thomas, Bromberg, Jonathan S.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Peripheral tissue homing receptor control of naïve, effector, and memory CD8 T cell localization in lymphoid and non-lymphoid tissues by Brinkman, C Colin, Peske, J David, Engelhard, Victor Henry

“…T cell activation induces homing receptors that bind ligands on peripheral tissue vasculature, programing movement to sites of infection and injury. There are…”
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Complete Genome Sequence of a Strain of Bifidobacterium pseudolongum Isolated from Mouse Feces and Associated with Improved Organ Transplant Outcome by Mongodin, Emmanuel F, Hittle, Lauren L, Nadendla, Suvarna, Brinkman, C Colin, Xiong, Yanbao, Bromberg, Jonathan S

“…Here, we report the complete genome sequence of strain UMB-MBP-01, isolated from the feces of C57BL/6J mice. This strain was identified in microbiome profiling…”
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T-bet Regulates Natural Regulatory T Cell Afferent Lymphatic Migration and Suppressive Function by Xiong, Yanbao, Ahmad, Sarwat, Iwami, Daiki, Brinkman, C Colin, Bromberg, Jonathan S

“…T-bet is essential for natural regulatory T cells (nTreg) to regulate Th1 inflammation, but whether T-bet controls other Treg functions after entering the…”
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Vascular Endothelial Growth Factor C/Vascular Endothelial Growth Factor Receptor 3 Signaling Regulates Chemokine Gradients and Lymphocyte Migration From Tissues to Lymphatics by Iwami, Daiki, Brinkman, C Colin, Bromberg, Jonathan S

“…BACKGROUNDCirculation of leukocytes via blood, tissue and lymph is integral to adaptive immunity. Afferent lymphatics form CCL21 gradients to guide dendritic…”
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Strategies and challenges in eliciting immunity to melanoma by Ferguson, Andrew R, Nichols, Lisa A, Zarling, Angela L, Thompson, Elizabeth D, Brinkman, C. Colin, Hargadon, Kristian M, Bullock, Timothy N, Engelhard, Victor H

“…The ability of CD8⁺ T cells to recognize melanoma tumors has led to the development of immunotherapeutic approaches that use the antigens CD8⁺ T cells…”
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Differential Regulation of T-cell Immunity and Tolerance by Stromal Laminin Expressed in the Lymph Node by Simon, Thomas, Li, Lushen, Wagner, Chelsea, Zhang, Tianshu, Saxena, Vikas, Brinkman, C Colin, Tostanoski, Lisa H, Ostrand-Rosenberg, Suzanne, Jewell, Chris, Shea-Donohue, Terez, Hippen, Keli, Blazar, Bruce, Abdi, Reza, Bromberg, Jonathan S

“…BACKGROUND.Stromal laminins α4 and α5 are differentially regulated in transplant tolerance and immunity, respectively, resulting in altered T-cell trafficking…”
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Murine Fibroblastic Reticular Cells From Lymph Node Interact With CD4+ T Cells Through CD40-CD40L by Nakayama, Yumi, Brinkman, C Colin, Bromberg, Jonathan S

“…Costimulatory blockade with anti-CD40L monoclonal antibody (mAb) plus donor-specific splenocyte transfusion (DST) induces alloantigen-specific tolerance. We…”
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Regulatory T cell induction, migration, and function in transplantation by Burrell, Bryna E, Nakayama, Yumi, Xu, Jiangnan, Brinkman, C Colin, Bromberg, Jonathan S

“…Regulatory T cells (Treg) are important in maintaining immune homeostasis and in regulating a variety of immune responses, making them attractive targets for…”
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Treg tissue stability depends on lymphotoxin beta-receptor- and adenosine-receptor-driven lymphatic endothelial cell responses by Saxena, Vikas, Piao, Wenji, Li, Lushen, Paluskievicz, Christina, Xiong, Yanbao, Simon, Thomas, Lakhan, Ram, Brinkman, C. Colin, Walden, Sarah, Hippen, Keli L., WillsonShirkey, Marina, Lee, Young S., Wagner, Chelsea, Blazar, Bruce R., Bromberg, Jonathan S.

“…Regulatory T cell (Treg) lymphatic migration is required for resolving inflammation and prolonging allograft survival. Focusing on Treg interactions with…”
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Lymph Node Stromal Fiber ER-TR7 Modulates CD4+ T Cell Lymph Node Trafficking and Transplant Tolerance by Burrell, Bryna E, Warren, Kristi J, Nakayama, Yumi, Iwami, Daiki, Brinkman, C Colin, Bromberg, Jonathan S

“…BACKGROUNDTrafficking and differentiation of naive CD4+ and regulatory T cells (Treg) within the lymph node (LN) are integral for tolerance induction. The LN…”
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Biological sensors shed light on ligand geography by Brinkman, C Colin, Bromberg, Jonathan S

“…Small, soluble, ubiquitous ligands are difficult to visualize. Schwab and colleagues have created a functional receptor reporter that gauges the in vivo…”
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Peripheral tissue homing receptors enable T cell entry into lymph nodes and affect the anatomical distribution of memory cells by Brinkman, C Colin, Rouhani, Sherin J, Srinivasan, Nithya, Engelhard, Victor H

“…Peripheral tissue homing receptors enable T cells to access inflamed nonlymphoid tissues. In this study, we show that two such molecules, E-selectin ligand and…”
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