Search Results - "Brinkman, Brigitta M.N."

Characterization of salivary RNA by cDNA library analysis by Park, Noh Jin, Zhou, Xiaofeng, Yu, Tianwei, Brinkman, Brigitta M.N, Zimmermann, Bernhard G, Palanisamy, Visswanathan, Wong, David T

“…Abstract Oral fluid (saliva) meets the demands for a noninvasive and accessible diagnostic medium. Recent reports by our group and others described the…”
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Characterization of RNA in Saliva by Park, Noh Jin, Li, Yang, Yu, Tianwei, Brinkman, Brigitta M.N, Wong, David T

“…We have previously shown that human mRNAs are present in saliva and can be used as biomarkers of oral cancer. In this study, we analyzed the integrity,…”
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TNF- α promoter polymorphisms, production and susceptibility to multiple sclerosis in different groups of patients by Huizinga, Tom W.J, Westendorp, Rudi G.J, Bollen, Eduard L.E.M, Keijsers, Vivian, Brinkman, Brigitta M.N, Langermans, Jan A.M, Breedveld, Ferdinand C, Verweij, Cornelis L, van de Gaer, Luc, Dams, Lieve, Crusius, J.Bart A, Garcı́a-Gonzalez, Asunción, van Oosten, Bob W, Polman, Chris H, Peña, A.Salvador

“…TNF- α production in whole blood cultures upon stimulation with LPS was determined in 179 individuals from 61 families in order to characterise the magnitude…”
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Splice variants as cancer biomarkers by Brinkman, Brigitta M.N.

“…Inherited and acquired changes in pre-mRNA splicing have been documented to play a significant role in human disease development and many cancer-associated…”
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Polymorphism within the tumor necrosis factor α (TNF) promoter region in patients with ankylosing spondylitis by Kaijzel, Eric L, Brinkman, Brigitta M.N, van Krugten, Michiel V, Smith, Louise, Huizinga, Tom W.J, Verjans, Georges M.G.M, Breedveld, Ferdinand C, Verweij, Cornelis L

“…In addition to HLA-B27, other genetic factors are thought to be involved in the pathogenesis of ankylosing spondylitis (AS). Because of the location of the TNF…”
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Disease mechanism and biomarkers of oral squamous cell carcinoma by Brinkman, Brigitta MN, Wong, David TW

“…PURPOSE OF REVIEWThis review focuses on oral cancer disease mechanisms and discusses ongoing research to identify molecular signatures or biomarkers for oral…”
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RNAprotect saliva: An optimal room- temperature stabilization reagent for the salivary transcriptome by Park, Noh Jin, Yu, Tianwei, Nabili, Vishad, Brinkman, Brigitta M N, Henry, Sharon, Wang, Jianghua, Wong, David T

“…Translational and clinical applications of salivary transcriptome diagnostics require RNA degradation in saliva to be stopped at the time of collection and…”
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Stimulus-Specific Assembly of Enhancer Complexes on the Tumor Necrosis Factor Alpha Gene Promoter by Falvo, James V., Uglialoro, Adele M., Brinkman, Brigitta M. N., Merika, Menie, Parekh, Bhavin S., Tsai, Eunice Y., King, Hadley C., Morielli, Anthony D., Peralta, Ernest G., Maniatis, Tom, Thanos, Dimitris, Goldfeld, Anne E.

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Engagement of Tumor Necrosis Factor (TNF) Receptor 1 Leads to ATF-2- and p38 Mitogen-activated Protein Kinase-dependent TNF-α Gene Expression by Brinkman, Brigitta M.N., Telliez, Jean-Baptiste, Schievella, Andrea R., Lin, Lih-Ling, Goldfeld, Anne E.

“…Engagement of the tumor necrosis factor-α (TNF-α) receptors by the TNF-α ligand results in the rapid induction of TNF-α gene expression. The study presented…”
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A Stimulus-Specific Role for CREB-Binding Protein (CBP) in T Cell Receptor-Activated Tumor Necrosis Factor α Gene Expression by Falvo, James V., Brigitta M. N. Brinkman, Tsytsykova, Alla V., Tsai, Eunice Y., Yao, Tso-Pang, Kung, Andrew L., Goldfeld, Anne E.

“…The cAMP response element binding protein (CREB)-binding protein (CBP)/p300 family of coactivator proteins regulates gene transcription through the integration…”
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The tetracycline derivative minocycline differentially affects cytokine production by monocytes and T lymphocytes by KLOPPENBURG, M, BRINKMAN, B. M. N, DE ROOIJ-DIJK, H. H, MILTENBURG, A. M. M, DAHA, M. R, BREEDVELD, F. C, DIJKMANS, B. A. C, VERWEIJ, C. L

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Polymorphisms within the Human Tumor Necrosis Factor-α Promoter Region in Human Immunodeficiency Virus Type 1-Seropositive Persons by Brinkman, Brigitta M. N., Keet, Ireneus P. M., Miedema, Frank, Verweij, Cor L., Klein, Michèl R.

“…The question is addressed whether particular tumor necrosis factor-α (TNF-α) polymorphisms are associated with clinical course and outcome of human…”
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Signaling through the lymphotoxin-beta receptor stimulates HIV-1 replication alone and in cooperation with soluble or membrane-bound TNF-alpha by Marshall, W L, Brinkman, B M, Ambrose, C M, Pesavento, P A, Uglialoro, A M, Teng, E, Finberg, R W, Browning, J L, Goldfeld, A E

“…The level of ongoing HIV-1 replication within an individual is critical to HIV-1 pathogenesis. Among host immune factors, the cytokine TNF-alpha has previously…”
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Detection of a C-insertion polymorphism within the human tumor necrosis factor alpha (TNFA) gene by BRINKMAN, B. M. N, KAIJZEL, E. L, HUIZINGA, T. W. J, GIPHART, M. J, BREEDVELD, F. C, VERWEIJ, C. L

“…We have identified a C-insertion polymorphism in the 5'UTR of the first exon of the human tumor necrosis factor alpha (TNFA) gene. TNFA is a cytokine that…”
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Allele-specific quantification of TNFA transcripts in rheumatoid arthritis by BRINKMAN, B. M. N, HUIZINGA, T. W. J, BREEDVELD, F. C, VERWEIJ, C. L

“…Clinical and laboratory studies have suggested a pivotal role for tumor necrosis factor alpha (TNFA) in the pathogenesis of rheumatoid arthritis (RA)…”
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Tumor necrosis factor alpha-308 gene variants in relation to major histocompatibility complex alleles and Felty's syndrome by Brinkman, B M, Giphart, M J, Verhoef, A, Kaijzel, E L, Naipal, A M, Daha, M R, Breedveld, F C, Verweij, C L

“…The location of the human TNF genes within the MHC complex has prompted much speculation about the role of TNF alleles in the etiology of MHC-associated…”
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Detection of intracellular interferon-gamma by light microscopy using an immunoperoxidase technique: correlation with the corresponding mRNA and protein product by Dolhain, R J, Andersson, U, ter Haar, N T, Brinkman, B M, Verweij, C L, Daha, M R, Breedveld, F C, Miltenburg, A M

“…Identifying individual cytokine-producing cells may help to acquire insight into immunological processes. This study was designed to adapt a technique for the…”
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Expression of granzymes A and B in synovial tissue from patients with rheumatoid arthritis and osteoarthritis by Kummer, J A, Tak, P P, Brinkman, B M, van Tilborg, A A, Kamp, A M, Verweij, C L, Daha, M R, Meinders, A E, Hack, C E, Breedveld, F C

“…Granzymes A and B are serine proteinases which are stored in the granules of activated cytotoxic T cells and NK cells. Expression of these granzymes by…”
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