Search Results - "Brinkman, Brigitta"

Heterogeneity of the gut microbiome in mice: guidelines for optimizing experimental design by Laukens, Debby, Brinkman, Brigitta M., Raes, Jeroen, De Vos, Martine, Vandenabeele, Peter

“…Targeted manipulation of the gut flora is increasingly being recognized as a means to improve human health. Yet, the temporal dynamics and intra- and…”
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Characterization of RNA in Saliva by Park, Noh Jin, Li, Yang, Yu, Tianwei, Brinkman, Brigitta M.N, Wong, David T

“…We have previously shown that human mRNAs are present in saliva and can be used as biomarkers of oral cancer. In this study, we analyzed the integrity,…”
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Severity of doxorubicin-induced small intestinal mucositis is regulated by the TLR-2 and TLR-9 pathways by Kaczmarek, Agnieszka, Brinkman, Brigitta M, Heyndrickx, Liesbeth, Vandenabeele, Peter, Krysko, Dmitri V

“…Intestinal mucositis is a serious complication of cancer chemotherapy and radiotherapy; it frequently compromises treatment and dramatically reduces the…”
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S57 Impact of the HLA-DQA105 Allele on Ustekinumab Loss of Response, Anti-drug Antibodies, and Concentration in Patients With Inflammatory Bowel Disease by Colombel, Jean-Frederic, Martín-Arranz, María D, Brinkman, Brigitta, Gasink, Christopher, Guan, Meijian, Hart, Amy, Ahmad, Tariq

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Splice variants as cancer biomarkers by Brinkman, Brigitta M.N.

“…Inherited and acquired changes in pre-mRNA splicing have been documented to play a significant role in human disease development and many cancer-associated…”
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Gut microbiota affects sensitivity to acute DSS-induced colitis independently of host genotype by Brinkman, Brigitta M, Becker, Anne, Ayiseh, Rene B, Hildebrand, Falk, Raes, Jeroen, Huys, Geert, Vandenabeele, Peter

“…Caspase-deficient mice and wild-type (WT) mice show significant differences in their gut microbiota composition. These differences coincide with the…”
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Tauroursodeoxycholic acid inhibits experimental colitis by preventing early intestinal epithelial cell death by Laukens, Debby, Devisscher, Lindsey, Van den Bossche, Lien, Hindryckx, Pieter, Vandenbroucke, Roosmarijn E, Vandewynckel, Yves-Paul, Cuvelier, Claude, Brinkman, Brigitta M, Libert, Claude, Vandenabeele, Peter, De Vos, Martine

“…Ulcerative colitis (UC) is characterized by increased epithelial cell death and subsequent breakdown of the intestinal epithelial barrier, which perpetuates…”
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Disease mechanism and biomarkers of oral squamous cell carcinoma by Brinkman, Brigitta MN, Wong, David TW

“…PURPOSE OF REVIEWThis review focuses on oral cancer disease mechanisms and discusses ongoing research to identify molecular signatures or biomarkers for oral…”
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Characterization of salivary RNA by cDNA library analysis by Park, Noh Jin, Zhou, Xiaofeng, Yu, Tianwei, Brinkman, Brigitta M.N, Zimmermann, Bernhard G, Palanisamy, Visswanathan, Wong, David T

“…Abstract Oral fluid (saliva) meets the demands for a noninvasive and accessible diagnostic medium. Recent reports by our group and others described the…”
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RNAprotect saliva: An optimal room- temperature stabilization reagent for the salivary transcriptome by Park, Noh Jin, Yu, Tianwei, Nabili, Vishad, Brinkman, Brigitta M N, Henry, Sharon, Wang, Jianghua, Wong, David T

“…Translational and clinical applications of salivary transcriptome diagnostics require RNA degradation in saliva to be stopped at the time of collection and…”
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The skin microbiome of caspase-14-deficient mice shows mild dysbiosis by Kubica, Malgorzata, Hildebrand, Falk, Brinkman, Brigitta M., Goossens, Dirk, Del Favero, Jurgen, Vercammen, Ken, Cornelis, Pierre, Schröder, Jens-Michael, Vandenabeele, Peter, Raes, Jeroen, Declercq, Wim

“…Caspase‐14, an important proteinase involved in filaggrin catabolism, is mainly active in terminally differentiating keratinocytes, where it is required for…”
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Stimulus-Specific Assembly of Enhancer Complexes on the Tumor Necrosis Factor Alpha Gene Promoter by Falvo, James V., Uglialoro, Adele M., Brinkman, Brigitta M. N., Merika, Menie, Parekh, Bhavin S., Tsai, Eunice Y., King, Hadley C., Morielli, Anthony D., Peralta, Ernest G., Maniatis, Tom, Thanos, Dimitris, Goldfeld, Anne E.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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M1751 Oxygen Sensor Inhibition Attenuates TNF-α Induced Intestinal Epithelial Damage by Hypoxia Inducible Factor (HIF) 1-Dependent Repression of Fas-Associated Death Domain Protein (Fadd) by Hindryckx, Pieter, De Vos, Martine, Jacques, Peggy, Ferdinande, Liesbeth, Peeters, Harald, Brinkman, Brigitta M, Vandenabeele, Peter, Elewaut, Dirk, Laukens, Debby

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A Stimulus-Specific Role for CREB-Binding Protein (CBP) in T Cell Receptor-Activated Tumor Necrosis Factor α Gene Expression by Falvo, James V., Brigitta M. N. Brinkman, Tsytsykova, Alla V., Tsai, Eunice Y., Yao, Tso-Pang, Kung, Andrew L., Goldfeld, Anne E.

“…The cAMP response element binding protein (CREB)-binding protein (CBP)/p300 family of coactivator proteins regulates gene transcription through the integration…”
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TNF- α promoter polymorphisms, production and susceptibility to multiple sclerosis in different groups of patients by Huizinga, Tom W.J, Westendorp, Rudi G.J, Bollen, Eduard L.E.M, Keijsers, Vivian, Brinkman, Brigitta M.N, Langermans, Jan A.M, Breedveld, Ferdinand C, Verweij, Cornelis L, van de Gaer, Luc, Dams, Lieve, Crusius, J.Bart A, Garcı́a-Gonzalez, Asunción, van Oosten, Bob W, Polman, Chris H, Peña, A.Salvador

“…TNF- α production in whole blood cultures upon stimulation with LPS was determined in 179 individuals from 61 families in order to characterise the magnitude…”
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Inflammation-associated enterotypes, host genotype, cage and inter-individual effects drive gut microbiota variation in common laboratory mice by Hildebrand, Falk, Nguyen, Thi Loan Anh, Brinkman, Brigitta, Yunta, Roberto Garcia, Cauwe, Benedicte, Vandenabeele, Peter, Liston, Adrian, Raes, Jeroen

“…BACKGROUND: Murine models are a crucial component of gut microbiome research. Unfortunately, a multitude of genetic backgrounds and experimental setups,…”
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HLA-DQA105 Not Associated With Ustekinumab Loss of Response and Antidrug Antibodies in Ulcerative Colitis and Crohn’s Disease Patients by Colombel, Jean-Frédéric, Martín-Arranz, María D, Brinkman, Brigitta, Guan, Meijian, Hart, Amy, Gasink, Christopher

“…Lay Summary It is unknown if inflammatory bowel disease patients carrying the HLA-DQA1*05 allele have a greater risk of immunogenicity to ustekinumab. We…”
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Polymorphisms within the Human Tumor Necrosis Factor-α Promoter Region in Human Immunodeficiency Virus Type 1-Seropositive Persons by Brinkman, Brigitta M. N., Keet, Ireneus P. M., Miedema, Frank, Verweij, Cor L., Klein, Michèl R.

“…The question is addressed whether particular tumor necrosis factor-α (TNF-α) polymorphisms are associated with clinical course and outcome of human…”
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Polymorphism within the tumor necrosis factor α (TNF) promoter region in patients with ankylosing spondylitis by Kaijzel, Eric L, Brinkman, Brigitta M.N, van Krugten, Michiel V, Smith, Louise, Huizinga, Tom W.J, Verjans, Georges M.G.M, Breedveld, Ferdinand C, Verweij, Cornelis L

“…In addition to HLA-B27, other genetic factors are thought to be involved in the pathogenesis of ankylosing spondylitis (AS). Because of the location of the TNF…”
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Hydroxylase inhibition abrogates TNF-alpha-induced intestinal epithelial damage by hypoxia-inducible factor-1-dependent repression of FADD by Hindryckx, Pieter, De Vos, Martine, Jacques, Peggy, Ferdinande, Liesbeth, Peeters, Harald, Olievier, Kim, Bogaert, Sara, Brinkman, Brigitta, Vandenabeele, Peter, Elewaut, Dirk, Laukens, Debby

“…Hydroxylase inhibitors stabilize hypoxia-inducible factor-1 (HIF-1), which has barrier-protective activity in the gut. Because the inflammatory cytokine TNF-α…”
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