Search Results - "Brinkley, Bill R"

Aurora kinase-A regulates kinetochore/chromatin associated microtubule assembly in human cells by Katayama, Hiroshi, Sasai, Kaori, Kloc, Malgorzata, Brinkley, Bill R., Sen, Subrata

“…Microtubule nucleation and formation from the kinetochore/chromatin have been proposed to contribute to bipolar spindle assembly facilitating equal segregation…”
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Aurora-C and Aurora-B share phosphorylation and regulation of cenp-A and borealin during mitosis by Slattery, Scott D., Moore, Rebecca V., Brinkley, Bill R., Hall, Rebecca M.

“…Aurora-B and -C kinases are members of the Aurora serine/threonine kinase family of mitotic regulators. Aurora-B kinase is evolutionarily conserved from yeast…”
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A framework for image-based classification of mitotic cells in asynchronous populations by Slattery, Scott D, Newberg, Justin Y, Szafran, Adam T, Hall, Rebecca M, Brinkley, Bill R, Mancini, Michael A

“…High content screening (HCS) has emerged an important tool for drug discovery because it combines rich readouts of cellular responses in a single experiment…”
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Mitotic checkpoints, MUGs and kinetochores by Brinkley, Bill R

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Aurora-C kinase supports mitotic progression in the absence of Aurora-B by Slattery, Scott D, Mancini, Michael A, Brinkley, Bill R, Hall, Rebecca M

“…Aurora family kinases regulate numerous mitotic processes, and their dysfunction or overexpression can cause aneuploidy, a contributing factor for…”
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Aurora-C kinase supports mitotic progression in the absence of Aurora-B by Slattery, Scott D., Mancini, Michael A., Brinkley, Bill R., Hall, Rebecca M.

“…Aurora family kinases regulate numerous mitotic processes, and their dysfunction or overexpression can cause aneuploidy, a contributing factor for…”
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An inducible mouse model for skin cancer reveals distinct roles for gain- and loss-of-function p53 mutations by Caulin, Carlos, Nguyen, Thao, Lang, Gene A, Goepfert, Thea M, Brinkley, Bill R, Cai, Wei-Wen, Lozano, Guillermina, Roop, Dennis R

“…Mutations in ras and p53 are the most prevalent mutations found in human nonmelanoma skin cancers. Although some p53 mutations cause a loss of function, most…”
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Expression of a p53 mutant in the epidermis of transgenic mice accelerates chemical carcinogenesis by WANG, X.-J, GREENHALGH, D. A, AIBO JIANG, DACHENG HE, LING ZHONG, MEDINA, D, BRINKLEY, B. R, ROOP, D. R

“…To develop an in vivo model for studying the role of the p53 tumor suppressor in skin carcinogenesis, a murine p53(172H) mutant (equivalent to human p53(175H))…”
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NudC Is Required for Plk1 Targeting to the Kinetochore and Chromosome Congression by Nishino, Michiya, Kurasawa, Yasuhiro, Evans, Randall, Lin, Sue-Hwa, Brinkley, Bill R., Yu-Lee, Li-yuan

“…The equal distribution of chromosomes during mitosis is critical for maintaining the integrity of the genome. Essential to this process are the capture of…”
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Aberrant cell cycle progression contributes to the early-stage accelerated carcinogenesis in transgenic epidermis expressing the dominant negative TGFβRII by GO, C, WEI HE, LING ZHONG, PING LI, JUAN HUANG, BRINKLEY, B. R, WANG, X.-J

“…Mutations in the transforming growth factor β type II receptor (TGFβRII) have been found in various malignant tumors, suggesting that loss of TGFβ signaling…”
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Managing the centrosome numbers game: from chaos to stability in cancer cell division by Brinkley, Bill R

“…Aneuploid tumor cells can arise through multipolar mitosis caused by supernumerary centrosomes. Multipolar spindles, however, are antagonistic to cell…”
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Tumour amplified kinase STK15 / BTAK induces centrosome amplification, aneuploidy and transformation by Sen, Subrata, Zhou, Hongyi, Kuang, Jian, Zhong, Ling, Kuo, Wen-lin, Gray, Joe, Sahin, Aysegul, Brinkley, Bill

“…The centrosomes are thought to maintain genomic stability through the establishment of bipolar spindles during cell division, ensuring equal segregation of…”
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CENP-G: a new centromeric protein that is associated with the ?-1 satellite DNA subfamily by He, Dacheng, Zeng, Changqing, Woods, Karen, Turner, Donna, Busch, Rose K., Brinkley, Bill R., Busch, Harris, Zhong, Ling

“…A new constitutive centromere-specific protein (CENP) has been identified as a result of its recognition as an autoantigen by serum from a patient with gastric…”
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Aurora‐C phosphorylates and regulates Borealin and CENP‐A during mitosis by Slattery, Scott Dunning, Moore, Rebecca V, Brinkley, Bill R, MacCorkle, Rebecca A

“…Abstract only Aurora‐B and –C kinases are members of the Aurora serine/threonine kinase family of mitotic regulators. Aurora‐B kinase is evolutionarily…”
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CENP‐E, a novel human centromere‐associated protein required for progression from metaphase to anaphase by Yen, T. J., Compton, D. A., Wise, D., Zinkowski, R. P., Brinkley, B. R., Earnshaw, W. C., Cleveland, D. W.

“…We have identified a novel human centromere‐associated protein by preparing monoclonal antibodies against a fraction of HeLa chromosome scaffold proteins…”
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CENP-G: a new centromeric protein that is associated with the alpha-1 satellite DNA subfamily by He, D, Zeng, C, Woods, K, Zhong, L, Turner, D, Busch, R K, Brinkley, B R, Busch, H

“…A new constitutive centromere-specific protein (CENP) has been identified as a result of its recognition as an autoantigen by serum from a patient with gastric…”
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Aberrant cell cycle progression contributes to the early-stage accelerated carcinogenesis in transgenic epidermis expressing the dominant negative TGF[beta]RII by Go, Cindy, He, Wei, Zhong, Ling, Li, Ping, Huang, Juan, Brinkley, Bill R, Xiao-Jing, Wang

“…Mutations in the transforming growth factor beta type II receptor (TGFbetaRII) have been found in various malignant tumors, suggesting that loss of TGFbeta…”
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Aberrant cell cycle progression contributes to the early-stage accelerated carcinogenesis in transgenic epidermis expressing the dominant negative TGF betaRII by Go, Cindy, He, Wei, Zhong, Ling, Li, Ping, Huang, Juan, Brinkley, Bill R, Wang, Xiao-Jing

“…Mutations in the transforming growth factor betatype II receptor (TGFbetaRII) have been found in various malignant tumors, suggesting that loss of…”
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Dynamics of Human Replication Protein A Subunit Distribution and Partitioning in the Cell Cycle by Murti, Kuruganti G., He, Da Cheng, Brinkley, Bill R., Scott, Rebecca, Lee, Suk-Hee

“…Human replication protein A (RPA) is a three-subunit protein complex involved in DNA replication, repair, and recombination. To gain insight into the dynamics…”
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Analysis of centrosome abnormalities and angiogenesis in epidermal-targetedp53172H mutant andp53-knockout mice after chemical carcinogenesis: Evidence for a gain of function by Wang, Xiao-Jing, Greenhalgh, David A., Jiang, Aibo, He, Dacheng, Zhong, Ling, Brinkley, Bill R., Roop, Dennis R.

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