Search Results - "Brinkkoetter, Paul T"

Anaerobic Glycolysis Maintains the Glomerular Filtration Barrier Independent of Mitochondrial Metabolism and Dynamics by Brinkkoetter, Paul T., Bork, Tillmann, Salou, Sarah, Liang, Wei, Mizi, Athanasia, Özel, Cem, Koehler, Sybille, Hagmann, H. Henning, Ising, Christina, Kuczkowski, Alexander, Schnyder, Svenia, Abed, Ahmed, Schermer, Bernhard, Benzing, Thomas, Kretz, Oliver, Puelles, Victor G., Lagies, Simon, Schlimpert, Manuel, Kammerer, Bernd, Handschin, Christoph, Schell, Christoph, Huber, Tobias B.

“…The cellular responses induced by mitochondrial dysfunction remain elusive. Intrigued by the lack of almost any glomerular phenotype in patients with profound…”
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Treatment of acquired thrombotic thrombocytopenic purpura without plasma exchange in selected patients under caplacizumab by Völker, Linus A., Brinkkoetter, Paul T., Knöbl, Paul N., Krstic, Miroslav, Kaufeld, Jessica, Menne, Jan, Buxhofer‐Ausch, Veronika, Miesbach, Wolfgang

“…Background Acquired thrombotic thrombocytopenic purpura (aTTP) is a rare, life‐threatening autoimmune thrombotic microangiopathy. Current standard of care is…”
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First use of the anti‐VWF nanobody caplacizumab to treat iTTP in pregnancy by Kühne, Lucas, Völker, Linus A., Hagmann, Henning, Hägele, Holger, Osterholt, Thomas, Eichenauer, Dennis A., Thomas, Andreas, Breuer, Johanna, Grüttner, Berthold, Gottschalk, Ingo, Kann, Martin, Benzing, Thomas, Thevis, Mario, Müller, Annette M., Brinkkoetter, Paul T.

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Proteome Analysis of Isolated Podocytes Reveals Stress Responses in Glomerular Sclerosis by Koehler, Sybille, Kuczkowski, Alexander, Kuehne, Lucas, Jüngst, Christian, Hoehne, Martin, Grahammer, Florian, Eddy, Sean, Kretzler, Matthias, Beck, Bodo B, Höhfeld, Jörg, Schermer, Bernhard, Benzing, Thomas, Brinkkoetter, Paul T, Rinschen, Markus M

“…Understanding podocyte-specific responses to injury at a systems level is difficult because injury leads to podocyte loss or an increase of extracellular…”
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Simultaneous stabilization of actin cytoskeleton in multiple nephron-specific cells protects the kidney from diverse injury by Mukherjee, Kamalika, Gu, Changkyu, Collins, Agnieszka, Mettlen, Marcel, Samelko, Beata, Altintas, Mehmet M., Sudhini, Yashwanth R., Wang, Xuexiang, Bouley, Richard, Brown, Dennis, Pedro, Bradley P., Bane, Susan L., Gupta, Vineet, Brinkkoetter, Paul T., Hagmann, Henning, Reiser, Jochen, Sever, Sanja

“…Chronic kidney diseases and acute kidney injury are mechanistically distinct kidney diseases. While chronic kidney diseases are associated with podocyte…”
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Inducible rodent models of acquired podocyte diseases by Pippin, Jeffrey W, Brinkkoetter, Paul T, Cormack-Aboud, Fionnualla C, Durvasula, Raghu V, Hauser, Peter V, Kowalewska, Jolanta, Krofft, Ronald D, Logar, Christine M, Marshall, Caroline B, Ohse, Takamoto, Shankland, Stuart J

“…Glomerular diseases remain the leading cause of chronic and end-stage kidney disease. Significant advances in our understanding of human glomerular diseases…”
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Low-molecular weight heparin increases circulating sFlt-1 levels and enhances urinary elimination by Hagmann, Henning, Bossung, Verena, Belaidi, Abdel Ali, Fridman, Alexander, Karumanchi, S Ananth, Thadhani, Ravi, Schermer, Bernhard, Mallmann, Peter, Schwarz, Guenter, Benzing, Thomas, Brinkkoetter, Paul T

“…Preeclampsia is a devastating medical complication of pregnancy which leads to maternal and fetal morbidity and mortality. While the etiology of preeclampsia…”
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Light Microscopic Visualization of Podocyte Ultrastructure Demonstrates Oscillating Glomerular Contractions by Höhne, Martin, Ising, Christina, Hagmann, Henning, Völker, Linus A, Brähler, Sebastian, Schermer, Bernhard, Brinkkoetter, Paul T, Benzing, Thomas

“…Podocytes, the visceral epithelial cells of the kidney glomerulus, elaborate primary and interdigitating secondary extensions to enwrap the glomerular…”
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Plasma leakage through glomerular basement membrane ruptures triggers the proliferation of parietal epithelial cells and crescent formation in non-inflammatory glomerular injury by Ryu, Mi, Migliorini, Adriana, Miosge, Nicolai, Gross, Oliver, Shankland, Stuart, Brinkkoetter, Paul T, Hagmann, Henning, Romagnani, Paola, Liapis, Helen, Anders, Hans-Joachim

“…Glomerular crescents are most common in rapidly progressive glomerulonephritis but also occur in non‐inflammatory chronic glomerulopathies; thus, factors other…”
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Cyclin I activates Cdk5 and regulates expression of Bcl-2 and Bcl-XL in postmitotic mouse cells by Brinkkoetter, Paul T, Olivier, Paul, Wu, Jimmy S, Henderson, Scott, Krofft, Ronald D, Pippin, Jeffrey W, Hockenbery, David, Roberts, James M, Shankland, Stuart J

“…Cyclin I is an atypical cyclin because it is most abundant in postmitotic cells. We previously showed that cyclin I does not regulate proliferation, but rather…”
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Experimental Models to Study Podocyte Biology: Stock-Taking the Toolbox of Glomerular Research by Hagmann, Henning, Brinkkoetter, Paul T

“…Diseases affecting the glomeruli of the kidney, the renal filtration units, are a leading cause of chronic kidney disease and end-stage renal failure. Despite…”
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Construction of a viral T2A-peptide based knock-in mouse model for enhanced Cre recombinase activity and fluorescent labeling of podocytes by Koehler, Sybille, Brähler, Sebastian, Braun, Fabian, Hagmann, Henning, Rinschen, Markus M, Späth, Martin R, Höhne, Martin, Wunderlich, F Thomas, Schermer, Bernhard, Benzing, Thomas, Brinkkoetter, Paul T

“…Podocyte injury is a key event in glomerular disease leading to proteinuria and opening the path toward glomerular scarring. As a consequence, glomerular…”
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Paraoxonase 2 (PON2) Deficiency Reproduces Lipid Alterations of Diabetic and Inflammatory Glomerular Disease and Affects TRPC6 Signaling by Hagmann, Henning, Khayyat, Naghmeh Hassanzadeh, Oezel, Cem, Papadakis, Antonios, Kuczkowski, Alexander, Benzing, Thomas, Gulbins, Erich, Dryer, Stuart, Brinkkoetter, Paul T

“…Diabetes and inflammatory diseases are associated with an altered cellular lipid composition due to lipid peroxidation. The pathogenic potential of these lipid…”
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Live or Let Die: Is There any Cell Death in Podocytes? by Braun, Fabian, MD, Becker, Jan U., MD, Brinkkoetter, Paul T., MD

“…Summary Ultimately, the common final pathway of any glomerular disease is podocyte effacement, podocyte loss, and, eventually, glomerular scarring. There has…”
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Prohibitin-2 Depletion Unravels Extra-Mitochondrial Functions at the Kidney Filtration Barrier by Ising, Christina, Bharill, Puneet, Brinkkoetter, Sibylle, Brähler, Sebastian, Schroeter, Christina, Koehler, Sybille, Hagmann, Henning, Merkwirth, Carsten, Höhne, Martin, Müller, Roman U, Fabretti, Francesca, Schermer, Bernhard, Bloch, Wilhelm, Kerjaschki, Dontscho, Kurschat, Christine E, Benzing, Thomas, Brinkkoetter, Paul T

“…Mitochondrial fusion is essential for maintenance of mitochondrial function and requires the prohibitin ring complex subunit prohibitin-2 (PHB2) at the…”
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Capsazepine (CPZ) Inhibits TRPC6 Conductance and Is Protective in Adriamycin-Induced Nephropathy and Diabetic Glomerulopathy by Hagmann, Henning, Khayyat, Naghmeh Hassanzadeh, Matin, Mahsa, Oezel, Cem, Chen, He, Schauss, Astrid, Schell, Christoph, Benzing, Thomas, Dryer, Stuart, Brinkkoetter, Paul T

“…Reactive oxygen species (ROS), which excessively arise in diabetes and systemic inflammatory diseases, modify cellular lipids and cellular lipid composition…”
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The Atypical Cyclin-Dependent Kinase 5 (Cdk5) Guards Podocytes from Apoptosis in Glomerular Disease While Being Dispensable for Podocyte Development by Mangold, Nicole, Pippin, Jeffrey, Unnersjoe-Jess, David, Koehler, Sybille, Shankland, Stuart, Brähler, Sebastian, Schermer, Bernhard, Benzing, Thomas, Brinkkoetter, Paul T., Hagmann, Henning

“…Cyclin-dependent kinase 5 (Cdk5) is expressed in terminally differentiated cells, where it drives development, morphogenesis, and survival. Temporal and…”
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Establishment of Conditionally Immortalized Mouse Glomerular Parietal Epithelial Cells in Culture by OHSE, Takamoto, PIPPIN, Jeffrey W, VAUGHAN, Michael R, BRINKKOETTER, Paul T, KROFFT, Ronald D, SHANKLAND, Stuart J

“…Parietal epithelial cells (PEC) are major constituents of crescents in crescentic glomerulonephritis. The purpose of these studies was to establish an…”
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Contrasting consequences of podocyte insulin-like growth factor 1 receptor inhibition by Hurcombe, Jennifer A., Barrington, Fern, Marchetti, Micol, Betin, Virginie M.S., Bowen, Emily E., Lay, Abigail C., Ni, Lan, Dayalan, Lusyan, Pope, Robert J.P., Brinkkoetter, Paul T., Holzenberger, Martin, Welsh, Gavin I., Coward, Richard J.M.

“…Insulin signaling to the glomerular podocyte via the insulin receptor (IR) is critical for kidney function. In this study we show that near-complete knockout…”
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Cyclin I-Cdk5 governs survival in post-mitotic cells by Brinkkoetter, Paul T., Pippin, Jeffrey W., Shankland, Stuart J.

“…Cdk5 has long been recognized to play an important role in development, maturation and apoptosis of post-mitotic and terminally differentiated cells…”
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