Radical-regulating and antiviral properties of ascorbic acid and its derivatives

The ability of ascorbic acid and a number of its derivatives to suppress replication of Herpes simplex virus type I was investigated in human rhabdomyosarcoma cell line. In parallel, interaction of the test compounds with carbon- and oxygen-centered radicals formed on radiolysis of hydroxyl-containi...

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Bibliographic Details
Published in:	Bioorganic & medicinal chemistry letters Vol. 22; no. 7; pp. 2424 - 2427
Main Authors:	Brinkevich, Sviatoslav D., Boreko, Eugene I., Savinova, Olga V., Pavlova, Natalia I., Shadyro, Oleg I.
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier Ltd 01-04-2012 Elsevier
Subjects:	2-O-Glycosylascorbic acid Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral activity Antiviral agents Antiviral Agents - chemical synthesis Antiviral Agents - pharmacology antiviral properties Ascorbic acid Ascorbic Acid - analogs & derivatives Ascorbic Acid - chemical synthesis Ascorbic Acid - pharmacology Biological and medical sciences Carbon - chemistry Cell Line, Tumor chemistry Free Radical Scavengers - chemical synthesis Free Radical Scavengers - pharmacology free radicals herpes simplex Herpes simplex type I Herpes simplex virus Herpesvirus 1, Human - drug effects Humans Medical sciences Organic compounds Oxygen - chemistry Pharmacology. Drug treatments Radiation, Ionizing Radicals Radiolysis Reactive Oxygen Species - metabolism Reactive Oxygen Species - radiation effects Recombination Replication Rhabdomyosarcoma Steady state radiolysis viruses α-Hydroxyl-containing carbon-centered radicals Steady state radiolysis Ascorbic acid 2-O-Glycosylascorbic acid α-Hydroxyl-containing carbon-centered radicals Herpes simplex type I radicals Herpesviridae Alphaherpesvirinae Vitamin Carbon α-Hydroxyl-containing carbon-centered Virus Ascorbic acid derivatives Antiviral Radiolysis Herpesvirus hominis Pharmacokinetics
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Summary:	The ability of ascorbic acid and a number of its derivatives to suppress replication of Herpes simplex virus type I was investigated in human rhabdomyosarcoma cell line. In parallel, interaction of the test compounds with carbon- and oxygen-centered radicals formed on radiolysis of hydroxyl-containing organic compounds was studied using the steady state radiolysis method. It has been shown that 2-O-glycoside of ascorbic acid, displaying marked antiviral properties against Herpes simplex virus type I, is also capable of inhibiting fragmentation and recombination reactions of α-hydroxyl-containing carbon-centered radicals while not affecting processes involving oxygen-centered radicals.
Bibliography:	http://dx.doi.org/10.1016/j.bmcl.2012.02.022 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2012.02.022