Search Results - "Briner, Alexandra E"

Identifying and Visualizing Functional PAM Diversity across CRISPR-Cas Systems by Leenay, Ryan T., Maksimchuk, Kenneth R., Slotkowski, Rebecca A., Agrawal, Roma N., Gomaa, Ahmed A., Briner, Alexandra E., Barrangou, Rodolphe, Beisel, Chase L.

“…CRISPR-Cas adaptive immune systems in prokaryotes boast a diversity of protein families and mechanisms of action, where most systems rely on…”
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Guide RNA Functional Modules Direct Cas9 Activity and Orthogonality by Briner, Alexandra E., Donohoue, Paul D., Gomaa, Ahmed A., Selle, Kurt, Slorach, Euan M., Nye, Christopher H., Haurwitz, Rachel E., Beisel, Chase L., May, Andrew P., Barrangou, Rodolphe

“…The RNA-guided Cas9 endonuclease specifically targets and cleaves DNA in a sequence-dependent manner and has been widely used for programmable genome editing…”
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Lactobacillus buchneri Genotyping on the Basis of Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) Locus Diversity by Briner, Alexandra E, Barrangou, Rodolphe

“…Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Occurrence and Diversity of CRISPR-Cas Systems in the Genus Bifidobacterium by Briner, Alexandra E, Lugli, Gabriele Andrea, Milani, Christian, Duranti, Sabrina, Turroni, Francesca, Gueimonde, Miguel, Margolles, Abelardo, van Sinderen, Douwe, Ventura, Marco, Barrangou, Rodolphe

“…CRISPR-Cas systems constitute adaptive immune systems for antiviral defense in bacteria. We investigated the occurrence and diversity of CRISPR-Cas systems in…”
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Lactobacillus gasseri CRISPR-Cas9 characterization In Vitro reveals a flexible mode of protospacer-adjacent motif recognition by Anderson, Emily M, McClelland, Shawn, Maksimova, Elena, Strezoska, Žaklina, Basila, Megan, Briner, Alexandra E, Barrangou, Rodolphe, Smith, Anja van Brabant

“…While the CRISPR-Cas9 system from S. pyogenes is a powerful genome engineering tool, additional programmed nucleases would enable added flexibility in…”
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Deciphering and shaping bacterial diversity through CRISPR by Briner, Alexandra E, Barrangou, Rodolphe

“…Highlights • CRISPR-Cas generates diversity through phage–host genome evolution. • Cytotoxic self-targeting is highly lethal and alters bacterial population…”
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Guide RNAs: A Glimpse at the Sequences that Drive CRISPR-Cas Systems by Briner, Alexandra E, Barrangou, Rodolphe

“…CRISPR-Cas systems provide adaptive immunity in bacteria and archaea. Although there are two main classes of CRISPR-Cas systems defined by gene content,…”
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Prediction and Validation of Native and Engineered Cas9 Guide Sequences by Briner, Alexandra E, Henriksen, Emily D, Barrangou, Rodolphe

“…Cas9-based technologies rely on native elements of Type II CRISPR-Cas bacterial immune systems, including the trans-activating CRISPR RNA (tracrRNA), CRISPR…”
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Expanding the biotechnology potential of lactobacilli through comparative genomics of 213 strains and associated genera by Sun, Zhihong, Harris, Hugh M. B., McCann, Angela, Guo, Chenyi, Argimón, Silvia, Zhang, Wenyi, Yang, Xianwei, Jeffery, Ian B, Cooney, Jakki C., Kagawa, Todd F., Liu, Wenjun, Song, Yuqin, Salvetti, Elisa, Wrobel, Agnieszka, Rasinkangas, Pia, Parkhill, Julian, Rea, Mary C., O’Sullivan, Orla, Ritari, Jarmo, Douillard, François P., Paul Ross, R., Yang, Ruifu, Briner, Alexandra E., Felis, Giovanna E., de Vos, Willem M., Barrangou, Rodolphe, Klaenhammer, Todd R., Caufield, Page W., Cui, Yujun, Zhang, Heping, O’Toole, Paul W.

“…Lactobacilli are a diverse group of species that occupy diverse nutrient-rich niches associated with humans, animals, plants and food. They are used widely in…”
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Occurrence and Diversity of CRISPR-Cas Systems in the Genus Bifidobacterium: e0133661 by Briner, Alexandra E, Lugli, Gabriele Andrea, Milani, Christian, Duranti, Sabrina, Turroni, Francesca, Gueimonde, Miguel, Margolles, Abelardo, Sinderen, Douwe van, Ventura, Marco, Barrangou, Rodolphe

“…CRISPR-Cas systems constitute adaptive immune systems for antiviral defense in bacteria. We investigated the occurrence and diversity of CRISPR-Cas systems in…”
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