Search Results - "Brinen, L S"

Two Approaches to Discovering and Developing New Drugs for Chagas Disease by McKerrow, J.H, Doyle, P.S, Engel, J.C, Podust, L.M, Robertson, S.A, Ferreira, R, Saxton, T, Arkin, M, Kerr, I.D, Brinen, L.S, Craik, C.S

“…This review will focus on two general approaches carried out at the Sandler Center, University of California, San Francisco, to address the challenge of…”
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Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense by Caffrey, Conor R, Hansell, Elizabeth, Lucas, Kimberley D, Brinen, Linda S, Alvarez Hernandez, Alejandro, Cheng, Jiamning, Gwaltney, Stephen L, Roush, William R, Stierhof, York-Dieter, Bogyo, Matthew, Steverding, Dietmar, McKerrow, James H

“…Cysteine protease activity of African trypanosome parasites is a target for new chemotherapy using synthetic protease inhibitors. To support this effort and…”
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A target within the target: probing cruzain’s P1′ site to define structural determinants for the Chagas’ disease protease by Brinen, Linda S, Hansell, Elizabeth, Cheng, Jianming, Roush, William R, McKerrow, James H, Fletterick, Robert J

“…Background: Cysteine proteases of the papain superfamily are present in nearly all groups of eukaryotes and play vital roles in a wide range of biological…”
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Systematic Optimization of Expression and Refolding of the Plasmodium falciparum Cysteine Protease Falcipain-2 by Sijwali, Puran S., Brinen, Linda S., Rosenthal, Philip J.

“…The Plasmodium falciparum cysteine protease falcipain-2 is a potential new target for antimalarial chemotherapy. In order to obtain large quantities of active…”
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Chemical Investigation of the Metabolites from the Canadian Tuckahoe, Polyporus tuberaster by Ayer, William A, Sun, Mark, Browne, Lois M, Brinen, Linda S, Clardy, Jon

“…The metabolites of the Canadian tuckahoe, the sclerotium of Polyporus tuberaster, have been investigated. The ten-membered lactone tuckolide [1] was isolated,…”
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Structure of an anhydride related to a mutagenic component of drinking water, 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone by LaLonde, R. T, Perakyla, H, Ishiguro, Y, Clardy, J, Brinen, L. S

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Protease Trafficking in Two Primitive Eukaryotes Is Mediated by a Prodomain Protein Motif by Huete-Pérez, J A, Engel, J C, Brinen, L S, Mottram, J C, McKerrow, J H

“…Trypanosome protozoa, an early lineage of eukaryotic cells, have proteases homologous to mammalian lysosomal cathepsins, but the precursor proteins lack…”
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Cysteine proteinases from distinct cellular compartments are recruited to phagocytic vesicles by Entamoeba histolytica by Que, Xuchu, Brinen, Linda S, Perkins, Penny, Herdman, Scott, Hirata, Ken, Torian, Bruce E, Rubin, Harvey, McKerrow, James H, Reed, Sharon L

“…Cysteine proteinases, which are encoded by at least seven genes, play a critical role in the pathogenesis of invasive amebiasis caused by Entamoeba…”
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Can Mosquitoes Be Bitten? A New Hope for Anti-Malarial Drug Design by Brinen, Linda S., Stout, Thomas J.

“…The crystal structure of PfPK5, a cyclin-dependent kinase from Plasmodium falciparum, is the first CDK structure determined from a nonhuman source and…”
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A pentahalogenated monoterpene from the red alga Portieria hornemannii produces a novel cytotoxicity profile against a diverse panel of human tumor cell lines by Fuller, Richard W, Cardellina, John H, Kato, Yoko, Brinen, Linda S, Clardy, Jon, Snader, Kenneth M, Boyd, Michael R

“…A polyhalogenated acyclic monoterpene, 6(R)-bromo-3(S)-(bromomethyl)-7- methyl-2,3,7-trichloro-1-octene (1) was obtained as a major component of the organic…”
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Structure and stereochemistry of brianolide, a new antiinflammatory diterpenoid from the Okinawan gorgonian Briareum sp by Kobayashi, J, Cheng, J F, Nakamura, H, Ohizumi, Y, Tomotake, Y, Matsuzaki, T, Grace, K J, Jacobs, R S, Kato, Y, Brinen, L S

“…Brianolide (1), a new antiinflammatory diterpenoid of the briarein class, possessing a beta substituent at C-12 (R), has been isolated from the Okinawan…”
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New polychlorinated amino acid derivatives from the marine sponge Dysidea herbacea by Unson, Mia D, Rose, Charles B, Faulkner, D. John, Brinen, Linda S, Steiner, Jorge Rios, Clardy, Jon

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Pyrrolosporin A, a new antitumor antibiotic from Micromonospora sp. C39217-R109-7. II. Isolation, physico-chemical properties, spectroscopic study and X-ray analysis by Schroeder, D R, Colson, K L, Klohr, S E, Lee, M S, Matson, J A, Brinen, L S, Clardy, J

“…Pyrrolosporin A (1) is a new macrolide antitumor antibiotic possessing an unusual spiro-alpha-acyltetronic acid moiety. The antibiotic was isolated from the…”
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X-ray Structures of a Designed Binding Site in Trypsin Show Metal-Dependent Geometry by Brinen, Linda S, Willett, W. Scott, Craik, Charles S, Fletterick, Robert J

“…The three-dimensional structures of complexes of trypsin N143H, E151H bound to ecotin A86H are determined at 2.0 Å resolution via X-ray crystallography in the…”
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Delocalizing Trypsin Specificity with Metal Activation by Willett, W. Scott, Brinen, Linda S, Fletterick, Robert J, Craik, Charles S

“…Recognition for proteolysis by trypsin depends almost exclusively on tight binding of arginine or lysine side chains by the primary substrate specificity…”
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New Chlorophyll-A-Related Compounds Isolated as Antioxidants from Marine Bivalves by Watanabe, Naoharu, Yamamoto, Ken'ichi, Ihshikawa, Hiromi, Yagi, Akihito, Sakata, Kanzo, Brinen, Linda S, Clardy, Jon

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Homology Modeling of Entamoeba histolytica Cysteine Proteinases Reveals the Basis for Cathepsin L-Like Structure with Cathepsin B-Like Specificity by Brinen, Linda S, Que, Xuchu, McKerrow, James H, Reed, Sharon L

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Structure of efrapeptins from the fungus Tolypocladium niveum: peptide inhibitors of mitochondrial ATPase by Gupta, Sandeep, Krasnoff, Stuart B, Roberts, Donald W, Renwick, J. A. A, Brinen, Linda S, Clardy, Jon

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Structures of the efrapeptins: potent inhibitors of mitochondrial ATPase from the fungus Tolypocladium niveum by Gupta, Sandeep, Krasnoff, Stuart B., Roberts, Donald W., Renwick, J. A. A., Brinen, Linda S., Clardy, Jon

“…The efrapeptins are a series of novel peptides produced by the entomopathogenic fungus Tolypocladium niveum . In addition to their insect toxicity, they…”
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Absolute Stereochemistry of (+)-Gigantecin from Annona coriacea (Annonaceae) by Yu, Jing-Guang, Hu, Xiufeng E, Ho, David K, Bean, Mark F, Stephens, Ralph E, Cassady, John M, Brinen, Linda S, Clardy, Jon

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