Search Results - "Brindley, Melinda"

Attenuated replication and pathogenicity of SARS-CoV-2 B.1.1.529 Omicron by Shuai, Huiping, Chan, Jasper Fuk-Woo, Hu, Bingjie, Chai, Yue, Yuen, Terrence Tsz-Tai, Yin, Feifei, Huang, Xiner, Yoon, Chaemin, Hu, Jing-Chu, Liu, Huan, Shi, Jialu, Liu, Yuanchen, Zhu, Tianrenzheng, Zhang, Jinjin, Hou, Yuxin, Wang, Yixin, Lu, Lu, Cai, Jian-Piao, Zhang, Anna Jinxia, Zhou, Jie, Yuan, Shuofeng, Brindley, Melinda A., Zhang, Bao-Zhong, Huang, Jian-Dong, To, Kelvin Kai-Wang, Yuen, Kwok-Yung, Chu, Hin

“…The Omicron (B.1.1.529) variant of SARS-CoV-2 emerged in November 2021 and is rapidly spreading among the human population 1 . Although recent reports reveal…”
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Virus-Receptor Interactions of Glycosylated SARS-CoV-2 Spike and Human ACE2 Receptor by Zhao, Peng, Praissman, Jeremy L., Grant, Oliver C., Cai, Yongfei, Xiao, Tianshu, Rosenbalm, Katelyn E., Aoki, Kazuhiro, Kellman, Benjamin P., Bridger, Robert, Barouch, Dan H., Brindley, Melinda A., Lewis, Nathan E., Tiemeyer, Michael, Chen, Bing, Woods, Robert J., Wells, Lance

“…The SARS-CoV-2 betacoronavirus uses its highly glycosylated trimeric Spike protein to bind to the cell surface receptor angiotensin converting enzyme 2 (ACE2)…”
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Zika virus infection disrupts neurovascular development and results in postnatal microcephaly with brain damage by Shao, Qiang, Herrlinger, Stephanie, Yang, Si-Lu, Lai, Fan, Moore, Julie M, Brindley, Melinda A, Chen, Jian-Fu

“…Zika virus (ZIKV) infection of pregnant women can result in fetal brain abnormalities. It has been established that ZIKV disrupts neural progenitor cells…”
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Fusogenic structural changes in arenavirus glycoproteins are associated with viroporin activity by Zhang, You, York, Joanne, Brindley, Melinda A, Nunberg, Jack H, Melikyan, Gregory B

“…Many enveloped viruses enter host cells by fusing with acidic endosomes. The fusion activity of multiple viral envelope glycoproteins does not generally affect…”
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Temperature drives Zika virus transmission: evidence from empirical and mathematical models by Tesla, Blanka, Demakovsky, Leah R, Mordecai, Erin A, Ryan, Sadie J, Bonds, Matthew H, Ngonghala, Calistus N, Brindley, Melinda A, Murdock, Courtney C

“…Temperature is a strong driver of vector-borne disease transmission. Yet, for emerging arboviruses we lack fundamental knowledge on the relationship between…”
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Scrambled or flipped: 5 facts about how cellular phosphatidylserine localization can mediate viral replication by Acciani, Marissa Danielle, Brindley, Melinda Ann

“…PtdSer, phosphatidylserine; TMEM16F, transmembrane protein 16F; XKR, XK related. https://doi.org/10.1371/journal.ppat.1010352.g001 Cells expose PtdSer during…”
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The African Zika virus MR-766 is more virulent and causes more severe brain damage than current Asian lineage and dengue virus by Shao, Qiang, Herrlinger, Stephanie, Zhu, Ya-Nan, Yang, Mei, Goodfellow, Forrest, Stice, Steven L, Qi, Xiao-Peng, Brindley, Melinda A, Chen, Jian-Fu

“…The Zika virus (ZIKV) has two lineages, Asian and African, and their impact on developing brains has not been compared. Dengue virus (DENV) is a close family…”
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Cell surface glycan engineering reveals that matriglycan alone can recapitulate dystroglycan binding and function by Sheikh, M. Osman, Capicciotti, Chantelle J., Liu, Lin, Praissman, Jeremy, Ding, Dahai, Mead, Daniel G., Brindley, Melinda A., Willer, Tobias, Campbell, Kevin P., Moremen, Kelley W., Wells, Lance, Boons, Geert-Jan

“…α-Dystroglycan (α-DG) is uniquely modified on O -mannose sites by a repeating disaccharide (-Xylα1,3-GlcAβ1,3-) n termed matriglycan, which is a receptor for…”
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Structural and mechanistic studies of measles virus illuminate paramyxovirus entry by Plemper, Richard K, Brindley, Melinda A, Iorio, Ronald M

“…Measles virus (MeV), a member of the paramyxovirus family of enveloped RNA viruses and one of the most infectious viral pathogens identified, accounts for…”
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Temperate Conditions Limit Zika Virus Genome Replication by Tesla, Blanka, Powers, Jenna S, Barnes, Yvonne, Lakhani, Shamil, Acciani, Marissa D, Brindley, Melinda A

“…Zika virus is a mosquito-borne flavivirus known to cause severe birth defects and neuroimmunological disorders. We have previously demonstrated that mosquito…”
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Promotion of virus assembly and organization by the measles virus matrix protein by Ke, Zunlong, Strauss, Joshua D., Hampton, Cheri M., Brindley, Melinda A., Dillard, Rebecca S., Leon, Fredrick, Lamb, Kristen M., Plemper, Richard K., Wright, Elizabeth R.

“…Measles virus (MeV) remains a major human pathogen, but there are presently no licensed antivirals to treat MeV or other paramyxoviruses. Here, we use…”
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Estimating the effects of variation in viremia on mosquito susceptibility, infectiousness, and R0 of Zika in Aedes aegypti by Tesla, Blanka, Demakovsky, Leah R, Packiam, Hannah S, Mordecai, Erin A, Rodríguez, Américo D, Bonds, Matthew H, Brindley, Melinda A, Murdock, Courtney C

“…Zika virus (ZIKV) is an arbovirus primarily transmitted by Aedes mosquitoes. Like most viral infections, ZIKV viremia varies over several orders of magnitude,…”
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SARS-CoV-2 Spike Alterations Enhance Pseudoparticle Titers and Replication-Competent VSV-SARS-CoV-2 Virus by Havranek, Katherine Elizabeth, Jimenez, Ariana R, Acciani, Marissa Danielle, Lay Mendoza, Maria Fernanda, Reyes Ballista, Judith Mary, Diaz, Darren Austin, Brindley, Melinda Ann

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the most recent global pandemic that has caused more than a million…”
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Modulation of immunosuppressant drug treatment to improve SARS-CoV-2 vaccine efficacy in mice by Paschall, Amy V., Ozdilek, Ahmet, Briner, Sydney L., Brindley, Melinda A., Avci, Fikri Y.

“…•Immunosuppressants impair antibody levels against SARS-CoV-2 spike protein.•Cyclophosphamide, methotrexate, and methylprednisolone impair virus…”
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Triggering the measles virus membrane fusion machinery by Brindley, Melinda A, Takeda, Makoto, Plattet, Philippe, Plemper, Richard K

“…Paramyxoviruses contain glycoprotein fusion machineries that mediate membrane merger for infection. The molecular framework and mechanistic principles…”
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Strain-Dependent Consequences of Zika Virus Infection and Differential Impact on Neural Development by Goodfellow, Forrest T, Willard, Katherine A, Wu, Xian, Scoville, Shelley, Stice, Steven L, Brindley, Melinda A

“…Maternal infection with Zika virus (ZIKV) during pregnancy can result in neonatal abnormalities, including neurological dysfunction and microcephaly…”
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A Stabilized Headless Measles Virus Attachment Protein Stalk Efficiently Triggers Membrane Fusion by Brindley, Melinda A, Suter, Rolf, Schestak, Isabel, Kiss, Gabriella, Wright, Elizabeth R, Plemper, Richard K

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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mSphere of Influence: Apoptotic Mimicry and Virus Entry by Brindley, Melinda A

“…Melinda A. Brindley works in the field of virology with specific interests in understanding how viruses enter cells. In this mSphere of Influence article, she…”
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Zika Virus Induced Mortality and Microcephaly in Chicken Embryos by Goodfellow, Forrest T, Tesla, Blanka, Simchick, Gregory, Zhao, Qun, Hodge, Thomas, Brindley, Melinda A, Stice, Steven L

“…The explosive spread of the Zika virus (ZIKV) through South and Central America has been linked to an increase in congenital birth defects, specifically…”
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Zika Virus Exhibits Lineage-Specific Phenotypes in Cell Culture, in Aedes aegypti Mosquitoes, and in an Embryo Model by Willard, Katherine A, Demakovsky, Leah, Tesla, Blanka, Goodfellow, Forrest T, Stice, Steven L, Murdock, Courtney C, Brindley, Melinda A

“…Zika virus (ZIKV) has quietly circulated in Africa and Southeast Asia for the past 65 years. However, the recent ZIKV epidemic in the Americas propelled this…”
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