Search Results - "Brindley, D N"

Autotaxin protects MCF-7 breast cancer and MDA-MB-435 melanoma cells against Taxol-induced apoptosis by Samadi, N, Gaetano, C, Goping, I S, Brindley, D N

“…Autotaxin (ATX) promotes cancer cell survival, growth, migration, invasion and metastasis. ATX converts extracellular lysophosphatidylcholine (LPC) into…”
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Review: Novel insights into the regulation of vascular tone by sphingosine 1-phosphate by Kerage, D, Brindley, D.N, Hemmings, D.G

“…Abstract Endothelial dysfunction leading to increased vascular tone is implicated in the pathogenesis of cardiovascular disease, hypertension and…”
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Platelet-released phospholipids link haemostasis and angiogenesis by ENGLISH, Denis, GARCIA, Joe G. N, BRINDLEY, D. N

“…Considerable attention has focused on identifying mediators of neovascularization at sites of growth and abnormal tissue development. By contrast, mediators of…”
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Role of glucocorticoids and fatty acids in the impairment of lipid metabolism observed in the metabolic syndrome by Brindley, D N

“…The metabolic syndrome is discussed in terms of insulin resistance linked to an increased regulation of metabolism by cortisol and fatty acids. This change in…”
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Cell-permeable ceramides inhibit the stimulation of DNA synthesis and phospholipase D activity by phosphatidate and lysophosphatidate in rat fibroblasts by Gomez-Muñoz, A, Martin, A, O'Brien, L, Brindley, D N

“…The interactions of ceramides with phosphatidate and lysophosphatidate in the regulation of signal transduction in rat fibroblasts were examined. C2- and…”
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Effects of cell-permeable ceramides and tumor necrosis factor-alpha on insulin signaling and glucose uptake in 3T3-L1 adipocytes by Wang, C. N., O'Brien, L., Brindley, D. N.

“…Effects of cell-permeable ceramides and tumor necrosis factor-alpha on insulin signaling and glucose uptake in 3T3-L1 adipocytes. C N Wang , L O'Brien and D N…”
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Tumor necrosis factor-alpha induces stress fiber formation through ceramide production: role of sphingosine kinase by Hanna, A N, Berthiaume, L G, Kikuchi, Y, Begg, D, Bourgoin, S, Brindley, D N

“…Tumor necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine that activates several signaling cascades. We determined the extent to which ceramide is…”
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Cell-permeable ceramides increase basal glucose incorporation into triacylglycerols but decrease the stimulation by insulin in 3T3-L1 adipocytes by Mei, J, Wang, C.N, O'Brien, L, Brindley, D.N

“…OBJECTIVE: To investigate mechanisms for the regulation of glucose incorporation into triacylgycerols in adipocytes by ceramides, which mediate some actions of…”
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Developmental changes in adipose and muscle lipoprotein lipase activity in the atherosclerosis-prone JCR:LA-corpulent rat by Mantha, L, Russell, J.C, Brindley, D.N, Deshaies, Y

“…OBJECTIVE: To characterize the developmental changes in adipose and muscle lipoprotein lipase (LPL) activity in the atherosclerosis-prone JCR:LA-corpulent rat,…”
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Plasma membrane fractions from rat liver contain a phosphatidate phosphohydrolase distinct from that in the endoplasmic reticulum and cytosol by Jamal, Z, Martin, A, Gomez-Munoz, A, Brindley, D N

“…Assays for two distinct phosphatidate phosphohydrolase activities were established based upon a differential inhibition by N-ethylmaleimide (NEM). The activity…”
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Short-chain ceramide-1-phosphates are novel stimulators of DNA synthesis and cell division: antagonism by cell-permeable ceramides by Gomez-Muñoz, A, Duffy, P A, Martin, A, O'Brien, L, Byun, H S, Bittman, R, Brindley, D N

“…Ceramide and ceramide-1-phosphate are sphingolipid analogues of diacylglycerol and phosphatidate, respectively, and they are putative second messengers of…”
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Possible connections between stress, diabetes, obesity, hypertension and altered lipoprotein metabolism that may result in atherosclerosis by Brindley, D N, Rolland, Y

“…This review has discussed some metabolic and endocrine changes that can be associated with a stress type of metabolism, diabetes, obesity, hypertension,…”
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Improvement of insulin sensitivity and cardiovascular outcomes in the JCR:LA-cp rat by D-fenfluramine by RUSSELL, J. C, DOLPHIN, P. J, GRAHAM, S. E, AMY, R. M, BRINDLEY, D. N

“…Obese male rats of the JCR:LA-cp strain are insulin resistant, normoglycaemic, hypertriglyceridaemic, and atherosclerosis-prone. Such rats were treated from 6…”
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Ceramide Inhibition of Mammalian Phospholipase D1 and D2 Activities Is Antagonized by Phosphatidylinositol 4,5-Bisphosphate by Singh, Indrapal N, Stromberg, Lana M, Bourgoin, Sylvain G, Sciorra, Vicki A, Morris, Andrew J, Brindley, David N

“…Ceramides inhibit phospholipase D (PLD) activity in several mammalian cell types. These effects have been related to preventing activation by ARF1, RhoA, and…”
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Decreased activities of phosphatidate phosphohydrolase and phospholipase D in ras and tyrosine kinase (fps) transformed fibroblasts by MARTIN, A, GOMEZ-MUNOZ, A, WAGGONER, D. W, STONE, J. C, BRINDLEY, D. N

“…The activity of N-ethylmaleimide-insensitive phosphatidate phosphohydrolase (PAP-2) was characterized in control, ras-transformed, and tyrosine kinase-(fps)…”
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Neuroendocrine regulation and obesity by Brindley, D N

“…The combined syndrome of android (upper body) obesity, diabetes, hyperlipidaemia and hypertension is discussed in terms of a deranged endocrine regulation of…”
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Stress and lipoprotein metabolism: modulators and mechanisms by Brindley, D N, McCann, B S, Niaura, R, Stoney, C M, Suarez, E C

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Mammalian Lipid Phosphate Phosphohydrolases by Brindley, David N., Waggoner, David W.

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Increased concentrations of phosphatidate, diacylglycerol and ceramide in ras- and tyrosine kinase (fps)-transformed fibroblasts by MARTIN, A, DUFFY, P. A, LIOSSIS, C, GOMEZ-MUNOZ, A, O'BRIEN, L, STONE, J. C, BRINDLEY, D. N

“…Concentrations of the bioactive lipids, phosphatidate and diacylglycerol, increased with time in culture in ras- and tyrosine kinase (fps)-transformed…”
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Sphingosine 1‐phosphate released from platelets during clotting accounts for the potent endothelial cell chemotactic activity of blood serum and provides a novel link between hemostasis and angiogenesis by English, Denis, Welch, Zachary, Kovala, A. Thomas, Harvey, Kevin, Volpert, Olga V., Brindley, David N., Garcia, Joe G. N.

“…ABSTRACT Recent studies have identified factors responsible for angiogenesis within developing tumors, but mediators of vessel formation at sites of trauma,…”
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