Search Results - "Brindle, P"

Accuracy and impact of risk assessment in the primary prevention of cardiovascular disease: a systematic review by Brindle, P, Beswick, A, Fahey, T, Ebrahim, S

“…Objective: To determine the accuracy of assessing cardiovascular disease (CVD) risk in the primary prevention of CVD and its impact on clinical outcomes…”
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Adding social deprivation and family history to cardiovascular risk assessment: the ASSIGN score from the Scottish Heart Health Extended Cohort (SHHEC) by Woodward, Mark, Brindle, Peter, Tunstall-Pedoe, Hugh

“…Objective: To improve equity in cardiovascular disease prevention by developing a cardiovascular risk score including social deprivation and family history…”
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Predictive accuracy of the Framingham coronary risk score in British men:prospective cohort study by Brindle, Peter, Jonathan, Emberson, Lampe, Fiona, Walker, Mary, Whincup, Peter, Fahey, Tom, Ebrahim, Shah

“…Abstract Objective To establish the predictive accuracy of the Framingham risk score for coronary heart disease in a representative British population. Design…”
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In vitro evolution predicts emerging SARS-CoV-2 mutations with high affinity for ACE2 and cross-species binding by Bate, Neil, Savva, Christos G, Moody, Peter C E, Brown, Edward A, Evans, Sian E, Ball, Jonathan K, Schwabe, John W R, Sale, Julian E, Brindle, Nicholas P J

“…Emerging SARS-CoV-2 variants are creating major challenges in the ongoing COVID-19 pandemic. Being able to predict mutations that could arise in SARS-CoV-2…”
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Performance of the QRISK cardiovascular risk prediction algorithm in an independent UK sample of patients from general practice: a validation study by Hippisley-Cox, J, Coupland, C, Vinogradova, Y, Robson, J, Brindle, P

“…To assess the performance of the QRISK score for predicting cardiovascular disease (CVD) in an independent UK sample from general practice and compare with the…”
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Derivation, validation, and evaluation of a new QRISK model to estimate lifetime risk of cardiovascular disease: cohort study using QResearch database by Hippisley-Cox, Julia, Coupland, Carol, Robson, John, Brindle, Peter

“…Objective To develop, validate, and evaluate a new QRISK model to estimate lifetime risk of cardiovascular disease.Design Prospective cohort study with…”
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Signaling and Functions of Angiopoietin-1 in Vascular Protection by Brindle, Nicholas P.J, Saharinen, Pipsa, Alitalo, Kari

“…Angiopoietin-1 (Ang1) has powerful vascular protective effectssuppressing plasma leakage, inhibiting vascular inflammation, and preventing endothelial death…”
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Physical Properties of Whey Protein-Hydroxypropylmethylcellulose Blend Edible Films by Brindle, L.P., Krochta, J.M.

“…The formations of glycerol (Gly)‐plasticized whey protein isolate (WPI)–hydroxypropylmethylcellulose (HPMC) films, blended using different combinations and at…”
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Regulation of Angiopoietin Signalling by Soluble Tie2 Ectodomain and Engineered Ligand Trap by Alawo, Deborah O. A., Tahir, Tariq A., Fischer, Marlies, Bates, Declan G., Amirova, Svetlana R., Brindle, Nicholas P. J.

“…Angiopoietin-1 (Angpt1) is a glycoprotein ligand important for maintaining the vascular system. It signals via a receptor tyrosine kinase expressed on the…”
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Carotid plaque instability and ischemic symptoms are linked to immaturity of microvessels within plaques by Dunmore, Benjamin J., PhD, McCarthy, Mark J., PhD, FRCS, Naylor, A. Ross, MD, FRCS, Brindle, Nicholas P.J., PhD

“…Background Instability and rupture of carotid atherosclerotic plaques leads to thromboemboli and ischemic symptoms. Angiogenesis occurs within atherosclerotic…”
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Predicting risk of type 2 diabetes in England and Wales: prospective derivation and validation of QDScore by Hippisley-Cox, Julia, Coupland, Carol, Robson, John, Sheikh, Aziz, Brindle, Peter

“…Objective To develop and validate a new diabetes risk algorithm (the QDScore) for estimating 10 year risk of acquiring diagnosed type 2 diabetes over a 10 year…”
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The molecular balance between receptor tyrosine kinases Tie1 and Tie2 is dynamically controlled by VEGF and TNFα and regulates angiopoietin signalling by Singh, Harprit, Hansen, Tania M, Patel, Nisha, Brindle, Nicholas P J

“…Angiopoietin-1 (Ang1) signals via the receptor tyrosine kinase Tie2 which exists in complex with the related protein Tie1 at the endothelial cell surface. Tie1…”
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Regulated Proteolytic Processing of Tie1 Modulates Ligand Responsiveness of the Receptor-tyrosine Kinase Tie2 by Marron, Marie B., Singh, Harprit, Tahir, Tariq A., Kavumkal, Jais, Kim, Hak-Zoo, Koh, Gou Young, Brindle, Nicholas P.J.

“…Regulated ectodomain shedding followed by intramembrane proteolysis has recently been recognized as important in cell signaling and for degradation of several…”
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Primary prevention of cardiovascular disease: a web-based risk score for seven British black and minority ethnic groups by Brindle, P, May, M, Gill, P, Cappuccio, F, D’Agostino, R, Fischbacher, C, Ebrahim, S

“…Objective: To recalibrate an existing Framingham risk score to produce a web-based tool for estimating the 10-year risk of coronary heart disease (CHD) and…”
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Cardiovascular disease risk assessment in older women: can we improve on Framingham? British Women’s Heart and Health prospective cohort study by May, M, Lawlor, D A, Brindle, P, Patel, R, Ebrahim, S

“…Objectives: To develop a cardiovascular risk assessment tool that is feasible and easy to use in primary care (general practice (GP) model). Design:…”
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Design and preliminary recruitment results of the Cluster randomised triAl of PSA testing for Prostate cancer (CAP) by Turner, E L, Metcalfe, C, Donovan, J L, Noble, S, Sterne, J A C, Lane, J A, Avery, K N, Down, L, Walsh, E, Davis, M, Ben-Shlomo, Y, Oliver, S E, Evans, S, Brindle, P, Williams, N J, Hughes, L J, Hill, E M, Davies, C, Ng, S Y, Neal, D E, Hamdy, F C, Martin, R M

“…Background: Screening for prostate cancer continues to generate controversy because of concerns about over-diagnosis and unnecessary treatment. We describe the…”
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Histone Deacetylase Inhibitors Enhance Memory and Synaptic Plasticity via CREB: CBP-Dependent Transcriptional Activation by Vecsey, Christopher G, Hawk, Joshua D, Lattal, K. Matthew, Stein, Joel M, Fabian, Sara A, Attner, Michelle A, Cabrera, Sara M, McDonough, Conor B, Brindle, Paul K, Abel, Ted, Wood, Marcelo A

“…Histone deacetylase (HDAC) inhibitors increase histone acetylation and enhance both memory and synaptic plasticity. The current model for the action of HDAC…”
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Activation of cAMP and mitogen responsive genes relies on a common nuclear factor by Arias, J, Alberts, A. S, Brindle, P, Claret, F. X, Smeal, T, Karin, M, Feramisco, J, Montminy, M

“…A number of signalling pathways stimulate transcription of target genes through nuclear factors whose activities are primarily regulated by phosphorylation…”
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Intrinsic differences in the mechanisms of Tie2 binding to angiopoietins exploited by directed evolution to create an Ang2-selective ligand trap by Bate, Neil, Lodge, James, Brindle, Nicholas P.J.

“…Angiopoietins Ang1 and Ang2 are secreted ligands for the endothelial receptor tyrosine kinase Tie2 essential for vascular development and maintenance. Ang1…”
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Directed Evolution of an Angiopoietin-2 Ligand Trap by Somatic Hypermutation and Cell Surface Display by Brindle, Nicholas P.J., Sale, Julian E., Arakawa, Hiroshi, Buerstedde, Jean-Marie, Nuamchit, Teonchit, Sharma, Shikha, Steele, Kathryn H.

“…Tie2 is a receptor tyrosine kinase that is essential for the development and maintenance of blood vessels through binding the soluble ligands angiopoietin 1…”
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