Search Results - "Brindle, Nicholas P. J."

In vitro evolution predicts emerging SARS-CoV-2 mutations with high affinity for ACE2 and cross-species binding by Bate, Neil, Savva, Christos G, Moody, Peter C E, Brown, Edward A, Evans, Sian E, Ball, Jonathan K, Schwabe, John W R, Sale, Julian E, Brindle, Nicholas P J

“…Emerging SARS-CoV-2 variants are creating major challenges in the ongoing COVID-19 pandemic. Being able to predict mutations that could arise in SARS-CoV-2…”
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Regulated Proteolytic Processing of Tie1 Modulates Ligand Responsiveness of the Receptor-tyrosine Kinase Tie2 by Marron, Marie B., Singh, Harprit, Tahir, Tariq A., Kavumkal, Jais, Kim, Hak-Zoo, Koh, Gou Young, Brindle, Nicholas P.J.

“…Regulated ectodomain shedding followed by intramembrane proteolysis has recently been recognized as important in cell signaling and for degradation of several…”
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Signaling and Functions of Angiopoietin-1 in Vascular Protection by Brindle, Nicholas P.J, Saharinen, Pipsa, Alitalo, Kari

“…Angiopoietin-1 (Ang1) has powerful vascular protective effectssuppressing plasma leakage, inhibiting vascular inflammation, and preventing endothelial death…”
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Regulation of Angiopoietin Signalling by Soluble Tie2 Ectodomain and Engineered Ligand Trap by Alawo, Deborah O. A., Tahir, Tariq A., Fischer, Marlies, Bates, Declan G., Amirova, Svetlana R., Brindle, Nicholas P. J.

“…Angiopoietin-1 (Angpt1) is a glycoprotein ligand important for maintaining the vascular system. It signals via a receptor tyrosine kinase expressed on the…”
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Carotid plaque instability and ischemic symptoms are linked to immaturity of microvessels within plaques by Dunmore, Benjamin J., PhD, McCarthy, Mark J., PhD, FRCS, Naylor, A. Ross, MD, FRCS, Brindle, Nicholas P.J., PhD

“…Background Instability and rupture of carotid atherosclerotic plaques leads to thromboemboli and ischemic symptoms. Angiogenesis occurs within atherosclerotic…”
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The molecular balance between receptor tyrosine kinases Tie1 and Tie2 is dynamically controlled by VEGF and TNFα and regulates angiopoietin signalling by Singh, Harprit, Hansen, Tania M, Patel, Nisha, Brindle, Nicholas P J

“…Angiopoietin-1 (Ang1) signals via the receptor tyrosine kinase Tie2 which exists in complex with the related protein Tie1 at the endothelial cell surface. Tie1…”
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Functional analysis of a mutant form of the receptor tyrosine kinase Tie2 causing venous malformations by MORRIS, Paul N, DUNMORE, Benjamin J, TADROS, Amir, MARCHUK, Douglas A, DARLAND, Diane C, D'AMORE, Patricia A, BRINDLE, Nicholas P. J

“…Tie2 is expressed predominantly in endothelial cells and is required for blood vessel formation and maintenance. A missense mutation resulting in an R to W…”
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Directed Evolution of an Angiopoietin-2 Ligand Trap by Somatic Hypermutation and Cell Surface Display by Brindle, Nicholas P.J., Sale, Julian E., Arakawa, Hiroshi, Buerstedde, Jean-Marie, Nuamchit, Teonchit, Sharma, Shikha, Steele, Kathryn H.

“…Tie2 is a receptor tyrosine kinase that is essential for the development and maintenance of blood vessels through binding the soluble ligands angiopoietin 1…”
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Intrinsic differences in the mechanisms of Tie2 binding to angiopoietins exploited by directed evolution to create an Ang2-selective ligand trap by Bate, Neil, Lodge, James, Brindle, Nicholas P.J.

“…Angiopoietins Ang1 and Ang2 are secreted ligands for the endothelial receptor tyrosine kinase Tie2 essential for vascular development and maintenance. Ang1…”
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ABIN-2 protects endothelial cells from death and has a role in the antiapoptotic effect of angiopoietin-1 by Tadros, Amir, Hughes, David P., Dunmore, Benjamin J., Brindle, Nicholas P.J.

“…A20 binding inhibitor of NF-κB activation-2, ABIN-2, is a newly identified intracellular protein that interacts with the zinc finger protein A20. ABIN-2…”
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The RNA binding protein hnRNP-K mediates post-transcriptional regulation of uncoupling protein-2 by angiopoietin-1 by Tahir, Tariq A., Singh, Harprit, Brindle, Nicholas P.J.

“…Angiopoietin-1 (Ang1) is a ligand for the receptor tyrosine kinase Tie2 and has key roles in the development of the vascular system and vascular protection. In…”
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Effects of angiopoietins-1 and -2 on the receptor tyrosine kinase Tie2 are differentially regulated at the endothelial cell surface by Hansen, Tania M., Singh, Harprit, Tahir, Tariq A., Brindle, Nicholas P.J.

“…Angiopoietin-1 (Ang1) and Ang2 are ligands for the receptor tyrosine kinase Tie2. Structural data suggest that the two ligands bind Tie2 similarly. However, in…”
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Vasodilator-Stimulated Phosphoprotein Is Involved in Stress-Fiber and Membrane Ruffle Formation in Endothelial Cells by Price, Caroline J, Brindle, Nicholas P. J

“…Vasodilator-stimulated phosphoprotein (VASP) is highly expressed in vascular endothelial cells, where it has been implicated in cellular reorganization during…”
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Molecular control of angiopoietin signalling by Singh, Harprit, Tahir, Tariq A, Alawo, Deborah O A, Issa, Eyad, Brindle, Nicholas P J

“…The angiopoietins act through the endothelial receptor tyrosine kinase Tie2 to regulate vessel maturation in angiogenesis and control quiescence and stability…”
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Studies on the morphology and spreading of human endothelial cells define key inter- and intramolecular interactions for talin1 by Kopp, Petra M., Bate, Neil, Hansen, Tania M., Brindle, Nicholas P.J., Praekelt, Uta, Debrand, Emmanuel, Coleman, Stacey, Mazzeo, Daniela, Goult, Benjamin T., Gingras, Alexandre R., Pritchard, Catrin A., Critchley, David R., Monkley, Susan J.

“…Talin binds to and activates integrins and is thought to couple them to cytoskeletal actin. However, functional studies on talin have been restricted by the…”
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Vascular endothelial growth factor and angiopoietins in neurovascular regeneration and protection following stroke by Hansen, Tania M, Moss, Andrew J, Brindle, Nicholas P J

“…Vascular endothelial growth factor (VEGF) and angiopoietin-1 (Ang1) were originally identified as endothelial-specific ligands regulating key functions of the…”
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Development of an Orthogonal Tie2 Ligand Resistant to Inhibition by Ang2 by Issa, Eyad, Moss, Andrew J, Fischer, Marlies, Kang, Mandeep, Ahmed, Sultan, Farah, Hussein, Bate, Neil, Giakomidi, Despoina, Brindle, Nicholas PJ

“…Angiopoietin-1 (Ang1) is a vascular protective ligand that acts through the receptor tyrosine kinase Tie2 to enhance endothelial survival and quiescence. In…”
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Vascular endothelial growth factor activates the Tie family of receptor tyrosine kinases by Singh, Harprit, Milner, Christopher S., Aguilar Hernandez, Maria M., Patel, Nisha, Brindle, Nicholas P.J.

“…The ability of cells to respond appropriately to changes in their environment requires integration and cross-talk between relevant signalling pathways. The…”
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High glucose and elevated fatty acids suppress signaling by the endothelium protective ligand angiopoietin-1 by Singh, Harprit, Brindle, Nicholas P.J., Zammit, Victor A.

“…Pre-diabetes is characterized by hyperglycemia and dyslipidemia; it is associated with increased cardiovascular disease and endothelial dysfunction…”
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Rational design and protein engineering of growth factors for regenerative medicine and tissue engineering by Moss, Andrew J, Sharma, Shikha, Brindle, Nicholas P J

“…Growth factors provide key instructive cues for tissue formation and repair. However, many natural growth factors are limited in their usefulness for tissue…”
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