Search Results - "Brin, Mitchell"

Entering the 4th decade of Botox (onabotulinumtoxinA): A narrative review of its development and impact on patients and medicine by Brin, Mitchell F.

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Botox (onabotulinumtoxinA) mechanism of action by Brin, Mitchell F., Burstein, Rami

“…Studies in the 1920s found that botulinum neurotoxin type A (BoNT/A) inhibited the activity of motor and parasympathetic nerve endings, confirmed several…”
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Mechanism of Action of OnabotulinumtoxinA in Chronic Migraine: A Narrative Review by Burstein, Rami, Blumenfeld, Andrew M., Silberstein, Stephen D., Manack Adams, Aubrey, Brin, Mitchell F.

“…Objective To review the literature on the mechanism of action of onabotulinumtoxinA in chronic migraine. Background OnabotulinumtoxinA is a chronic migraine…”
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Treatment of cervical dystonia with Botox (onabotulinumtoxinA): Development, insights, and impact by Jankovic, Joseph, Tsui, Joseph, Brin, Mitchell F.

“…Cervical dystonia (CD), the most common focal dystonia encountered in neurologic practice, is a chronic disorder in which the muscles of the neck involuntarily…”
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The pluripotential evolution and journey of Botox (onabotulinumtoxinA) by Brin, Mitchell F., Blitzer, Andrew

“…Clinical use of onabotulinumtoxinA evolved based on strategic, hypothesis-driven applications, as well as serendipitous observations by physicians and…”
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Chronic Migraine: An Update on Physiology, Imaging, and the Mechanism of Action of Two Available Pharmacologic Therapies by Aurora, Sheena K., Brin, Mitchell F.

“…Several lines of research support the hypothesis that migraine is a spectrum of illness, with clinical symptoms that vary along a continuum from episodic…”
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Botulinum toxin type E associated with reduced itch and pain during wound healing and acute scar formation following excision and linear repair on the forehead: A randomized controlled trial by Alam, Murad, Vitarella, Domenico, Ahmad, Wajdie, Abushakra, Susan, Mao, Cheri, Brin, Mitchell F.

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Selective inhibition of meningeal nociceptors by botulinum neurotoxin type A: therapeutic implications for migraine and other pains by Burstein, Rami, Zhang, XiChun, Levy, Dan, Aoki, K Roger, Brin, Mitchell F

“…Meningeal and other trigeminal nociceptors are thought to play important roles in the initiation of migraine headache. Currently, the only approved…”
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Versatility of OnabotulinumtoxinA in Aesthetic Medicine by Brin, Mitchell F, Maltman, John, Chapman, Mary Ann, Sangha, Sara

“…OnabotulinumtoxinA is an injectable product that was introduced into medicine in the 1970s and has been the subject of thousands of clinical and nonclinical…”
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Treatment of pediatric spasticity, including children with cerebral palsy, with Botox (onabotulinumtoxinA): Development, insights, and impact by Gormley, Mark, Chambers, Henry G., Kim, Heakyung, Leon, Judith, Dimitrova, Rozalina, Brin, Mitchell F.

“…Spasticity is a velocity-dependent increase in muscle tone that has a negative effect on quality of life and hinders the ability of others to provide care. In…”
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Extracranial injections of botulinum neurotoxin type A inhibit intracranial meningeal nociceptors' responses to stimulation of TRPV1 and TRPA1 channels: Are we getting closer to solving this puzzle? by Zhang, XiChun, Strassman, Andrew M, Novack, Victor, Brin, Mitchell F, Burstein, Rami

“…Administration of onabotulinumtoxinA (BoNT-A) to peripheral tissues outside the calvaria reduces the number of days chronic migraine patients experience…”
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Treatment of strabismus and blepharospasm with Botox (onabotulinumtoxinA): Development, insights, and impact by Scott, Alan B., Fahn, Stanley, Brin, Mitchell F.

“…Strabismus, deviation of the ocular alignment, can adversely affect quality of life and activities of daily living. Surgery was the prior standard of care for…”
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Early development history of Botox (onabotulinumtoxinA) by Scott, Alan B., Honeychurch, Dennis, Brin, Mitchell F.

“…The development of Botox (onabotulinumtoxinA) began in the 1970s as Dr. Scott was attempting to identify an injectable substance that would weaken the…”
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Botulinum neurotoxins: Future innovations by Brideau-Andersen, Amy, Dolly, J. Oliver, Brin, Mitchell F.

“…Botulinum neurotoxins (BoNTs) are multi-domain proteins whose potent and selective actions on nerve endings have led to innovations in both basic and clinical…”
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Phase 3 efficacy and tolerability study of onabotulinumtoxinA for urinary incontinence from neurogenic detrusor overactivity by Ginsberg, David, Gousse, Angelo, Keppenne, Veronique, Sievert, Karl-Dietrich, Thompson, Catherine, Lam, Wayne, Brin, Mitchell F, Jenkins, Brenda, Haag-Molkenteller, Cornelia

“…We assessed the efficacy, safety and effects on quality of life of onabotulinumtoxinA in patients with neurogenic detrusor overactivity. In this 52-week,…”
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Treatment of glabellar lines with Botox (onabotulinumtoxinA): Development, insights, and impact by Carruthers, Jean, Carruthers, Alastair, Blitzer, Andrew, Eadie, Nina, Brin, Mitchell F.

“…OnabotulinumtoxinA is an injectable medication that produces muscle relaxation through local chemical denervation at the neuromuscular junction. Discovery of…”
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Modulation of amygdala activity for emotional faces due to botulinum toxin type A injections that prevent frowning by Stark, Shauna, Stark, Craig, Wong, Brian, Brin, Mitchell F.

“…According to the facial feedback hypothesis, when we see an angry or happy face, we contract or flex the relevant muscles to recreate the expression to assist…”
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Botulinum Neurotoxin Type A-Cleaved SNAP25 Is Confined to Primary Motor Neurons and Localized on the Plasma Membrane Following Intramuscular Toxin Injection by Cai, Brian B, Francis, Joseph, Brin, Mitchell F, Broide, Ron S

“…Highlights • Antibody specific to botulinum toxin A-cleaved SNAP25 plus 3-dimensional imaging offer insights into toxin distribution. • Botulinum toxin A…”
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Phenomenology, genetics, and CNS network abnormalities in laryngeal dystonia: A 30‐year experience by Blitzer, Andrew, Brin, Mitchell F., Simonyan, Kristina, Ozelius, Laurie J., Frucht, Steven J.

“…Objective Laryngeal dystonia (LD) is a functionally specific disorder of the afferent–efferent motor coordination system producing action‐induced muscle…”
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A Randomized Trial to Evaluate OnabotulinumtoxinA for Prevention of Headaches in Adolescents With Chronic Migraine by Winner, Paul K., Kabbouche, Marielle, Yonker, Marcy, Wangsadipura, Veronica, Lum, Arlene, Brin, Mitchell F.

“…Objective As a post‐approval commitment, this dose‐ranging study was undertaken to evaluate efficacy and safety of onabotulinumtoxinA in adolescents…”
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