Search Results - "Brill, Margreke J.E"

Impact of Obesity on Drug Metabolism and Elimination in Adults and Children by Brill, Margreke J. E., Diepstraten, Jeroen, van Rongen, Anne, van Kralingen, Simone, van den Anker, John N., Knibbe, Catherijne A. J.

“…The prevalence of obesity in adults and children is rapidly increasing across the world. Several general (patho)physiological alterations associated with…”
Get full text

Drug Disposition in Obesity: Toward Evidence-Based Dosing by Knibbe, Catherijne A.J, Brill, Margreke J.E, van Rongen, Anne, Diepstraten, Jeroen, van der Graaf, Piet Hein, Danhof, Meindert

“…Obesity and morbid obesity are associated with many physiological changes affecting pharmacokinetics, such as increased blood volume, cardiac output,…”
Get full text

Confirming model-predicted pharmacokinetic interactions between bedaquiline and lopinavir/ritonavir or nevirapine in patients with HIV and drug-resistant tuberculosis by Brill, Margreke J.E, Svensson, Elin M, Pandie, Mishal, Maartens, Gary, Karlsson, Mats O

“…Highlights • LPV/r increases bedaquiline exposure 2–3-fold in HIV/MDR-TB co-infected patients. • Nevirapine does not show a relevant effect on bedaquiline and…”
Get full text

Reduced subcutaneous tissue distribution of cefazolin in morbidly obese versus non-obese patients determined using clinical microdialysis by Brill, Margreke J E, Houwink, Aletta P I, Schmidt, Stephan, Van Dongen, Eric P A, Hazebroek, Eric J, van Ramshorst, Bert, Deneer, Vera H, Mouton, Johan W, Knibbe, Catherijne A J

“…As morbidly obese patients are prone to surgical site infections, adequate blood and subcutaneous tissue concentrations of prophylactic antibiotic agents…”
Get full text

Midazolam Pharmacokinetics in Morbidly Obese Patients Following Semi-Simultaneous Oral and Intravenous Administration: A Comparison with Healthy Volunteers by Brill, Margreke J. E., van Rongen, Anne, Houwink, Aletta P. I., Burggraaf, Jacobus, van Ramshorst, Bert, Wiezer, René J., van Dongen, Eric P. A., Knibbe, Catherijne A. J.

“…Background While in vitro and animal studies have shown reduced cytochrome P450 (CYP) 3A activity due to obesity, clinical studies in (morbidly) obese patients…”
Get full text

Characterization of Intestinal and Hepatic CYP3A-Mediated Metabolism of Midazolam in Children Using a Physiological Population Pharmacokinetic Modelling Approach by Brussee, Janneke M., Yu, Huixin, Krekels, Elke H. J., Palić, Semra, Brill, Margreke J. E., Barrett, Jeffrey S., Rostami-Hodjegan, Amin, de Wildt, Saskia N., Knibbe, Catherijne A. J.

“…Purpose Changes in drug absorption and first-pass metabolism have been reported throughout the pediatric age range. Our aim is to characterize both intestinal…”
Get full text

Higher Midazolam Clearance in Obese Adolescents Compared with Morbidly Obese Adults by van Rongen, Anne, Brill, Margreke J. E., Vaughns, Janelle D., Välitalo, Pyry A. J., van Dongen, Eric P. A., van Ramshorst, Bert, Barrett, Jeffrey S., van den Anker, Johannes N., Knibbe, Catherijne A. J.

“…Background The clearance of cytochrome P450 (CYP) 3A substrates is reported to be reduced with lower age, inflammation and obesity. As it is unknown what the…”
Get full text

First‐Pass CYP3A‐Mediated Metabolism of Midazolam in the Gut Wall and Liver in Preterm Neonates by Brussee, Janneke M., Yu, Huixin, Krekels, Elke H. J., de Roos, Berend, Brill, Margreke J. E., van den Anker, Johannes N., Rostami‐Hodjegan, Amin, de Wildt, Saskia N., Knibbe, Catherijne A. J.

“…To predict first‐pass and systemic cytochrome P450 (CYP) 3A‐mediated metabolism of midazolam in preterm neonates, a physiological population pharmacokinetic…”
Get full text

Model-Informed Translation of In Vitro Effects of Short-, Prolonged- and Continuous-Infusion Meropenem against Pseudomonas aeruginosa to Clinical Settings by Minichmayr, Iris K, Kappetein, Suzanne, Brill, Margreke J E, Friberg, Lena E

“…Pharmacokinetic-pharmacodynamic (PKPD) models have met increasing interest as tools to identify potential efficacious antibiotic dosing regimens in vitro and…”
Get full text

Population pharmacokinetic-pharmacodynamic model of propofol in adolescents undergoing scoliosis surgery with intraoperative wake-up test: a study using Bispectral index and composite auditory evoked potentials as pharmacodynamic endpoints by Blussé van Oud-Alblas, Heleen J, Brill, Margreke J E, Peeters, Mariska Y M, Tibboel, Dick, Danhof, Meindert, Knibbe, Catherijne A J

“…In adolescents limited data are available on the pharmacokinetics (PK) and pharmacodynamics (PD) of propofol. In this study we derived a PK-PD model for…”
Get full text