Search Results - "Brill, J E"

Impact of Obesity on Drug Metabolism and Elimination in Adults and Children by Brill, Margreke J. E., Diepstraten, Jeroen, van Rongen, Anne, van Kralingen, Simone, van den Anker, John N., Knibbe, Catherijne A. J.

“…The prevalence of obesity in adults and children is rapidly increasing across the world. Several general (patho)physiological alterations associated with…”
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Population pharmacokinetic-pharmacodynamic model of propofol in adolescents undergoing scoliosis surgery with intraoperative wake-up test: a study using Bispectral index and composite auditory evoked potentials as pharmacodynamic endpoints by Blussé van Oud-Alblas, Heleen J, Brill, Margreke J E, Peeters, Mariska Y M, Tibboel, Dick, Danhof, Meindert, Knibbe, Catherijne A J

“…In adolescents limited data are available on the pharmacokinetics (PK) and pharmacodynamics (PD) of propofol. In this study we derived a PK-PD model for…”
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Semi-mechanistic pharmacokinetic–pharmacodynamic modelling of antibiotic drug combinations by Brill, M.J.E., Kristoffersson, A.N., Zhao, C., Nielsen, E.I., Friberg, L.E.

“…Deriving suitable dosing regimens for antibiotic combination therapy poses several challenges as the drug interaction can be highly complex, the traditional…”
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Reduced subcutaneous tissue distribution of cefazolin in morbidly obese versus non-obese patients determined using clinical microdialysis by Brill, Margreke J E, Houwink, Aletta P I, Schmidt, Stephan, Van Dongen, Eric P A, Hazebroek, Eric J, van Ramshorst, Bert, Deneer, Vera H, Mouton, Johan W, Knibbe, Catherijne A J

“…As morbidly obese patients are prone to surgical site infections, adequate blood and subcutaneous tissue concentrations of prophylactic antibiotic agents…”
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Midazolam Pharmacokinetics in Morbidly Obese Patients Following Semi-Simultaneous Oral and Intravenous Administration: A Comparison with Healthy Volunteers by Brill, Margreke J. E., van Rongen, Anne, Houwink, Aletta P. I., Burggraaf, Jacobus, van Ramshorst, Bert, Wiezer, René J., van Dongen, Eric P. A., Knibbe, Catherijne A. J.

“…Background While in vitro and animal studies have shown reduced cytochrome P450 (CYP) 3A activity due to obesity, clinical studies in (morbidly) obese patients…”
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Characterization of Intestinal and Hepatic CYP3A-Mediated Metabolism of Midazolam in Children Using a Physiological Population Pharmacokinetic Modelling Approach by Brussee, Janneke M., Yu, Huixin, Krekels, Elke H. J., Palić, Semra, Brill, Margreke J. E., Barrett, Jeffrey S., Rostami-Hodjegan, Amin, de Wildt, Saskia N., Knibbe, Catherijne A. J.

“…Purpose Changes in drug absorption and first-pass metabolism have been reported throughout the pediatric age range. Our aim is to characterize both intestinal…”
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Drug Disposition in Obesity: Toward Evidence-Based Dosing by Knibbe, Catherijne A.J, Brill, Margreke J.E, van Rongen, Anne, Diepstraten, Jeroen, van der Graaf, Piet Hein, Danhof, Meindert

“…Obesity and morbid obesity are associated with many physiological changes affecting pharmacokinetics, such as increased blood volume, cardiac output,…”
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Model-Informed Translation of In Vitro Effects of Short-, Prolonged- and Continuous-Infusion Meropenem against Pseudomonas aeruginosa to Clinical Settings by Minichmayr, Iris K, Kappetein, Suzanne, Brill, Margreke J E, Friberg, Lena E

“…Pharmacokinetic-pharmacodynamic (PKPD) models have met increasing interest as tools to identify potential efficacious antibiotic dosing regimens in vitro and…”
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Confirming model-predicted pharmacokinetic interactions between bedaquiline and lopinavir/ritonavir or nevirapine in patients with HIV and drug-resistant tuberculosis by Brill, Margreke J.E, Svensson, Elin M, Pandie, Mishal, Maartens, Gary, Karlsson, Mats O

“…Highlights • LPV/r increases bedaquiline exposure 2–3-fold in HIV/MDR-TB co-infected patients. • Nevirapine does not show a relevant effect on bedaquiline and…”
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Population pharmacokinetics of colistin and the relation to survival in critically ill patients infected with colistin susceptible and carbapenem-resistant bacteria by Kristoffersson, A.N., Rognås, V., Brill, M.J.E., Dishon-Benattar, Y., Durante-Mangoni, E., Daitch, V., Skiada, A., Lellouche, J., Nutman, A., Kotsaki, A., Andini, R., Eliakim-Raz, N., Bitterman, R., Antoniadou, A., Karlsson, M.O., Theuretzbacher, U., Leibovici, L., Daikos, G.L., Mouton, J.W., Carmeli, Y., Paul, M., Friberg, L.E.

“…The aim was to analyse the population pharmacokinetics of colistin and to explore the relationship between colistin exposure and time to death. Patients…”
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Higher Midazolam Clearance in Obese Adolescents Compared with Morbidly Obese Adults by van Rongen, Anne, Brill, Margreke J. E., Vaughns, Janelle D., Välitalo, Pyry A. J., van Dongen, Eric P. A., van Ramshorst, Bert, Barrett, Jeffrey S., van den Anker, Johannes N., Knibbe, Catherijne A. J.

“…Background The clearance of cytochrome P450 (CYP) 3A substrates is reported to be reduced with lower age, inflammation and obesity. As it is unknown what the…”
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First‐Pass CYP3A‐Mediated Metabolism of Midazolam in the Gut Wall and Liver in Preterm Neonates by Brussee, Janneke M., Yu, Huixin, Krekels, Elke H. J., de Roos, Berend, Brill, Margreke J. E., van den Anker, Johannes N., Rostami‐Hodjegan, Amin, de Wildt, Saskia N., Knibbe, Catherijne A. J.

“…To predict first‐pass and systemic cytochrome P450 (CYP) 3A‐mediated metabolism of midazolam in preterm neonates, a physiological population pharmacokinetic…”
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Semiphysiologically based pharmacokinetic model for midazolam and CYP3A mediated metabolite 1‐OH‐midazolam in morbidly obese and weight loss surgery patients by Brill, MJE, Välitalo, PAJ, Darwich, AS, van Ramshorst, B, van Dongen, HPA, Rostami–Hodjegan, A, Danhof, M, Knibbe, CAJ

“…This study aimed to describe the pharmacokinetics of midazolam and its cytochrome P450 3A (CYP3A) mediated metabolite 1‐OH‐midazolam in morbidly obese patients…”
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Pharmacokinetic interaction between bedaquiline and clofazimine in patients with drug-resistant tuberculosis by Maartens, G., Brill, M. J. E., Pandie, M., Svensson, E. M.

“…BACKGROUND: Bedaquiline (BDQ) and clofazimine (CFZ) are both recommended for treating drug-resistant tuberculosis (DR-TB). As CFZ is an inhibitor of the…”
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Clinical Use of Continuous Arterial Blood Gas Monitoring in the Pediatric Intensive Care Unit by Weiss, Irwin K, Fink, Stan, Harrison, Rick, Feldman, Jonathan D, Brill, Judith E

“…Continuous arterial blood gas monitoring is a new technology based on the combination of opto-chemical and fiber-optic detectors that can measure pH, PCO2,…”
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Survival outcome among 54 intubated pediatric bone marrow transplant patients by Todd, K, Wiley, F, Landaw, E, Gajewski, J, Bellamy, P E, Harrison, R E, Brill, J E, Feig, S A

“…To assess the outcome of children who required endotracheal intubation after bone marrow transplantation and to determine whether prognostic indicators that…”
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Control of pain by Brill, J E

“…Pain in critically ill and injured pediatric patients may go unrecognized and undertreated since children often suffer silently and caretakers are often…”
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“High–dose” calcitriol for control of renal osteodystrophy in children on CAPD by Salusky, Isidro B., Fine, Richard N., Kangarloo, Hooshang, Gold, Richard, Paunier, Luc, Goodman, William G., Brill, Judith E., Gilli, Giulio, Slatopolsky, Eduardo, Coburn, Jack W.

“…“High–dose” calcitriol for control of renal osteodystrophy in children on CAPD. High doses of calcitriol were used prospectively for 11 to 29 months to raise…”
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Use of aminoglycosides during cyclosporine A immunosuppression after liver transplantation in children by Leach, C T, Kuhls, T L, Brill, J E, Busuttil, R W, Cherry, J D

“…To determine the frequency of renal dysfunction associated with the use of aminoglycosides with cyclosporine A (CyA) in children, the records of 26 consecutive…”
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The quality of survival after liver transplantation by Colonna, 2nd, J O, Brems, J J, Hiatt, J R, Millis, J M, Ament, M E, Baldrich-Quinones, W J, Berquist, W E, Besbris, D, Brill, J E, Goldstein, L I

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