Search Results - "Briles, David"

New Strategy Is Needed to Prevent Pneumococcal Meningitis by Mukerji, Reshmi, Briles, David E

“…BACKGROUND:Polysaccharide conjugate vaccines (PCVs) target the pneumococcal capsular types that most commonly cause fatal pneumonia and sepsis. Because these…”
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Streptococcus pneumoniae induces pyroptosis through the regulation of autophagy in murine microglia by Kim, Ji-Yun, Paton, James C, Briles, David E, Rhee, Dong-Kwon, Pyo, Suhkneung

“…Streptococcus pneumoniae is responsible for significant mortality and morbidity worldwide and causes invasive pneumococcal diseases including pneumococcal…”
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PspA-mediated aggregation protects Streptococcus pneumoniae against desiccation on fomites by Lane, Jessica R, Tata, Muralidhar, Yasmin, Rahena, Im, Hansol, Briles, David E, Orihuela, Carlos J

“…is a dangerous human pathogen capable of causing pneumonia and invasive disease. The virulence factor PspA has been studied for nearly four decades with…”
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Nanogel-Based PspA Intranasal Vaccine Prevents Invasive Disease and Nasal Colonization by Streptococcus pneumoniae by Kong, Il Gyu, Sato, Ayuko, Yuki, Yoshikazu, Nochi, Tomonori, Takahashi, Haruko, Sawada, Shinichi, Mejima, Mio, Kurokawa, Shiho, Okada, Kazunari, Sato, Shintaro, Briles, David E, Kunisawa, Jun, Inoue, Yusuke, Yamamoto, Masafumi, Akiyoshi, Kazunari, Kiyono, Hiroshi

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Streptococcus pneumoniae binds to host GAPDH on dying lung epithelial cells worsening secondary infection following influenza by Park, Sang-Sang, Gonzalez-Juarbe, Norberto, Riegler, Ashleigh N, Im, Hansol, Hale, Yvette, Platt, Maryann P, Croney, Christina, Briles, David E, Orihuela, Carlos J

“…Streptococcus pneumoniae (Spn) alone and during co-infection with influenza A virus (IAV) can result in severe pneumonia with mortality. Pneumococcal surface…”
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Novel Immunoprotective Proteins of Streptococcus pneumoniae Identified by Opsonophagocytosis Killing Screen by Wang, Yang, Wen, Zhensong, Pan, Xiaolei, Briles, David E, He, Yongqun, Zhang, Jing-Ren

“…The success of polysaccharide conjugate vaccines represents a major advance in the prevention of pneumococcal disease, but the power of these vaccines is…”
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A nanogel-based trivalent PspA nasal vaccine protects macaques from intratracheal challenge with pneumococci by Nakahashi-Ouchida, Rika, Uchida, Yohei, Yuki, Yoshikazu, Katakai, Yuko, Yamanoue, Tomoyuki, Ogawa, Hiromi, Munesue, Yoshiko, Nakano, Nozomi, Hanari, Kouji, Miyazaki, Takashi, Saito, Yuki, Umemoto, Shingo, Sawada, Shin-ichi, Mukerji, Reshmi, Briles, David E., Yasutomi, Yasuhiro, Akiyoshi, Kazunari, Kiyono, Hiroshi

“…•cCHP nanogel trivalent PspA vaccine effectively induces PspA-specific IgG in macaque.•PspA-specific IgG bound to the pneumococcal surface and triggered C3…”
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Characterization and Specification of a Trivalent Protein-Based Pneumococcal Vaccine Formulation Using an Adjuvant-Free Nanogel Nasal Delivery System by Yuki, Yoshikazu, Uchida, Yohei, Sawada, Shin-ichi, Nakahashi-Ouchida, Rika, Sugiura, Kotomi, Mori, Hiromi, Yamanoue, Tomoyuki, Machita, Tomonori, Honma, Ayaka, Kurokawa, Shiho, Mukerji, Reshmi, Briles, David E, Akiyoshi, Kazunari, Kiyono, Hiroshi

“…We previously developed a safe and effective nasal vaccine delivery system using a self-assembled nanosized hydrogel (nanogel) made from a cationic cholesteryl…”
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Pneumococcal capsular phase shift is associated with invasion into cell-to-cell junctions and is inhibited by macrolides by Takeda, Saori, Kono, Masamitsu, Sugita, Gen, Arai, Jun, Briles, David E., Hotomi, Muneki

“…Streptococcus pneumoniae frequently colonizes the human nasopharynx beginning in the early childhood. Pneumococci exhibit a spontaneous and reversible phase…”
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The diversity of the proline-rich domain of pneumococcal surface protein A (PspA): Potential relevance to a broad-spectrum vaccine by Mukerji, Reshmi, Hendrickson, Curtis, Genschmer, Kristopher R., Park, Sang-Sang, Bouchet, Valérie, Goldstein, Richard, Lefkowitz, Elliot J., Briles, David E.

“…•The proline rich domain (PRD) of PspA forms three distinct groups.•PRD Group 3 contains the highly conserved non-proline block (NPB).•There is no obligate…”
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A Jack of All Trades: The Role of Pneumococcal Surface Protein A in the Pathogenesis of Streptococcus pneumoniae by Lane, Jessica R, Tata, Muralidhar, Briles, David E, Orihuela, Carlos J

“…( ), or the pneumococcus, is a Gram-positive bacterium that colonizes the upper airway. is an opportunistic pathogen capable of life-threatening disease should…”
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Current status and perspectives on protein-based pneumococcal vaccines by Darrieux, Michelle, Goulart, Cibelly, Briles, David, Leite, Luciana Cezar de Cerqueira

“…Despite the efforts to expand the availability of conjugate vaccines, pneumococcal diseases still pose an enormous burden worldwide. Therefore, several…”
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Streptococcus pneumoniae Binds to Host Lactate Dehydrogenase via PspA and PspC To Enhance Virulence by Park, Sang-Sang, Gonzalez-Juarbe, Norberto, Martínez, Eriel, Hale, Joanetha Yvette, Lin, Yi-Han, Huffines, Joshua T, Kruckow, Katherine L, Briles, David E, Orihuela, Carlos J

“…Pneumococcal surface protein A (PspA) and pneumococcal surface protein C (PspC, also called CbpA) are major virulence factors of ( ). These surface-exposed…”
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Liver macrophages and sinusoidal endothelial cells execute vaccine-elicited capture of invasive bacteria by Wang, Juanjuan, An, Haoran, Ding, Ming, Liu, Yanhong, Wang, Shaomeng, Jin, Qian, Wu, Qi, Dong, Haodi, Guo, Qile, Tian, Xianbin, Liu, Jiankai, Zhang, Jingfei, Zhu, Tao, Li, Junqiang, Shao, Zhujun, Briles, David E, Veening, Jan-Willem, Zheng, Haifa, Zhang, Linqi, Zhang, Jing-Ren

“…Vaccination has substantially reduced the morbidity and mortality of bacterial diseases, but mechanisms of vaccine-elicited pathogen clearance remain largely…”
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Retention of structure, antigenicity, and biological function of pneumococcal surface protein A (PspA) released from polyanhydride nanoparticles by Haughney, Shannon L., Petersen, Latrisha K., Schoofs, Amy D., Ramer-Tait, Amanda E., King, Janice D., Briles, David E., Wannemuehler, Michael J., Narasimhan, Balaji

“…Pneumococcal surface protein A (PspA) is a choline-binding protein which is a virulence factor found on the surface of all Streptococcus pneumoniae strains…”
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Free Sialic Acid Acts as a Signal That Promotes Streptococcus pneumoniae Invasion of Nasal Tissue and Nonhematogenous Invasion of the Central Nervous System by Hatcher, Brandon L, Hale, Joanetha Y, Briles, David E

“…Streptococcus pneumoniae (pneumococcus) is a leading cause of bacterial meningitis and neurological sequelae in children worldwide. Acute bacterial meningitis…”
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PspA family distribution, antimicrobial resistance and serotype of Streptococcus pneumoniae isolated from upper respiratory tract infections in Japan by Hotomi, Muneki, Togawa, Akihisa, Kono, Masamitsu, Ikeda, Yorihiko, Takei, Shin, Hollingshead, Susan K, Briles, David E, Suzuki, Kenji, Yamanaka, Noboru

“…The protection against pneumococcal infections provided by currently available pneumococcal polysaccharide conjugate vaccines are restricted to the limited…”
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Basophils enhance immunological memory responses by Talke, Yvonne, Moll, Cordula, Kunz-Schughart, Leoni A, Maus, Ulrich A, Hollingshead, Susan, Mack, Matthias, Maus, Regina, Briles, David E, Denzel, Andrea, Niedermeier, Marianne, Winter, Christine, Gomez, Manuel Rodriguez

“…Basophils are associated mainly with allergy and immune responses to parasites. Mack and colleagues now show that 'antigen-specific' basophils contribute to…”
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Development of a Vaccine against Invasive Pneumococcal Disease Based on Combinations of Virulence Proteins of Streptococcus pneumoniae by OGUNNIYI, Abiodun D, GRABOWICZ, Marcin, BRILES, David E, COOK, Jan, PATON, James C

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A modified surface killing assay (MSKA) as a functional in vitro assay for identifying protective antibodies against pneumococcal surface protein A (PspA) by Genschmer, Kristopher R, Accavitti-Loper, Mary Ann, Briles, David E

“…Highlights • Antibodies elicited to PspA promote killing of wild type pneumococci by phagocytes on a surface. • Development of a potential in vitro functional…”
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