Search Results - "Brigitte Schmidt"

Structural analyses of NEAT1 lncRNAs suggest long-range RNA interactions that may contribute to paraspeckle architecture by Lin, Yizhu, Schmidt, Brigitte F, Bruchez, Marcel P, McManus, C Joel

“…Abstract Paraspeckles are nuclear bodies that regulate multiple aspects of gene expression. The long non-coding RNA (lncRNA) NEAT1 is essential for paraspeckle…”
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Esterase‐Activated, pH‐Responsive, and Genetically Targetable Nano‐Prodrug for Cancer Cell Photo‐Ablation by Liang, Pingping, Zhang, Yuanying, Schmidt, Brigitte F, Ballou, Byron, Qian, Wei, Dong, Ziyi, Wu, Jiahui, Wang, Lingling, Bruchez, Marcel P, Dong, Xiaochen

“…Activatable prodrugs have drawn considerable attention for cancer cell ablation owing to their high specificity in drug delivery systems. However,…”
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Fluorogen-activating single-chain antibodies for imaging cell surface proteins by Szent-Gyorgyi, Christopher, Waggoner, Alan, Schmidt, Brigitte F, Creeger, Yehuda, Fisher, Gregory W, Zakel, Kelly L, Adler, Sally, Fitzpatrick, James A J, Woolford, Carol A, Yan, Qi, Vasilev, Kalin V, Berget, Peter B, Bruchez, Marcel P, Jarvik, Jonathan W

“…Imaging of live cells has been revolutionized by genetically encoded fluorescent probes, most famously green and other fluorescent proteins, but also peptide…”
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Ca2+ and cAMP open differentially dilating synaptic fusion pores by Bulgari, Dinara, Cavolo, Samantha L, Schmidt, Brigitte F, Buchan, Katherine, Bruchez, Marcel P, Deitcher, David L, Levitan, Edwin S

“…Neuronal dense-core vesicles (DCVs) contain neuropeptides and much larger proteins that affect synaptic growth and plasticity. Rather than using full collapse…”
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Protein Proximity Observed Using Fluorogen Activating Protein and Dye Activated by Proximal Anchoring (FAP–DAPA) System by Carpenter, M. Alexandra, Wang, Yi, Telmer, Cheryl A, Schmidt, Brigitte F, Yang, Zhipeng, Bruchez, Marcel P

“…The development and function of tissues, blood, and the immune system is dependent upon proximity for cellular recognition and communication. However, the…”
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The strawberry-derived permeation enhancer pelargonidin enables oral protein delivery by Lamson, Nicholas G, Fein, Katherine C, Gleeson, John P, Newby, Alexandra N, Xian, Sijie, Cochran, Kyle, Chaudhary, Namit, Melamed, Jilian R, Ball, Rebecca L, Suri, Kanika, Ahuja, Vishal, Zhang, Anna, Berger, Adrian, Kolodieznyi, Dmytro, Schmidt, Brigitte F, Silva, Gloria L, Whitehead, Kathryn A

“…Although patients generally prefer oral drug delivery to injections, low permeability of the gastrointestinal tract makes this method impossible for most…”
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A PTEN-Regulated Checkpoint Controls Surface Delivery of δ Opioid Receptors by Shiwarski, Daniel J, Tipton, Alycia, Giraldo, Melissa D, Schmidt, Brigitte F, Gold, Michael S, Pradhan, Amynah A, Puthenveedu, Manojkumar A

“…The δ opioid receptor (δR) is a promising alternate target for pain management because δR agonists show decreased abuse potential compared with current opioid…”
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Activity-evoked and spontaneous opening of synaptic fusion pores by Bulgari, Dinara, Deitcher, David L., Schmidt, Brigitte F., Carpenter, M. Alexandra, Szent-Gyorgyi, Christopher, Bruchez, Marcel P., Levitan, Edwin S.

“…Synaptic release of neuropeptides packaged in dense-core vesicles (DCVs) regulates synapses, circuits, and behaviors including feeding, sleeping, and pain…”
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Reversible Click Chemistry Tag for Universal Proteome Sample Preparation for Top-Down and Bottom-Up Analysis by Biedka, Stephanie, Schmidt, Brigitte F., Frey, Nolan M., Boothman, Sarah M., Minden, Jonathan S., Wilson, Amber Lee

“…Successful proteome analysis requires reliable sample preparation beginning with protein solubilization and ending with a sample free of contaminants, ready…”
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Kidney urinary biomarkers in patients with branched‐chain amino acid and cobalamin metabolism defects by Köpfer, Felix, Garbade, Sven F., Klingbeil, Kristina, Schmidt‐Mader, Brigitte, Westhoff, Jens H., Okun, Jürgen G., Zorn, Markus, Hoffmann, Georg F., Peters, Verena, Morath, Marina

“…There is a clinical need for early detection of chronic kidney disease (CKD) in patients with organic acidurias. We measured kidney markers in a longitudinal…”
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Genetically Targeted Ratiometric and Activated pH Indicator Complexes (TRApHIC) for Receptor Trafficking by Perkins, Lydia A, Yan, Qi, Schmidt, Brigitte F, Kolodieznyi, Dmytro, Saurabh, Saumya, Larsen, Mads Breum, Watkins, Simon C, Kremer, Laura, Bruchez, Marcel P

“…Fluorescent protein-based pH sensors are useful tools for measuring protein trafficking through pH changes associated with endo- and exocytosis. However,…”
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A Chemoptogenetic Tool for Spatiotemporal Induction of Oxidative DNA Lesions In Vivo by Han, Suhao, Sims, Austin, Aceto, Anthony, Schmidt, Brigitte F, Bruchez, Marcel P, Gurkar, Aditi U

“…Oxidative nuclear DNA damage increases in all tissues with age in multiple animal models, as well as in humans. However, the increase in DNA oxidation varies…”
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Genetically Encoded pH Sensor for Tracking Surface Proteins through Endocytosis by Grover, Anmol, Schmidt, Brigitte F., Salter, Russell D., Watkins, Simon C., Waggoner, Alan S., Bruchez, Marcel P.

“…Traffic cam: A tandem dye prepared from a FRET acceptor and a fluorogenic donor functions as a cell surface ratiometric pH indicator, which upon…”
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Bottom-Up Design: A Modular Golden Gate Assembly Platform of Yeast Plasmids for Simultaneous Secretion and Surface Display of Distinct FAP Fusion Proteins by Szent-Gyorgyi, Christopher, Perkins, Lydia A., Schmidt, Brigitte F., Liu, Zhen, Bruchez, Marcel P., van de Weerd, Robert

“…A need in synthetic biology is the ability to precisely and efficiently make flexible fully designed vectors that addresses challenging cloning strategies of…”
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Affibody-targeted fluorogen activating protein for in vivo tumor imaging by Wang, Yi, Ballou, Byron, Schmidt, Brigitte F, Andreko, Sue, St Croix, Claudette M, Watkins, Simon C, Bruchez, Marcel P

“…Molecular imaging using near-infrared (NIR) fluorescence is useful for intraoperative imaging and real-time margin identification. Directly conjugated IR dyes…”
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High-Content Surface and Total Expression siRNA Kinase Library Screen with VX-809 Treatment Reveals Kinase Targets that Enhance F508del-CFTR Rescue by Perkins, Lydia A, Fisher, Gregory W, Naganbabu, Matharishwan, Schmidt, Brigitte F, Mun, Frederick, Bruchez, Marcel P

“…The most promising F508del-CFTR corrector, VX-809, has been unsuccessful as an effective, stand-alone treatment for CF patients, but the rescue effect in…”
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Intracellular pH Measurements Using Perfluorocarbon Nanoemulsions by Patrick, Michael J, Janjic, Jelena M, Teng, Haibing, O’Hear, Meredith R, Brown, Cortlyn W, Stokum, Jesse A, Schmidt, Brigitte F, Ahrens, Eric T, Waggoner, Alan S

“…We report the synthesis and formulation of unique perfluorocarbon (PFC) nanoemulsions enabling intracellular pH measurements in living cells via fluorescent…”
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Targeted cerebrospinal fluid analysis for inborn errors of metabolism on an LC‐MS/MS analysis platform by Klinke, Glynis, Richter, Sylvia, Monostori, Péter, Schmidt‐Mader, Brigitte, García‐Cazorla, Angels, Artuch, Rafael, Christ, Stine, Opladen, Thomas, Hoffmann, Georg F., Blau, Nenad, Okun, Jürgen G.

“…Background Laboratory investigations of cerebrospinal fluid (CSF) are essential when suspecting an inborn error of metabolism (IEM) involving neurological…”
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Determination of Characteristic vs Anomalous 135Cs/137Cs Isotopic Ratios in Radioactively Contaminated Environmental Samples by Zok, Dorian, Blenke, Tobias, Reinhard, Sandra, Sprott, Sascha, Kegler, Felix, Syrbe, Luisa, Querfeld, Rebecca, Takagai, Yoshitaka, Drozdov, Vladyslav, Chyzhevskyi, Ihor, Kirieiev, Serhii, Schmidt, Brigitte, Adlassnig, Wolfram, Wallner, Gabriele, Dubchak, Sergiy, Steinhauser, Georg

“…A contamination with the ubiquitous radioactive fission product 137Cs cannot be assigned per se to its source. We used environmental samples with varying…”
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Near-instant surface-selective fluorogenic protein quantification using sulfonated triarylmethane dyes and fluorogen activating proteins by Yan, Qi, Schmidt, Brigitte F, Perkins, Lydia A, Naganbabu, Matharishwan, Saurabh, Saumya, Andreko, Susan K, Bruchez, Marcel P

“…Agonist-promoted G-protein coupled receptor (GPCR) endocytosis and recycling plays an important role in many signaling events in the cell. However, the…”
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