Search Results - "Brighton, Cheryl"

Bile Acids Trigger GLP-1 Release Predominantly by Accessing Basolaterally Located G Protein–Coupled Bile Acid Receptors by Brighton, Cheryl A, Rievaj, Juraj, Kuhre, Rune E, Glass, Leslie L, Schoonjans, Kristina, Holst, Jens J, Gribble, Fiona M, Reimann, Frank

“…Bile acids are well-recognized stimuli of glucagon-like peptide-1 (GLP-1) secretion. This action has been attributed to activation of the G protein–coupled…”
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Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension by Azizan, Elena A B, Poulsen, Hanne, Tuluc, Petronel, Zhou, Junhua, Clausen, Michael V, Lieb, Andreas, Maniero, Carmela, Garg, Sumedha, Bochukova, Elena G, Zhao, Wanfeng, Shaikh, Lalarukh Haris, Brighton, Cheryl A, Teo, Ada E D, Davenport, Anthony P, Dekkers, Tanja, Tops, Bas, Küsters, Benno, Ceral, Jiri, Yeo, Giles S H, Neogi, Sudeshna Guha, McFarlane, Ian, Rosenfeld, Nitzan, Marass, Francesco, Hadfield, James, Margas, Wojciech, Chaggar, Kanchan, Solar, Miroslav, Deinum, Jaap, Dolphin, Annette C, Farooqi, I Sadaf, Striessnig, Joerg, Nissen, Poul, Brown, Morris J

“…Morris Brown and colleagues identify somatic mutations in ATP1A1 and CACNA1D in aldosterone-producing adenomas with features resembling zonaglomerulosa cells…”
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High fat diet impairs the function of glucagon-like peptide-1 producing L-cells by Richards, Paul, Pais, Ramona, Habib, Abdella M., Brighton, Cheryl A., Yeo, Giles S.H., Reimann, Frank, Gribble, Fiona M.

“…•Long term dietary changes impair function of the gut endocrine system.•High fat diet impairs nutrient-triggered GLP-1 release from murine small…”
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Inhibition of mitochondrial function by metformin increases glucose uptake, glycolysis and GDF-15 release from intestinal cells by Yang, Ming, Darwish, Tamana, Larraufie, Pierre, Rimmington, Debra, Cimino, Irene, Goldspink, Deborah A., Jenkins, Benjamin, Koulman, Albert, Brighton, Cheryl A., Ma, Marcella, Lam, Brian Y. H., Coll, Anthony P., O’Rahilly, Stephen, Reimann, Frank, Gribble, Fiona M.

“…Even though metformin is widely used to treat type2 diabetes, reducing glycaemia and body weight, the mechanisms of action are still elusive. Recent studies…”
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Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells by Trabelsi, Mohamed-Sami, Daoudi, Mehdi, Prawitt, Janne, Ducastel, Sarah, Touche, Véronique, Sayin, Sama I., Perino, Alessia, Brighton, Cheryl A., Sebti, Yasmine, Kluza, Jérôme, Briand, Olivier, Dehondt, Hélène, Vallez, Emmanuelle, Dorchies, Emilie, Baud, Grégory, Spinelli, Valeria, Hennuyer, Nathalie, Caron, Sandrine, Bantubungi, Kadiombo, Caiazzo, Robert, Reimann, Frank, Marchetti, Philippe, Lefebvre, Philippe, Bäckhed, Fredrik, Gribble, Fiona M., Schoonjans, Kristina, Pattou, François, Tailleux, Anne, Staels, Bart, Lestavel, Sophie

“…Bile acids are signalling molecules, which activate the transmembrane receptor TGR5 and the nuclear receptor FXR. BA sequestrants (BAS) complex bile acids in…”
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Mixed Primary Cultures of Murine Small Intestine Intended for the Study of Gut Hormone Secretion and Live Cell Imaging of Enteroendocrine Cells by Psichas, Arianna, Tolhurst, Gwen, Brighton, Cheryl A, Gribble, Fiona M, Reimann, Frank

“…The gut is the largest endocrine organ of the body, with hormone-secreting enteroendocrine cells located along the length of the gastrointestinal epithelium…”
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The severity of hereditary porphyria is modulated by the porphyrin exporter and Lan antigen ABCB6 by Fukuda, Yu, Cheong, Pak Leng, Lynch, John, Brighton, Cheryl, Frase, Sharon, Kargas, Vasileios, Rampersaud, Evadnie, Wang, Yao, Sankaran, Vijay G., Yu, Bing, Ney, Paul A., Weiss, Mitchell J., Vogel, Peter, Bond, Peter J., Ford, Robert C., Trent, Ronald J., Schuetz, John D.

“…Hereditary porphyrias are caused by mutations in genes that encode haem biosynthetic enzymes with resultant buildup of cytotoxic metabolic porphyrin…”
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Relaxin/insulin-like family peptide receptor 4 (Rxfp4) expressing hypothalamic neurons modulate food intake and preference in mice by Lewis, Jo E., Woodward, Orla RM, Nuzzaci, Danaé, Smith, Christopher A., Adriaenssens, Alice E., Billing, Lawrence, Brighton, Cheryl, Phillips, Benjamin U., Tadross, John A., Kinston, Sarah J., Ciabatti, Ernesto, Göttgens, Berthold, Tripodi, Marco, Hornigold, David, Baker, David, Gribble, Fiona M., Reimann, Frank

“…Insulin-like peptide 5 (INSL5) signalling, through its cognate receptor relaxin/insulin-like family peptide receptor 4 (RXFP4), has been reported to be…”
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DACH1, a zona glomerulosa selective gene in the human adrenal, activates transforming growth factor-β signaling and suppresses aldosterone secretion by Zhou, Junhua, Shaikh, Lalarukh Haris, Neogi, Sudeshna G, McFarlane, Ian, Zhao, Wanfeng, Figg, Nichola, Brighton, Cheryl A, Maniero, Carmela, Teo, Ada E D, Azizan, Elena A B, Brown, Morris J

“…Common somatic mutations in CACNAID and ATP1A1 may define a subgroup of smaller, zona glomerulosa (ZG)-like aldosterone-producing adenomas. We have therefore…”
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Characterisation of inverse agonism of the orphan-G protein-coupled receptor GPR52 by cannabinoid ligands Cannabidiol and O-1918 by Stott, Lisa A., Brighton, Cheryl A., Brown, Jason, Mould, Richard, Bennett, Kirstie A., Newman, Robert, Currinn, Heather, Autore, Flavia, Higueruelo, Alicia P., Tehan, Benjamin G., MacSweeney, Cliona, O'Brien, Michael A., Watson, Steve P.

“…The identification of cannabinoid ligands Cannabidiol and O-1918 as inverse agonists of the orphan receptor GPR52 is reported. Detailed characterisation of…”
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Mixed Primary Cultures of Murine Small Intestine Intended for the Study of Gut Hormone Secretion and Live Cell Imaging of Enteroendocrine Cells by Psichas, Arianna, Tolhurst, Gwen, Brighton, Cheryl A., Gribble, Fiona M., Reimann, Frank

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