Search Results - "Bright, Damian P."

Structural determinants and regulation of spontaneous activity in GABAA receptors by Sexton, Craig A., Penzinger, Reka, Mortensen, Martin, Bright, Damian P., Smart, Trevor G.

“…GABA A receptors are vital for controlling neuronal excitability and can display significant levels of constitutive activity that contributes to tonic…”
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Two-pore-domain K+ channels are a novel target for the anesthetic gases xenon, nitrous oxide, and cyclopropane by Gruss, Marco, Bushell, Trevor J, Bright, Damian P, Lieb, William R, Mathie, Alistair, Franks, Nicholas P

“…Nitrous oxide, xenon, and cyclopropane are anesthetic gases that have a distinct pharmacological profile. Whereas the molecular basis for their anesthetic…”
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Intracellular Chloride Ions Regulate the Time Course of GABA-Mediated Inhibitory Synaptic Transmission by Houston, Catriona M, Bright, Damian P, Sivilotti, Lucia G, Beato, Marco, Smart, Trevor G

“…The time-dependent integration of excitatory and inhibitory synaptic currents is an important process for shaping the input-output profiles of individual…”
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Acting locally but sensing globally: impact of GABAergic synaptic plasticity on phasic and tonic inhibition in the thalamus by Bright, Damian P., Brickley, Stephen G.

“…We have discovered that adult thalamocortical relay neurones exhibit a sustained enhancement of synaptic inhibition triggered by transient action potential…”
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Pre- and postsynaptic modulation of hippocampal inhibitory synaptic transmission by pregnenolone sulphate by Seljeset, Sandra, Liebowitz, Seth, Bright, Damian P., Smart, Trevor G.

“…Neurosteroids are important endogenous modulators of GABAA receptor-mediated neurotransmission within the CNS and play a vital role in maintaining normal…”
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Forty Years Searching for Neurosteroid Binding Sites on GABAA Receptors by Mortensen, Martin, Bright, Damian P., Fagotti, Juliane, Dorovykh, Valentina, Cerna, Barbora, Smart, Trevor G.

“…•Neurosteroids are modulators of GABAA receptors.•Neurosteroids can potentiate, directly activate, and inhibit GABAAR function.•This review charts the…”
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Probing GABA A receptors with inhibitory neurosteroids by Seljeset, Sandra, Bright, Damian P, Thomas, Philip, Smart, Trevor G

“…γ-aminobutyric acid type A receptors (GABA Rs) are important components of the central nervous system and they are functionally tasked with controlling…”
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Probing GABAA receptors with inhibitory neurosteroids by Seljeset, Sandra, Bright, Damian P., Thomas, Philip, Smart, Trevor G.

“…γ-aminobutyric acid type A receptors (GABAARs) are important components of the central nervous system and they are functionally tasked with controlling…”
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Protein kinase C regulates tonic GABAA receptor-mediated inhibition in the hippocampus and thalamus by Bright, Damian P., Smart, Trevor G.

“…Tonic inhibition mediated by extrasynaptic GABAA receptors (GABAARs) is an important regulator of neuronal excitability. Phosphorylation by protein kinase C…”
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Protein kinase C regulates tonic GABA(A) receptor-mediated inhibition in the hippocampus and thalamus by Bright, Damian P, Smart, Trevor G

“…Tonic inhibition mediated by extrasynaptic GABA(A) receptors (GABA(A) Rs) is an important regulator of neuronal excitability. Phosphorylation by protein kinase…”
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Synaptic Release Generates a Tonic GABAA Receptor-Mediated Conductance That Modulates Burst Precision in Thalamic Relay Neurons by Bright, Damian P, Aller, M. Isabel, Brickley, Stephen G

“…Tonic inhibition has emerged as a key regulator of neuronal excitability in the CNS. Thalamic relay neurons of the dorsal lateral geniculate nucleus (dLGN)…”
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Profound desensitization by ambient GABA limits activation of δ-containing GABAA receptors during spillover by Bright, Damian P, Renzi, Massimiliano, Bartram, Julian, McGee, Thomas P, MacKenzie, Georgina, Hosie, Alastair M, Farrant, Mark, Brickley, Stephen G

“…High-affinity extrasynaptic GABA(A) receptors (GABA(A)Rs) are a prominent feature of cerebellar granule neurons and thalamic relay neurons. In both cell types,…”
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Methods for recording and measuring tonic GABAA receptor-mediated inhibition by Bright, Damian P, Smart, Trevor G

“…Tonic inhibitory conductances mediated by GABAA receptors have now been identified and characterized in many different brain regions. Most experimental studies…”
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Context-Dependent Modulation of GABAAR-Mediated Tonic Currents by Patel, Bijal, Bright, Damian P, Mortensen, Martin, Frølund, Bente, Smart, Trevor G

“…Tonic GABA currents mediated by high-affinity extrasynaptic GABAA receptors, are increasingly recognized as important regulators of cell and neuronal network…”
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Synaptic release generates a tonic GABA(A) receptor-mediated conductance that modulates burst precision in thalamic relay neurons by Bright, Damian P, Aller, M Isabel, Brickley, Stephen G

“…Tonic inhibition has emerged as a key regulator of neuronal excitability in the CNS. Thalamic relay neurons of the dorsal lateral geniculate nucleus (dLGN)…”
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Identification of Anesthetic Binding Sites on Human Serum Albumin Using a Novel Etomidate Photolabel by Bright, Damian P., Adham, Sara D., Lemaire, Lucienne C.J.M., Benavides, Rodrigo, Gruss, Marco, Taylor, Graham W., Smith, Edward H., Franks, Nicholas P.

“…We have synthesized a novel analog of the general anesthetic etomidate in which the ethoxy group has been replaced by an azide group, and which can be used as…”
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Structural determinants and regulation of spontaneous activity in GABA A receptors by Sexton, Craig A, Penzinger, Reka, Mortensen, Martin, Bright, Damian P, Smart, Trevor G

“…GABA receptors are vital for controlling neuronal excitability and can display significant levels of constitutive activity that contributes to tonic…”
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Tyrosine phosphorylation of GABAA receptor γ2-subunit regulates tonic and phasic inhibition in the thalamus by Nani, Francesca, Bright, Damian P, Revilla-Sanchez, Raquel, Tretter, Verena, Moss, Stephen J, Smart, Trevor G

“…GABA-mediated tonic and phasic inhibition of thalamic relay neurons of the dorsal lateral geniculate nucleus (dLGN) was studied after ablating tyrosine (Y)…”
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Forty years searching for neurosteroid binding sites on GABA A receptors by Mortensen, Martin, Bright, Damian P, Fagotti, Juliane, Dorovykh, Valentina, Cerna, Barbora, Smart, Trevor G

“…Brain inhibition is a vital process for controlling and sculpting the excitability of the central nervous system in healthy individuals. This level of control…”
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Profound Desensitization by Ambient GABA Limits Activation of δ-Containing GABA A Receptors during Spillover by Bright, Damian P., Renzi, Massimiliano, Bartram, Julian, McGee, Thomas P., MacKenzie, Georgina, Hosie, Alastair M., Farrant, Mark, Brickley, Stephen G.

“…High-affinity extrasynaptic GABA A receptors (GABA A Rs) are a prominent feature of cerebellar granule neurons and thalamic relay neurons. In both cell types,…”
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