Search Results - "Briggs, James M."

Inhibition of Cholera Toxin and Other AB Toxins by Polyphenolic Compounds by Cherubin, Patrick, Garcia, Maria Camila, Curtis, David, Britt, Christopher B T, Craft, Jr, John W, Burress, Helen, Berndt, Chris, Reddy, Srikar, Guyette, Jessica, Zheng, Tianyu, Huo, Qun, Quiñones, Beatriz, Briggs, James M, Teter, Ken

“…Cholera toxin (CT) is an AB-type protein toxin that contains a catalytic A1 subunit, an A2 linker, and a cell-binding B homopentamer. The CT holotoxin is…”
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Antibody mix-and-read assays based on fluorescence intensity probes by Patil, Ujwal, Goyal, Atul, Vu, Binh, Liu, Yanyun, Maranholkar, Vijay, Kourentzi, Katerina, Briggs, James M, Willson, Richard C

“…Antibodies and Fc fusion proteins are a rapidly growing class of pharmaceuticals. Cell culture and purification process development and operation require…”
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The tilting motion of the central core reveals the transport mechanism of the sarco/endoplasmic reticulum Ca2+-ATPase by Ma, Rulong, Briggs, James M.

“…The sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) transports two Ca2+ ions per ATP hydrolyzed from the cytoplasm to the lumen. However, how the ATP…”
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The tilting motion of the central core reveals the transport mechanism of the sarco/endoplasmic reticulum Ca 2+ -ATPase by Ma, Rulong, Briggs, James M

“…The sarco/endoplasmic reticulum Ca -ATPase (SERCA) transports two Ca ions per ATP hydrolyzed from the cytoplasm to the lumen. However, how the ATP hydrolysis…”
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New insights into the binding and catalytic mechanisms of Bacillus thuringiensis lactonase: insights into B. thuringiensis AiiA mechanism by Charendoff, Marc N, Shah, Halie P, Briggs, James M

“…The lactonase enzyme (AiiA) produced by Bacillus thuringiensis serves to degrade autoinducer-1 (AI-1) signaling molecules in what is an evolved mechanism by…”
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Functional Implications of the spectrum of BCL2 mutations in Lymphoma by Singh, Khushboo, Briggs, James M.

“…Mutations in the translocated BCL2 gene are often detected in diffuse large B-cell lymphomas (DLBCLs), indicating both their significance and pervasiveness…”
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Dynamic Receptor-Based Pharmacophore Model Development and Its Application in Designing Novel HIV-1 Integrase Inhibitors by Deng, Jinxia, Lee, Keun Woo, Sanchez, Tino, Cui, Meng, Neamati, Nouri, Briggs, James M

“…We present here a dynamic receptor-based pharmacophore model representing the complementary features of the active site region of HIV-1 integrase (IN), which…”
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Structural mutation analysis of PTEN and its genotype-phenotype correlations in endometriosis and cancer by Smith, Iris N., Briggs, James M.

“…ABSTRACT The phosphatase and tensin homolog deleted on chromosome ten (PTEN) gene encodes a tumor suppressor phosphatase that has recently been found to be…”
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Pharmacophore Oriented MP2 Characterization of Charge Distribution for Anti-SARS-CoV-2 Inhibitor Nirmatrelvir by Liu, Yuemin, Ma, Rulong, Fan, Huajun, Johnson, Bruce R., Briggs, James M.

“…•Structural optimizations of Nirmatrelvir with 67 atoms were performed using high level MP2/6-311+G* and DFT methods.•MK ESP, Hirshfeld, CM5, NBO, and mulliken…”
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Dopamine D1 Receptor Agonist and D2 Receptor Antagonist Effects of the Natural Product (−)–Stepholidine: Molecular Modeling and Dynamics Simulations by Fu, Wei, Shen, Jianhua, Luo, Xiaomin, Zhu, Weiliang, Cheng, Jiagao, Yu, Kunqian, Briggs, James M., Jin, Guozhang, Chen, Kaixian, Jiang, Hualiang

“…(−)–Stepholidine (SPD), an active ingredient of the Chinese herb Stephania, is the first compound found to have dual function as a dopamine receptor D1 agonist…”
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Impact of lymphoma‐linked Asn11Tyr point mutation on the interaction between Bcl‐2 and a BH3 mimetic: Insights from molecular dynamics simulation by Singh, Khushboo, Briggs, James M.

“…Frequent mutations in the Bcl‐2 anti‐apoptotic protein are often implicated in diffuse large B‐cell lymphoma (DLBCL), a disease profoundly resistant to drugs…”
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Insights into the substrate binding specificity of quorum-quenching acylase PvdQ by Liu, Yanyun, Ebalunode, Jerry O., Briggs, James M.

“…Quorum sensing is a cell to cell signaling mechanism that enables them to coordinate their behaviors in a density-dependent manner mediated by small diffusible…”
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Heterotropic roles of divalent cations in the establishment of allostery and affinity maturation of integrin αXβ2 by Manandhar, Pragya, Mazhar, Zahra, Abousaway, Omar, Aboagye, Collins, Moussa, Zeinab, Lim, Daniel, Yu, Tannon, Byrnes, James, Briggs, James M., Sen, Mehmet

“…Allosteric activation and silencing of leukocyte β2-integrins transpire through cation-dependent structural changes, which mediate integrin biosynthesis and…”
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Electrostatic and non-electrostatic contributions to the binding free energies of anthracycline antibiotics to DNA by Baginski, Maciej, Fogolari, Federico, Briggs, James M

“…The knowledge about molecular factors driving simple ligand-DNA interactions is still limited. The aim of the present study was to investigate the…”
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RNAdemocracy: an ensemble method for RNA secondary structure prediction using consensus scoring by Skidmore, Benjamin L., Briggs, James M.

“…[Display omitted] •A structure prediction approach finding consensus within established methods•Able to compete with established methods but does not best…”
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Modulation of Substrate Specificity within the Amino Acid Editing Site of Leucyl-tRNA Synthetase by Zhai, Yuxin, Nawaz, Mir Hussain, Lee, Keun Woo, Kirkbride, Erin, Briggs, James M, Martinis, Susan A

“…The aminoacyl-tRNA synthetases covalently link transfer RNAs to their cognate amino acids. Some of the tRNA synthetases have evolved editing mechanisms to…”
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Molecular modeling study of the editing active site of Escherichia coli leucyl-tRNA synthetase: Two amino acid binding sites in the editing domain by Lee, Keun Woo, Briggs, James M.

“…Aminoacyl‐tRNA synthetases (aaRSs) strictly discriminate their cognate amino acids. Some aaRSs accomplish this via proofreading and editing mechanisms…”
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Screening of Focused Compound Library Targeting Liver X Receptors in Pancreatic Cancer Identified Ligands with Inverse Agonist and Degrader Activity by Karaboga, Husna, Huang, Wentao, Srivastava, Shivangi, Widmann, Scott, Addanki, Sridevi, Gamage, Kasuni Thawalama, Mazhar, Zahra, Ebalunode, Jerry O, Briggs, James M, Gustafsson, Jan-Åke, Filgueira, Carly S, Gilbertson, Scott R, Lin, Chin-Yo

“…Pancreatic ductal adenocarcinoma (PDAC) is the predominant form of pancreatic cancer. PDACs harbor oncogenic mutations in the KRAS gene, and ongoing efforts to…”
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Mechanistic role of NS4A and substrate in the activation of HCV NS3 protease by Zhu, Haimei, Briggs, James M.

“…Hepatitis C virus (HCV) NS3 protease is the key enzyme for its maturation. Three hypotheses have been advanced in the literature to demonstrate the mechanism…”
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QM/MM study of N501 involved intermolecular interaction between SARS-CoV-2 receptor binding domain and antibody of human origin by Liu, Yuemin, Sulaiman, Hana F., Johnson, Bruce R., Ma, Rulong, Gao, Yunxiang, Fernando, Harshica, Amarasekara, Ananda, Ashley-Oyewole, Andrea, Fan, Huajun, Ingram, Heaven N., Briggs, James M.

“…Intermolecular interaction between key residue N501 of the epitope on SARS-CoV-2 RBD and screening antibody B38 was studied using the QM/MM and QM approach…”
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