Search Results - "Briggs, Deborah A"

Rab27a co-ordinates actin-dependent transport by controlling organelle-associated motors and track assembly proteins by Alzahofi, Noura, Welz, Tobias, Robinson, Christopher L., Page, Emma L., Briggs, Deborah A., Stainthorp, Amy K., Reekes, James, Elbe, David A., Straub, Felix, Kallemeijn, Wouter W., Tate, Edward W., Goff, Philip S., Sviderskaya, Elena V., Cantero, Marta, Montoliu, Lluis, Nedelec, Francois, Miles, Amanda K., Bailly, Maryse, Kerkhoff, Eugen, Hume, Alistair N.

“…Cell biologists generally consider that microtubules and actin play complementary roles in long- and short-distance transport in animal cells. On the contrary,…”
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Myosin-Va and Dynamic Actin Oppose Microtubules to Drive Long-Range Organelle Transport by Evans, Richard D., Robinson, Christopher, Briggs, Deborah A., Tooth, David J., Ramalho, Jose S., Cantero, Marta, Montoliu, Lluis, Patel, Shyamal, Sviderskaya, Elena V., Hume, Alistair N.

“…In animal cells, microtubule and actin tracks and their associated motors (dynein, kinesin, and myosin) are thought to regulate long- and short-range…”
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The adaptor protein melanophilin regulates dynamic myosin-Va:cargo interaction and dendrite development in melanocytes by Robinson, Christopher L, Evans, Richard D, Sivarasa, Kajana, Ramalho, Jose S, Briggs, Deborah A, Hume, Alistair N

“…The regulation of organelle transport by the cytoskeleton is fundamental for eukaryotic survival. Cytoskeleton motors are typically modular proteins with…”
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Nucleotide exchange factor Rab3GEP requires DENN and non-DENN elements for activation and targeting of Rab27a by Sanzà, Paolo, Evans, Richard D, Briggs, Deborah A, Cantero, Marta, Montoliu, Lluis, Patel, Shyamal, Sviderskaya, Elena V, Itzen, Aymelt, Figueiredo, Ana C, Seabra, Miguel C, Hume, Alistair N

“…Rab GTPases are compartment-specific molecular switches that regulate intracellular vesicular transport in eukaryotes. GDP/GTP exchange factors (GEFs) control…”
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Disruption of the Unique ABCG-Family NBD:NBD Interface Impacts Both Drug Transport and ATP Hydrolysis by Kapoor, Parth, Briggs, Deborah A, Cox, Megan H, Kerr, Ian D

“…ABCG2 is one of a triumvirate of human multidrug ATP binding cassette (ABC) transporters that are implicated in the defense of cells and tissues against…”
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Actomyosin organelle functions of SPIRE actin nucleators precede animal evolution by Kollmar, Martin, Welz, Tobias, Ravi, Aishwarya, Kaufmann, Thomas, Alzahofi, Noura, Hatje, Klas, Alghamdi, Asmahan, Kim, Jiyu, Briggs, Deborah A., Samol-Wolf, Annette, Pylypenko, Olena, Hume, Alistair N., Burkhardt, Pawel, Faix, Jan, Kerkhoff, Eugen

“…An important question in cell biology is how cytoskeletal proteins evolved and drove the development of novel structures and functions. Here we address the…”
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Application of fluorescence correlation spectroscopy to study substrate binding in styrene maleic acid lipid copolymer encapsulated ABCG2 by Horsey, Aaron J., Briggs, Deborah A., Holliday, Nicholas D., Briddon, Stephen J., Kerr, Ian D.

“…ABCG2 is one of a trio of human ATP binding cassette transporters that have the ability to bind and transport a diverse array of chemical substrates out of…”
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A time-resolved Förster resonance energy transfer assay to investigate drug and inhibitor binding to ABCG2 by Mitchell-White, James I., Briggs, Deborah A., Mistry, Sarah J., Mbiwan, Hannah A., Kellam, Barrie, Holliday, Nicholas D., Briddon, Stephen J., Kerr, Ian D.

“…The human ATP-binding cassette (ABC) transporter, ABCG2, is responsible for multidrug resistance in some tumours. Detailed knowledge of its activity is crucial…”
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Cross-linking, DEER-spectroscopy and molecular dynamics confirm the inward facing state of P-glycoprotein in a lipid membrane by Carey Hulyer, Alex R., Briggs, Deborah A., O'Mara, Megan L., Kerr, Ian D., Harmer, Jeffrey R., Callaghan, Richard

“…[Display omitted] •How well do structural models describe the structure of P-glycoprotein in membranes.•Membrane helices 6 and 12 in link energy provision,…”
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Inefficient recruitment of kinesin-1 to melanosomes precludes it from facilitating their transport by Robinson, Christopher L, Evans, Richard D, Briggs, Deborah A, Ramalho, Jose S, Hume, Alistair N

“…Microtubules and F-actin, and their associated motor proteins, are considered to play complementary roles in long- and short-range organelle transport…”
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Novel RAB27A Variant Associated with Late-Onset Hemophagocytic Lymphohistiocytosis Alters Effector Protein Binding by Zondag, Timo C. E., Torralba-Raga, Lamberto, Van Laar, Jan A. M., Hermans, Maud A. W., Bouman, Arjen, Hollink, Iris H. I. M., Van Hagen, P. Martin, Briggs, Deborah A., Hume, Alistair N., Bryceson, Yenan T.

“…Autosomal recessive mutations in RAB27A are associated with Griscelli syndrome type 2 (GS2), characterized by hypopigmentation and development of early-onset,…”
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Induction of a stress response in Lactococcus lactis is associated with a resistance to ribosomally active antibiotics by Dorrian, James M., Briggs, Deborah A., Ridley, Michael L., Layfield, Robert, Kerr, Ian D.

“…The acquisition of multidrug resistance in bacteria underlies the failure of antimicrobial therapy, and the emergence of pathogens that are resistant to almost…”
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Induction of a stress response in Lactococcuslactis is associated with a resistance to ribosomally active antibiotics by Dorrian, James M, Briggs, Deborah A, Ridley, Michael L, Layfield, Robert, Kerr, Ian D

“…The acquisition of multidrug resistance in bacteria underlies the failure of antimicrobial therapy, and the emergence of pathogens that are resistant to almost…”
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Reduced uncoupling protein (UCP)-3 in human colonic malignancy by Bennett, Andrew J., Briggs, Deborah A., Jackson, Lucina M., Hawkey, Chris J., White, David A.

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