Search Results - "Briggs, Adrian"
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Optimization of scarless human stem cell genome editing
Published in Nucleic acids research (01-10-2013)“…Efficient strategies for precise genome editing in human-induced pluripotent cells (hiPSCs) will enable sophisticated genome engineering for research and…”
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2
Removal of deaminated cytosines and detection of in vivo methylation in ancient DNA
Published in Nucleic acids research (01-04-2010)“…DNA sequences determined from ancient organisms have high error rates, primarily due to uracil bases created by cytosine deamination. We use synthetic…”
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3
Hierarchical Clustering Can Identify B Cell Clones with High Confidence in Ig Repertoire Sequencing Data
Published in The Journal of immunology (1950) (15-03-2017)“…Adaptive immunity is driven by the expansion, somatic hypermutation, and selection of B cell clones. Each clone is the progeny of a single B cell responding to…”
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4
Genetic history of an archaic hominin group from Denisova Cave in Siberia
Published in Nature (London) (23-12-2010)“…Using DNA extracted from a finger bone found in Denisova Cave in southern Siberia, we have sequenced the genome of an archaic hominin to about 1.9-fold…”
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5
Iterative capped assembly: rapid and scalable synthesis of repeat-module DNA such as TAL effectors from individual monomers
Published in Nucleic acids research (01-08-2012)“…DNA built from modular repeats presents a challenge for gene synthesis. We present a solid surface-based sequential ligation approach, which we refer to as…”
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6
A Complete mtDNA Genome of an Early Modern Human from Kostenki, Russia
Published in Current biology (09-02-2010)“…The recovery of DNA sequences from early modern humans (EMHs) could shed light on their interactions with archaic groups such as Neandertals and their…”
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7
Mitochondrial genomes reveal an explosive radiation of extinct and extant bears near the Miocene-Pliocene boundary
Published in BMC evolutionary biology (28-07-2008)“…Despite being one of the most studied families within the Carnivora, the phylogenetic relationships among the members of the bear family (Ursidae) have long…”
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8
Engineering and optimising deaminase fusions for genome editing
Published in Nature communications (02-11-2016)“…Precise editing is essential for biomedical research and gene therapy. Yet, homology-directed genome modification is limited by the requirements for genomic…”
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9
Patterns of Damage in Genomic DNA Sequences from a Neandertal
Published in Proceedings of the National Academy of Sciences - PNAS (11-09-2007)“…High-throughput direct sequencing techniques have recently opened the possibility to sequence genomes from Pleistocene organisms. Here we analyze DNA sequences…”
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10
Single T Cell Sequencing Demonstrates the Functional Role of αβ TCR Pairing in Cell Lineage and Antigen Specificity
Published in Frontiers in immunology (31-07-2019)“…Although structural studies of individual T cell receptors (TCRs) have revealed important roles for both the α and β chain in directing MHC and antigen…”
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11
Targeted Retrieval and Analysis of Five Neandertal mtDNA Genomes
Published in Science (American Association for the Advancement of Science) (17-07-2009)“…Analysis of Neandertal DNA holds great potential for investigating the population history of this group of hominins, but progress has been limited due to the…”
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12
Massively parallel sequencing of single cells by epicPCR links functional genes with phylogenetic markers
Published in The ISME Journal (01-02-2016)“…Many microbial communities are characterized by high genetic diversity. 16S ribosomal RNA sequencing can determine community members, and metagenomics can…”
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13
Analysis of one million base pairs of Neanderthal DNA
Published in Nature (16-11-2006)“…Neanderthals are the extinct hominid group most closely related to contemporary humans, so their genome offers a unique opportunity to identify genetic changes…”
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14
A Model of Somatic Hypermutation Targeting in Mice Based on High-Throughput Ig Sequencing Data
Published in The Journal of immunology (1950) (01-11-2016)“…Analyses of somatic hypermutation (SHM) patterns in B cell Ig sequences have important basic science and clinical applications, but they are often confounded…”
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15
The Neandertal genome and ancient DNA authenticity
Published in The EMBO journal (02-09-2009)“…Recent advances in high‐thoughput DNA sequencing have made genome‐scale analyses of genomes of extinct organisms possible. With these new opportunities come…”
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Targeted Investigation of the Neandertal Genome by Array-Based Sequence Capture
Published in Science (American Association for the Advancement of Science) (07-05-2010)“…It is now possible to perform whole-genome shotgun sequencing as well as capture of specific genomic regions for extinct organisms. However, targeted…”
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17
Road blocks on paleogenomes--polymerase extension profiling reveals the frequency of blocking lesions in ancient DNA
Published in Nucleic acids research (01-09-2010)“…Although the last few years have seen great progress in DNA sequence retrieval from fossil specimens, some of the characteristics of ancient DNA remain poorly…”
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18
Stable gene targeting in human cells using single-strand oligonucleotides with modified bases
Published in PloS one (14-05-2012)“…Recent advances allow multiplexed genome engineering in E. coli, employing easily designed oligonucleotides to edit multiple loci simultaneously. A similar…”
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19
Neutralizing antibodies against West Nile virus identified directly from human B cells by single-cell analysis and next generation sequencing
Published in Integrative biology (Cambridge) (01-12-2015)“…West Nile virus (WNV) infection is an emerging mosquito-borne disease that can lead to severe neurological illness and currently has no available treatment or…”
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20
A High-Coverage Genome Sequence from an Archaic Denisovan Individual
Published in Science (American Association for the Advancement of Science) (12-10-2012)“…We present a DNA library preparation method that has allowed us to reconstruct a high-coverage (30×) genome sequence of a Denisovan, an extinct relative of…”
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