Search Results - "Briggs, Adrian"

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    Optimization of scarless human stem cell genome editing by Yang, Luhan, Guell, Marc, Byrne, Susan, Yang, Joyce L, De Los Angeles, Alejandro, Mali, Prashant, Aach, John, Kim-Kiselak, Caroline, Briggs, Adrian W, Rios, Xavier, Huang, Po-Yi, Daley, George, Church, George

    Published in Nucleic acids research (01-10-2013)
    “…Efficient strategies for precise genome editing in human-induced pluripotent cells (hiPSCs) will enable sophisticated genome engineering for research and…”
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    Removal of deaminated cytosines and detection of in vivo methylation in ancient DNA by Briggs, Adrian W, Stenzel, Udo, Meyer, Matthias, Krause, Johannes, Kircher, Martin, Pääbo, Svante

    Published in Nucleic acids research (01-04-2010)
    “…DNA sequences determined from ancient organisms have high error rates, primarily due to uracil bases created by cytosine deamination. We use synthetic…”
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    Hierarchical Clustering Can Identify B Cell Clones with High Confidence in Ig Repertoire Sequencing Data by Gupta, Namita T, Adams, Kristofor D, Briggs, Adrian W, Timberlake, Sonia C, Vigneault, Francois, Kleinstein, Steven H

    Published in The Journal of immunology (1950) (15-03-2017)
    “…Adaptive immunity is driven by the expansion, somatic hypermutation, and selection of B cell clones. Each clone is the progeny of a single B cell responding to…”
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    Iterative capped assembly: rapid and scalable synthesis of repeat-module DNA such as TAL effectors from individual monomers by Briggs, Adrian W, Rios, Xavier, Chari, Raj, Yang, Luhan, Zhang, Feng, Mali, Prashant, Church, George M

    Published in Nucleic acids research (01-08-2012)
    “…DNA built from modular repeats presents a challenge for gene synthesis. We present a solid surface-based sequential ligation approach, which we refer to as…”
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    A Complete mtDNA Genome of an Early Modern Human from Kostenki, Russia by Krause, Johannes, Briggs, Adrian W., Kircher, Martin, Maricic, Tomislav, Zwyns, Nicolas, Derevianko, Anatoli, Pääbo, Svante

    Published in Current biology (09-02-2010)
    “…The recovery of DNA sequences from early modern humans (EMHs) could shed light on their interactions with archaic groups such as Neandertals and their…”
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    Engineering and optimising deaminase fusions for genome editing by Yang, Luhan, Briggs, Adrian W., Chew, Wei Leong, Mali, Prashant, Guell, Marc, Aach, John, Goodman, Daniel Bryan, Cox, David, Kan, Yinan, Lesha, Emal, Soundararajan, Venkataramanan, Zhang, Feng, Church, George

    Published in Nature communications (02-11-2016)
    “…Precise editing is essential for biomedical research and gene therapy. Yet, homology-directed genome modification is limited by the requirements for genomic…”
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    Patterns of Damage in Genomic DNA Sequences from a Neandertal by Briggs, Adrian W., Stenzel, Udo, Johnson, Philip L. F., Green, Richard E., Kelso, Janet, Prüfer, Kay, Meyer, Matthias, Krause, Johannes, Ronan, Michael T., Lachmann, Michael, Pääbo, Svante

    “…High-throughput direct sequencing techniques have recently opened the possibility to sequence genomes from Pleistocene organisms. Here we analyze DNA sequences…”
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    Single T Cell Sequencing Demonstrates the Functional Role of αβ TCR Pairing in Cell Lineage and Antigen Specificity by Carter, Jason A, Preall, Jonathan B, Grigaityte, Kristina, Goldfless, Stephen J, Jeffery, Eric, Briggs, Adrian W, Vigneault, Francois, Atwal, Gurinder S

    Published in Frontiers in immunology (31-07-2019)
    “…Although structural studies of individual T cell receptors (TCRs) have revealed important roles for both the α and β chain in directing MHC and antigen…”
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    Massively parallel sequencing of single cells by epicPCR links functional genes with phylogenetic markers by Spencer, Sarah J, Tamminen, Manu V, Preheim, Sarah P, Guo, Mira T, Briggs, Adrian W, Brito, Ilana L, A Weitz, David, Pitkänen, Leena K, Vigneault, Francois, Virta, Marko PJuhani, Alm, Eric J

    Published in The ISME Journal (01-02-2016)
    “…Many microbial communities are characterized by high genetic diversity. 16S ribosomal RNA sequencing can determine community members, and metagenomics can…”
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    Analysis of one million base pairs of Neanderthal DNA by Ronan, Michael T, Egholm, Michael, Paunovic, Maja, Pääbo, Svante, Green, Richard E, Ptak, Susan E, Rothberg, Jonathan M, Briggs, Adrian W, Simons, Jan F, Krause, Johannes, Du, Lei

    Published in Nature (16-11-2006)
    “…Neanderthals are the extinct hominid group most closely related to contemporary humans, so their genome offers a unique opportunity to identify genetic changes…”
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    A Model of Somatic Hypermutation Targeting in Mice Based on High-Throughput Ig Sequencing Data by Cui, Ang, Di Niro, Roberto, Vander Heiden, Jason A, Briggs, Adrian W, Adams, Kris, Gilbert, Tamara, O'Connor, Kevin C, Vigneault, Francois, Shlomchik, Mark J, Kleinstein, Steven H

    Published in The Journal of immunology (1950) (01-11-2016)
    “…Analyses of somatic hypermutation (SHM) patterns in B cell Ig sequences have important basic science and clinical applications, but they are often confounded…”
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    The Neandertal genome and ancient DNA authenticity by Green, Richard E, Briggs, Adrian W, Krause, Johannes, Prüfer, Kay, Burbano, Hernán A, Siebauer, Michael, Lachmann, Michael, Pääbo, Svante

    Published in The EMBO journal (02-09-2009)
    “…Recent advances in high‐thoughput DNA sequencing have made genome‐scale analyses of genomes of extinct organisms possible. With these new opportunities come…”
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    Road blocks on paleogenomes--polymerase extension profiling reveals the frequency of blocking lesions in ancient DNA by Heyn, Patricia, Stenzel, Udo, Briggs, Adrian W, Kircher, Martin, Hofreiter, Michael, Meyer, Matthias

    Published in Nucleic acids research (01-09-2010)
    “…Although the last few years have seen great progress in DNA sequence retrieval from fossil specimens, some of the characteristics of ancient DNA remain poorly…”
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    Stable gene targeting in human cells using single-strand oligonucleotides with modified bases by Rios, Xavier, Briggs, Adrian W, Christodoulou, Danos, Gorham, Josh M, Seidman, Jonathan G, Church, George M

    Published in PloS one (14-05-2012)
    “…Recent advances allow multiplexed genome engineering in E. coli, employing easily designed oligonucleotides to edit multiple loci simultaneously. A similar…”
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