Search Results - "Briffa, Jessica"

Heavy metal pollution in the environment and their toxicological effects on humans by Briffa, Jessica, Sinagra, Emmanuel, Blundell, Renald

“…Environmental pollution of heavy metals is increasingly becoming a problem and has become of great concern due to the adverse effects it is causing around the…”
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Leptin in pregnancy and development: a contributor to adulthood disease? by Briffa, Jessica F, McAinch, Andrew J, Romano, Tania, Wlodek, Mary E, Hryciw, Deanne H

“…Emerging research has highlighted the importance of leptin in fetal growth and development independent of its essential role in the maintenance of hunger and…”
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Transgenerational programming of nephron deficits and hypertension by Briffa, Jessica F., Wlodek, Mary E., Moritz, Karen M.

“…Exposure to a sub-optimal environment in the womb can result in poor fetal growth and impair the normal development of organs. The kidney, specifically the…”
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Adipokines as a link between obesity and chronic kidney disease by Briffa, Jessica F, McAinch, Andrew J, Poronnik, Philip, Hryciw, Deanne H

“…Adipocytes secrete a number of bioactive adipokines that activate a variety of cell signaling pathways in central and peripheral tissues. Obesity is associated…”
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Fins, fur, and wings: the study of Tmem161b across species, and what it tells us about its function in the heart by Smith, Kelly A., Dominado, Nicole, Briffa, Jessica F.

“…Transmembrane protein 161b (Tmem161b) was recently identified in multiple high-through-put phenotypic screens, including in fly, zebrafish, and mouse. In…”
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Imprinted gene alterations in the kidneys of growth restricted offspring may be mediated by a long non-coding RNA by Doan, Thu N A, Cowley, James M, Phillips, Aaron L, Briffa, Jessica F, Leemaqz, Shalem Y, Burton, Rachel A, Romano, Tania, Wlodek, Mary E, Bianco-Miotto, Tina

“…Altered epigenetic mechanisms have been previously reported in growth restricted offspring whose mothers experienced environmental insults during pregnancy in…”
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Exercise alters cardiovascular and renal pregnancy adaptations in female rats born small on a high-fat diet by Mahizir, Dayana, Briffa, Jessica F, Anevska, Kristina, Wadley, Glenn D, Moritz, Karen M, Wlodek, Mary E

“…Intrauterine growth restriction programs adult cardiorenal disease, which may be exacerbated by pregnancy and obesity. Importantly, exercise has positive…”
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Exercise initiated during pregnancy in rats born growth restricted alters placental mTOR and nutrient transporter expression by Mangwiro, Yeukai T. M., Cuffe, James S. M., Mahizir, Dayana, Anevska, Kristina, Gravina, Sogand, Romano, Tania, Moritz, Karen M., Briffa, Jessica F., Wlodek, Mary E.

“…Key points Fetal growth is dependent on effective placental nutrient transportation, which is regulated by mammalian target of rapamycin (mTOR) complex 1…”
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Exercise improves metabolic function and alters the microbiome in rats with gestational diabetes by Mahizir, Dayana, Briffa, Jessica F., Wood, Jennifer L., Anevska, Kristina, Hill‐Yardin, Elisa L., Jefferies, Andrew J., Gravina, Sogand, Mazzarino, Gisella, Franks, Ashley E., Moritz, Karen M., Wadley, Glenn D., Wlodek, Mary E.

“…Gestational diabetes mellitus (GDM) is a common pregnancy complication, particularly prevalent in obese women. Importantly, exercise has beneficial impacts on…”
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Maternal exercise in rats upregulates the placental insulin‐like growth factor system with diet‐ and sex‐specific responses: minimal effects in mothers born growth restricted by Mangwiro, Yeukai T. M., Cuffe, James S. M., Briffa, Jessica F., Mahizir, Dayana, Anevska, Kristina, Jefferies, Andrew J., Hosseini, Sogand, Romano, Tania, Moritz, Karen M., Wlodek, Mary E.

“…Key points The placental insulin‐like growth factor (IGF) system is critical for normal fetoplacental growth, which is dysregulated following several pregnancy…”
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Uteroplacental insufficiency reduces rat plasma leptin concentrations and alters placental leptin transporters: ameliorated with enhanced milk intake and nutrition by Briffa, Jessica F., O'Dowd, Rachael, Moritz, Karen M., Romano, Tania, Jedwab, Lisa R., McAinch, Andrew J., Hryciw, Deanne H., Wlodek, Mary E.

“…Key points Uteroplacental insufficiency compromises maternal mammary development, milk production and pup organ development; this is ameliorated by…”
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Elevated Circulating and Placental SPINT2 Is Associated with Placental Dysfunction by Murphy, Ciara N., Walker, Susan P., MacDonald, Teresa M., Keenan, Emerson, Hannan, Natalie J., Wlodek, Mary E., Myers, Jenny, Briffa, Jessica F., Romano, Tania, Roddy Mitchell, Alexandra, Whigham, Carole-Anne, Cannon, Ping, Nguyen, Tuong-Vi, Kandel, Manju, Pritchard, Natasha, Tong, Stephen, Kaitu’u-Lino, Tu’uhevaha J.

“…Biomarkers for placental dysfunction are currently lacking. We recently identified SPINT1 as a novel biomarker; SPINT2 is a functionally related placental…”
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Maternal growth restriction and stress exposure in rats differentially alters expression of components of the placental glucocorticoid barrier and nutrient transporters by Briffa, Jessica F., Hosseini, Sogand S., Tran, Melanie, Moritz, Karen M., Cuffe, James S.M., Wlodek, Mary E.

“…The placenta plays a major role in the development of fetal growth restriction, which affects 10% of pregnancies and contributes to chronic adult disease risk…”
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Short term exposure to elevated levels of leptin reduces proximal tubule cell metabolic activity by Briffa, Jessica F., Grinfeld, Esther, McAinch, Andrew J., Poronnik, Philip, Hryciw, Deanne H.

“…•The acute effects of leptin on the proximal tubule cells (PTC) are unknown.•p44/42 MAPK and mTOR were activated at 0.10, 0.25 and 0.50μg/ml of leptin.•Leptin…”
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Treadmill Exercise before and during Pregnancy Improves Bone Deficits in Pregnant Growth Restricted Rats without the Exacerbated Effects of High Fat Diet by Anevska, Kristina, Mahizir, Dayana, Briffa, Jessica F, Jefferies, Andrew J, Wark, John D, Grills, Brian L, Brady, Rhys D, McDonald, Stuart J, Wlodek, Mary E, Romano, Tania

“…Growth restriction programs adult bone deficits and increases the risk of obesity, which may be exacerbated during pregnancy. We aimed to determine if high-fat…”
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Maternal exercise alters rat fetoplacental stress response: Minimal effects of maternal growth restriction and high-fat feeding by Mangwiro, Yeukai TM, Cuffe, James SM, Vickers, Mark H., Reynolds, Clare M., Mahizir, Dayana, Anevska, Kristina, Gravina, Sogand, Romano, Tania, Moritz, Karen M., Briffa, Jessica F., Wlodek, Mary E.

“…Fetal growth restriction complicates 10% of pregnancies and increases offspring (F1) risk of metabolic disorders, including obesity and gestational diabetes…”
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Uptake of leptin and albumin via separate pathways in proximal tubule cells by Briffa, Jessica F., Grinfeld, Esther, Poronnik, Philip, McAinch, Andrew J., Hryciw, Deanne H.

“…[Display omitted] The adipokine leptin and oncotic protein albumin are endocytosed in the proximal tubule via the scavenger receptor megalin. Leptin reduces…”
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Reducing Pup Litter Size Alters Early Postnatal Calcium Homeostasis and Programs Adverse Adult Cardiovascular and Bone Health in Male Rats by Briffa, Jessica F, O'Dowd, Rachael, Romano, Tania, Muhlhausler, Beverly S, Moritz, Karen M, Wlodek, Mary E

“…The in utero and early postnatal environments play essential roles in offspring growth and development. Standardizing or reducing pup litter size can…”
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Acute leptin exposure reduces megalin expression and upregulates TGFβ1 in cultured renal proximal tubule cells by Briffa, Jessica F., Grinfeld, Esther, Mathai, Michael L., Poronnik, Phillip, McAinch, Andrew J., Hryciw, Deanne H.

“…•Opossum kidney proximal tubule cells express leptin protein endogenously.•Acute leptin exposure upregulates AMPK and fibrotic mediator expression.•Acute…”
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Maternal exercise and growth restriction in rats alters placental angiogenic factors and blood space area in a sex-specific manner by Mangwiro, Yeukai TM, Briffa, Jessica F., Gravina, Sogand, Mahizir, Dayana, Anevska, Kristina, Romano, Tania, Moritz, Karen M., Cuffe, James SM, Wlodek, Mary E.

“…Fetal growth and development are dependent on adequate placental nutrient transfer. The surface area of the placental villous network is a key determinant of…”
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