Search Results - "Brieva, Jose A."

STAT-3 activation by differential cytokines is critical for human in vivo-generated plasma cell survival and Ig secretion by Rodríguez-Bayona, Beatriz, Ramos-Amaya, Ana, López-Blanco, Rubén, Campos-Caro, Antonio, Brieva, José A

“…Maturation and survival of plasma cells (PCs) depends on extrinsic factors provided in specialized niches. In addition, B lymphocyte differentiation into PCs…”
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The transcriptional profiling of human in vivo-generated plasma cells identifies selective imbalances in monoclonal gammopathies by Valor, Luis M, Rodríguez-Bayona, Beatriz, Ramos-Amaya, Ana B, Brieva, José A, Campos-Caro, Antonio

“…Plasma cells (PC) represent the heterogeneous final stage of the B cells (BC) differentiation process. To characterize the transition of BC into PC,…”
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Macrophage Migration Inhibitory Factor Promotes Intestinal Tumorigenesis by Wilson, Jonathan M., Coletta, P. Louise, Cuthbert, Richard J., Scott, Nigel, MacLennan, Kenneth, Hawcroft, Gillian, Leng, Lin, Lubetsky, Jodi B., Jin, Kai K., Lolis, Elias, Medina, Francisco, Brieva, Jose A., Poulsom, Richard, Markham, Alexander F., Bucala, Richard, Hull, Mark A.

“…Background & Aims: The cytokine macrophage migration inhibitory factor (MIF) is expressed throughout the human gastrointestinal tract. Recently, protumorigenic…”
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Inorganic polyphosphate and specific induction of apoptosis in human plasma cells by Hernandez-Ruiz, L, Gonzalez-Garcia, I, Castro, C, Brieva, JA, Ruiz, FA

“…Unidad de Investigacion, Hospital Universitario Puerta del Mar, Cadiz, Spain. BACKGROUND AND OBJECTIVES: Inorganic polyphosphate (polyP), a ubiquitous…”
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Transcription of PRDM1, the master regulator for plasma cell differentiation, depends on an SP1/SP3/EGR-1 GC-box by Mora-López, Francisco, Pedreño-Horrillo, Nuria, Delgado-Pérez, Luis, Brieva, José A, Campos-Caro, Antonio

“…The positive regulatory domain containing 1, encoded by the PRDM1 gene, is a transcriptional repressor considered as a master regulator that is required and…”
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Higher maturity and connective tissue association distinguish resident from recently generated human tonsil plasma cells by Francisco Medina, Carmen Segundo, Gema Jiménez-Gómez, Inés González-García, Antonio Campos-Caro, José A. Brieva

“…Human plasma cells (PC) are present in cell suspensions obtained from the tonsil by mechanical disaggregation (PC(MECH)). The present study shows that a…”
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Decreased frequency and activated phenotype of blood CD27 IgD IgM B lymphocytes is a permanent abnormality in systemic lupus erythematosus patients by Rodríguez-Bayona, Beatriz, Ramos-Amaya, Ana, Pérez-Venegas, José J, Rodríguez, Carmen, Brieva, José A

“…Systemic lupus erythematosus (SLE) is characterized by B cell hyper-activation and auto-reactivity resulting in pathogenic auto-antibody generation. The…”
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Clinical relevance of circulating anti‐ENA and anti‐dsDNA secreting cells from SLE patients and their dependence on STAT‐3 activation by de la Varga Martínez, Raquel, Rodríguez‐Bayona, Beatriz, Añez, Gustavo A., Medina Varo, Fermín, Pérez Venegas, José J., Brieva, José A., Rodríguez, Carmen

“…Disturbances of plasma cell homeostasis and auto‐antibody production are hallmarks of systemic lupus erythematosus. The aim of this study was to explore the…”
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Cutting edge: IL-21 derived from human follicular helper T cells acts as a survival factor for secondary lymphoid organ, but not for bone marrow, plasma cells by Rodríguez-Bayona, Beatriz, Ramos-Amaya, Ana, Bernal, Jesús, Campos-Caro, Antonio, Brieva, José A

“…IL-21 induces the differentiation of activated B lymphocytes into plasma cells (PC), but its direct effect on PC remains uncertain. This study analyzes the…”
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The heterogeneity shown by human plasma cells from tonsil, blood, and bone marrow reveals graded stages of increasing maturity, but local profiles of adhesion molecule expression by Medina, Francisco, Segundo, Carmen, Campos-Caro, Antonio, González-Garcı́a, Inés, Brieva, José A.

“…Plasma cells (PCs) are the final B-cell differentiation stage. Recent evidence reveals relevant functional differences within the PC compartment. In rodents,…”
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Survival of human circulating antigen-induced plasma cells is supported by plasma cell-niche cytokines and T follicular helper lymphocytes by Ramos-Amaya, Ana, Rodríguez-Bayona, Beatriz, López-Blanco, Rubén, Andújar, Eloisa, Pérez-Alegre, Mónica, Campos-Caro, Antonio, Brieva, José A

“…Human circulating Ag-induced plasma cells (PCs) contain a high proportion of cycling cells. This study reveals that these PCs spontaneously proliferate in…”
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Syntaxin-4 is implicated in the secretion of antibodies by human plasma cells by Gómez‐Jaramillo, Laura, Delgado‐Pérez, Luis, Reales, Elena, Mora‐López, Francisco, Mateos, Rosa M., García‐Poley, Antonio, Brieva, José A., Campos‐Caro, Antonio

“…The functional role of SNAP23, STX3, and STX4 in Ab secretion; SNAP23, STX4 is implicated in the Ab secretion by a myeloma cell line and by normal human colon…”
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Immunization-Induced Perturbation of Human Blood Plasma Cell Pool: Progressive Maturation, IL-6 Responsiveness, and High PRDI-BF1/BLIMP1 Expression Are Critical Distinctions between Antigen-Specific and Nonspecific Plasma Cells by Gonzalez-Garcia, Ines, Ocana, Esther, Jimenez-Gomez, Gema, Campos-Caro, Antonio, Brieva, Jose A

“…The present study shows that reimmunization with tetanus toxoid (tet) caused a transient increase of the human blood plasma cell (PC) pool, detectable from 6th…”
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Differential expression of SLAMS and other modulatory molecules by human plasma cells during normal maturation by Rodríguez-Bayona, Beatriz, Ramos-Amaya, Ana, Brieva, José A

“…Abstract Plasma cells (PCs) are specialized in antibody (Ab) production and they are, therefore, responsible for maintaining humoral immune responses. The…”
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Human BSAP and BLIMP1 conform an autoregulatory feedback loop by Mora-López, Francisco, Reales, Elena, Brieva, José A., Campos-Caro, Antonio

“…B-lymphocyte–induced maturation protein-1 (BLIMP1), encoded by the PRDM1 gene, is a transcriptional repressor considered a master regulator that is required…”
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The prognostic role of CXCR3 expression by chronic lymphocytic leukemia B cells by Ocana, Esther, Delgado-Perez, Luis, Campos-Caro, Antonio, Munoz, Juan, Paz, Antonio, Franco, Rafael, Brieva, Jose A

“…Servicio de Inmunología and Unidad de Investigación (EO, LD-P, AC-C, JAB); Servicio de Hematología, Hospital Universitario Puerta del Mar, Cádiz, Spain (JM);…”
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Identification of Soluble N-Ethylmaleimide-Sensitive Factor Attachment Protein Receptor Exocytotic Machinery in Human Plasma Cells: SNAP-23 Is Essential for Antibody Secretion by Reales, Elena, Mora-Lopez, Francisco, Rivas, Veronica, Garcia-Poley, Antonio, Brieva, Jose A, Campos-Caro, Antonio

“…Plasma cells (PC) are B-lymphocytes terminally differentiated in a postmitotic state, with the unique purpose of manufacturing and exporting Igs. Despite the…”
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Increased survival is a selective feature of human circulating antigen-induced plasma cells synthesizing high-affinity antibodies by González-García, Inés, Rodríguez-Bayona, Beatriz, Mora-López, Francisco, Campos-Caro, Antonio, Brieva, José A.

“…The present study shows that tetanus toxoid (tet) booster releases to the human circulation 2 subsets of specific plasma cells (PCs), as defined by phenotype…”
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Identification of overexpressed genes in frequently gained/amplified chromosome regions in multiple myeloma by Largo, C, Alvarez, S, Saez, B, Blesa, D, Martin-Subero, JI, Gonzalez-Garcia, I, Brieva, JA, Dopazo, J, Siebert, R, Calasanz, MJ, Cigudosa, JC

“…Cytogenetics Unit, Spanish National Cancer Centre, (CNIO), C/ Melchor Fernandez Almagro 3, Madrid, 28029, Spain. BACKGROUND AND OBJECTIVES: Multiple myeloma…”
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Chemokine receptor expression on infiltrating lymphocytes from abdominal aortic aneurysms: Role of CXCR4–CXCL12 in lymphoid recruitment by Ocaña, Esther, Pérez-Requena, José, Bohórquez, Juan-Carlos, Brieva, José A, Rodríguez, Carmen

“…Abstract This is a study to define the profile of chemokine receptors expressed on isolated infiltrating lymphocytes in human abdominal aortic aneurysms…”
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