Search Results - "Bridges, R.J"

WS1.3 Enhanced correction of F508del CFTR using drug-like small molecules in combination with correctors and potentiators by Miller, J.P, Drew, L, Green, O, Villella, A, Bastos, C, Munoz, B, Cullen, M.D, Hauck, S, Wachi, S, Giuliano, K, Longo, K.A, Roskelley, E, Dobbs, W, Garza, D, Haeberlein, M, Weiner, D, Bridges, R.J, Thakerar, A, Hutt, D.M, Balch, W.E, Tait, B.D

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System Xc− Antiporter Inhibitors: Azo-Linked Amino-Naphthyl-Sulfonate Analogues of Sulfasalazine by Nehser, M., Dark, J., Schweitzer, D., Campbell, M., Zwicker, J., Hitt, D. M., Little, H., Diaz-Correa, A., Holley, D. C., Patel, S. A., Thompson, C. M., Bridges, R. J.

“…The cystine/glutamate antiporter system x c − (S x c − ) mediates the exchange of intracellular l -glutamate ( l -Glu) with extracellular l -cystine ( l -Cys 2…”
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Novel di-aryl-substituted isoxazoles act as noncompetitive inhibitors of the system x c - cystine/glutamate exchanger by Newell, J.L., Keyari, C.M., McDaniel, S.W., Diaz, P.J., Natale, N.R., Patel, S.A., Bridges, R.J.

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Autoradiographic characterization of putative excitatory amino acid transport sites by Anderson, K J, Monaghan, D T, Bridges, R J, Tavoularis, A L, Cotman, C W

“…Removal of excitatory amino acids from the extracellular space is now postulated to occur through at least two distinct transport systems that are…”
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Novel di-aryl-substituted isoxazoles act as noncompetitive inhibitors of the system xc- cystine/glutamate exchanger by Newell, J.L., Keyari, C.M., McDaniel, S.W., Diaz, P.J., Natale, N.R., Patel, S.A., Bridges, R.J.

“…•Potent isoxazole-based noncompetitive inhibitors were developed for system xc-.•Mechanism of inhibition is dependent upon the placement of lipophilic aryl…”
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Pharmacology of CFTR Chloride Channel Activity by SCHULTZ, B. D, SINGH, A. K, DEVOR, D. C, BRIDGES, R. J

“…B. D. SCHULTZ , A. K. SINGH , D. C. DEVOR , AND R. J. BRIDGES University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania Schultz, B. D., A. K…”
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Methods for Detecting Internalized, FM 1-43 Stained Particles in Epithelial Cells and Monolayers by Bertrand, C.A., Laboisse, C., Hopfer, U., Bridges, R.J., Frizzell, R.A.

“…The membrane dye FM 1-43 has frequently been used to quantify exocytosis in neurons. In epithelia, intense lateral intracellular space staining and…”
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Rescue of Dysfunctional ΔF508-CFTR Chloride Channel Activity by IBMX by Schultz, B.D., Frizzell, R.A., Bridges, R.J.

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Biochemical and biophysical identification of cystic fibrosis transmembrane conductance regulator chloride channels as components of endocytic clathrin-coated vesicles by BRADBURY, N. A, COHN, J. A, VENGLARIK, C. J, BRIDGES, R. J

“…Cystic fibrosis results from mutations in the gene encoding the CFTR Cl- channel. Although CFTR occurs as an integral component of the plasma membrane, recent…”
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Substituted quinolines as inhibitors of l-glutamate transport into synaptic vesicles by Bartlett, R.D., Esslinger, C.S., Thompson, C.M., Bridges, R.J.

“…This study investigated the structure–activity relationships and kinetic properties of a library of kynurenate analogues as inhibitors of 3H- l-glutamate…”
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Failure of cholesterol-lowering by psyllium by Van Rosendaal, G.M.A, Shaffer, E.A, Brant, R, Bridges, R.J, Edwards, A.L

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A simple assay for agonist-regulated Cl and K conductances in salt-secreting epithelial cells by Venglarik, C J, Bridges, R J, Frizzell, R A

“…We developed a convenient flux assay that permits simultaneous measurement of Cl and K conductance pathways in Cl-secreting epithelial cells. Monolayers of the…”
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Tolbutamide causes open channel blockade of cystic fibrosis transmembrane conductance regulator Cl- channels by Venglarik, C.J., Schultz, B.D., DeRoos, A.D., Singh, A.K., Bridges, R.J.

“…Cystic fibrosis transmembrane conductance regulator (CFTR) is an epithelial Cl- channel that is regulated by protein kinase A and cytosolic nucleotides…”
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Failure of cholesterol-lowering by psyllium by Rosendaal, G.M.A., Shaffer, E.A., Brant, R., Bridges, R.J., Edwards, A.L.

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Lack of conventional ATPase properties in CFTR chloride channel gating by Schultz, B D, Bridges, R J, Frizzell, R A

“…CFTR shares structural homology with the ABC transporter superfamily of proteins which hydrolyze ATP to effect the transport of compounds across cell…”
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Psoralens: novel modulators of Cl- secretion by Devor, D.C. (University of Pittsburgh, Pittsburgh, PA.), Singh, A.K, Bridges, R.J, Frizzell, R.A

“…We evaluated effects of psoralens on Cl- secretion (short-circuit current, Isc) across T84 monolayers. Methoxsalen failed to increase Isc. Several observations…”
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Gliotoxic actions of excitatory amino acids by Bridges, R J, Hatalski, C G, Shim, S N, Cummings, B J, Vijayan, V, Kundi, A, Cotman, C W

“…Cultures of neonatal Type I astrocytes of the rat were exposed to a series of excitatory amino acid analogs to identify those compounds that were gliotoxic. In…”
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Neuronally mediated and direct effects of prostaglandins on ion transport in rat colon descendens by DIENER, M, BRIDGES, R. J, KNOBLOCH, S. F, RUMMEL, W

“…Two preparations of rat colon descendens were used in order to localize the action sites of iloprost and prostaglandin E2 (PGE2). One preparation, the…”
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L-trans-2,3-Pyrrolidine Dicarboxylate: Characterization of a Novel Excitotoxin by WILLIS, C.L, HUMPHREY, J.M, KOCH, H.P, HART, J.A, BLAKELY, T, RALSTON, L, BAKER, C.A, SHIM, S, KADRI, M, CHAMBERLIN, A.R, BRIDGES, R.J

“…This study investigated the in vitro and in vivo excitotoxic properties of a novel conformationally constrained analogue of L- trans-2,3-pyrrolidine…”
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Apical Membrane Isolation of Surface and Crypt Cells from Rabbit Distal Colon by Abrahamse, S.L., Bridges, R.J., De Jong, M.D., Bindels, R.J.M., Van Os, C.H.

“…Surface and crypt cells of rabbit distal colon were separately isolated, and amiloride-sensitive22Na+uptake could only be demonstrated in a crude membrane…”
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