Search Results - "Bridgeman, John"

A fluorescence-based assessment of the fate of organic matter in water treated using crude/purified Hibiscus seeds as coagulant in drinking water treatment by Jones, Alfred Ndahi, Bridgeman, John

“…This study used fluorescence excitation-emission matrices (EEMs) analysis to investigate the characteristics of natural organic matter (NOM) in treated water…”
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A Molecular Basis for the Control of Preimmune Escape Variants by HIV-Specific CD8+ T Cells by Ladell, Kristin, Hashimoto, Masao, Iglesias, Maria Candela, Wilmann, Pascal G., McLaren, James E., Gras, Stéphanie, Chikata, Takayuki, Kuse, Nozomi, Fastenackels, Solène, Gostick, Emma, Bridgeman, John S., Venturi, Vanessa, Arkoub, Zaïna Aït, Agut, Henri, van Bockel, David J., Almeida, Jorge R., Douek, Daniel C., Meyer, Laurence, Venet, Alain, Takiguchi, Masafumi, Rossjohn, Jamie, Price, David A., Appay, Victor

“…The capacity of the immune system to adapt to rapidly evolving viruses is a primary feature of effective immunity, yet its molecular basis is unclear. Here, we…”
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Changes in global groundwater organic carbon driven by climate change and urbanization by McDonough, Liza K., Santos, Isaac R., Andersen, Martin S., O’Carroll, Denis M., Rutlidge, Helen, Meredith, Karina, Oudone, Phetdala, Bridgeman, John, Gooddy, Daren C., Sorensen, James P. R., Lapworth, Dan J., MacDonald, Alan M., Ward, Jade, Baker, Andy

“…Climate change and urbanization can increase pressures on groundwater resources, but little is known about how groundwater quality will change. Here, we use a…”
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Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination by Pageon, Sophie V., Tabarin, Thibault, Yamamoto, Yui, Ma, Yuanqing, Nicovich, Philip R., Bridgeman, John S., Cohnen, André, Benzing, Carola, Gao, Yijun, Crowther, Michael D., Tungatt, Katie, Dolton, Garry, Sewell, Andrew K., Price, David A., Acuto, Oreste, Parton, Robert G., Gooding, J. Justin, Rossy, Jérémie, Rossjohn, Jamie, Gaus, Katharina

“…Antigen recognition by the T-cell receptor (TCR) is a hallmark of the adaptive immune system. When the TCR engages a peptide bound to the restricting major…”
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Building better chimeric antigen receptors for adoptive T cell therapy by Bridgeman, John S, Hawkins, Robert E, Hombach, Andreas A, Abken, Hinrich, Gilham, David E

“…The last few years have seen the transfer of two decades of research into Chimeric Antigen Receptors (CARs) into clinical trials. Despite this extensive…”
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Relating freshwater organic matter fluorescence to organic carbon removal efficiency in drinking water treatment by Bieroza, Magdalena, Baker, Andy, Bridgeman, John

“…Monthly raw and clarified water samples were obtained for 16 UK surface water treatment works. The fluorescence excitation–emission matrix (EEM) technique was…”
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Massively parallel interrogation and mining of natively paired human TCRαβ repertoires by Spindler, Matthew J., Nelson, Ayla L., Wagner, Ellen K., Oppermans, Natasha, Bridgeman, John S., Heather, James M., Adler, Adam S., Asensio, Michael A., Edgar, Robert C., Lim, Yoong Wearn, Meyer, Everett H., Hawkins, Robert E., Cobbold, Mark, Johnson, David S.

“…T cells engineered to express antigen-specific T cell receptors (TCRs) are potent therapies for viral infections and cancer. However, efficient identification…”
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CD1b-restricted GEM T cell responses are modulated by Mycobacterium tuberculosis mycolic acid meromycolate chains by Chancellor, Andrew, Tocheva, Anna S., Cave-Ayland, Chris, Tezera, Liku, White, Andrew, Dulayymi, Juma’a R. Al, Bridgeman, John S., Tews, Ivo, Wilson, Susan, Lissin, Nikolai M., Tebruegge, Marc, Marshall, Ben, Sharpe, Sally, Elliott, Tim, Skylaris, Chris-Kriton, Essex, Jonathan W., Baird, Mark S., Gadola, Stephan, Elkington, Paul, Mansour, Salah

“…Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains a major human pandemic. Germline-encoded mycolyl lipid-reactive (GEM) T cells are…”
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High-affinity CD8 variants enhance the sensitivity of pMHCI antigen recognition via low-affinity TCRs by Knezevic, Lea, Wachsmann, Tassilo L.A., Francis, Ore, Dockree, Tamsin, Bridgeman, John S., Wouters, Anne, de Wet, Ben, Cole, David K., Clement, Mathew, McLaren, James E., Gostick, Emma, Ladell, Kristin, Llewellyn-Lacey, Sian, Price, David A., van den Berg, Hugo A., Tabi, Zsuzsanna, Sessions, Richard B., Heemskerk, Mirjam H.M., Wooldridge, Linda

“…The recognition of cell surface presented peptide-Major Histocompatibility Complex Class I (pMHCI) molecules by CD8 T-cells involves cooperative binding of the…”
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CD8 coreceptor-mediated focusing can reorder the agonist hierarchy of peptide ligands recognized via the T cell receptor by Clement, Mathew, Knezevic, Lea, Dockree, Tamsin, McLaren, James E., Ladell, Kristin, Miners, Kelly L., Llewellyn-Lacey, Sian, Rubina, Anzelika, Francis, Ore, Cole, David K., Sewell, Andrew K., Bridgeman, John S., Price, David A., van den Berg, Hugo A., Wooldridge, Linda

“…CD8⁺ T cells are inherently cross-reactive and recognize numerous peptide antigens in the context of a given major histocompatibility complex class I (MHCI)…”
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Structural and biophysical determinants of αβ T‐cell antigen recognition by Bridgeman, John S., Sewell, Andrew K., Miles, John J., Price, David A., Cole, David K.

“…Summary The molecular rules that govern MHC restriction, and allow T‐cells to differentiate between peptides derived from healthy cells and those from diseased…”
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Synergistic targeting of breast cancer stem‐like cells by human γδ T cells and CD8+ T cells by Chen, Hung‐Chang, Joalland, Noémie, Bridgeman, John S, Alchami, Fouad S, Jarry, Ulrich, Khan, Mohd Wajid A, Piggott, Luke, Shanneik, Yasmin, Li, Jianqiang, Herold, Marco J, Herrmann, Thomas, Price, David A, Gallimore, Awen M, Clarkson, Richard W, Scotet, Emmanuel, Moser, Bernhard, Eberl, Matthias

“…The inherent resistance of cancer stem cells (CSCs) to existing therapies has largely hampered the development of effective treatments for advanced malignancy…”
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Signaling via a CD28/CD40 chimeric costimulatory antigen receptor (CoStAR™), targeting folate receptor alpha, enhances T cell activity and augments tumor reactivity of tumor infiltrating lymphocytes by Kalaitsidou, Milena, Moon, Owen R, Sykorova, Martina, Bao, Leyuan, Qu, Yun, Sukumaran, Sujita, Valentine, Michael, Zhou, Xingliang, Pandey, Veethika, Foos, Kay, Medvedev, Sergey, Powell, Jr, Daniel J, Udyavar, Akshata, Gschweng, Eric, Rodriguez, Ruben, Dudley, Mark E, Hawkins, Robert E, Kueberuwa, Gray, Bridgeman, John S

“…Transfer of autologous tumor infiltrating lymphocytes (TIL) to patients with refractory melanoma has shown clinical efficacy in a number of trials. However,…”
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Towards a robust CFD model for aeration tanks for sewage treatment - a lab-scale study by Karpinska, Anna M., Bridgeman, John

“…Detailed insight into the hydrodynamics of aeration tanks is of crucial importance for improvements in treatment efficiency, optimization of the process design…”
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Differential role of Th1 and Th2 cytokines in autotoxicity driven by CD19-specific second-generation chimeric antigen receptor T cells in a mouse model by Cheadle, Eleanor J, Sheard, Victoria, Rothwell, Dominic G, Bridgeman, John S, Ashton, Garry, Hanson, Vivien, Mansoor, A Wasat, Hawkins, Robert E, Gilham, David E

“…T cells engrafted with chimeric AgRs (CAR) are showing exciting potential for targeting B cell malignancies in early-phase clinical trials. To determine…”
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Mutational and structural analysis of KIR3DL1 reveals a lineage-defining allotypic dimorphism that impacts both HLA and peptide sensitivity by O'Connor, Geraldine M, Vivian, Julian P, Widjaja, Jacqueline M, Bridgeman, John S, Gostick, Emma, Lafont, Bernard A P, Anderson, Stephen K, Price, David A, Brooks, Andrew G, Rossjohn, Jamie, McVicar, Daniel W

“…Killer Ig-like receptors (KIRs) control the activation of human NK cells via interactions with peptide-laden HLAs. KIR3DL1 is a highly polymorphic inhibitory…”
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Dual Molecular Mechanisms Govern Escape at Immunodominant HLA A2-Restricted HIV Epitope by Cole, David K, Fuller, Anna, Dolton, Garry, Zervoudi, Efthalia, Legut, Mateusz, Miles, Kim, Blanchfield, Lori, Madura, Florian, Holland, Christopher J, Bulek, Anna M, Bridgeman, John S, Miles, John J, Schauenburg, Andrea J A, Beck, Konrad, Evavold, Brian D, Rizkallah, Pierre J, Sewell, Andrew K

“…Serial accumulation of mutations to fixation in the SLYNTVATL (SL9) immunodominant, HIV p17 Gag-derived, HLA A2-restricted cytotoxic T lymphocyte epitope…”
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ADAM17-dependent proteolysis of L-selectin promotes early clonal expansion of cytotoxic T cells by Mohammed, Rebar N., Wehenkel, Sophie C., Galkina, Elena V., Yates, Emma-Kate, Preece, Graham, Newman, Andrew, Watson, H. Angharad, Ohme, Julia, Bridgeman, John S., Durairaj, Ruban R. P., Moon, Owen R., Ladell, Kristin, Miners, Kelly L., Dolton, Garry, Troeberg, Linda, Kashiwagi, Masahide, Murphy, Gillian, Nagase, Hideaki, Price, David A., Matthews, R. James, Knäuper, Vera, Ager, Ann

“…L-selectin on T-cells is best known as an adhesion molecule that supports recruitment of blood-borne naïve and central memory cells into lymph nodes…”
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Transgenic T-cell receptor immunotherapy for cancer: building on clinical success by Oppermans, Natasha, Kueberuwa, Gray, Hawkins, Robert E., Bridgeman, John S.

“…With the advent of immunotherapy as a realistic and promising option for cancer treatment, adoptive cellular therapies are gaining significant interest in the…”
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Human CLEC9A antibodies deliver Wilms' tumor 1 (WT1) antigen to CD141+ dendritic cells to activate naïve and memory WT1‐specific CD8+ T cells by Pearson, Frances E, Tullett, Kirsteen M, Leal‐Rojas, Ingrid M, Haigh, Oscar L, Masterman, Kelly‐Anne, Walpole, Carina, Bridgeman, John S, McLaren, James E, Ladell, Kristin, Miners, Kelly, Llewellyn‐Lacey, Sian, Price, David A, Tunger, Antje, Schmitz, Marc, Miles, John J, Lahoud, Mireille H, Radford, Kristen J

“…Objectives Vaccines that prime Wilms' tumor 1 (WT1)‐specific CD8+ T cells are attractive cancer immunotherapies. However, immunogenicity and clinical response…”
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