Search Results - "Bricker, Kristen"

The mitochondrial sodium/calcium exchanger NCLX (Slc8b1) in B lymphocytes by Emrich, Scott M., Yoast, Ryan E., Fike, Adam J., Bricker, Kristen N., Xin, Ping, Zhang, Xuexin, Rahman, Ziaur S.M., Trebak, Mohamed

“…•NCLX has minor, if any, contribution to mitochondrial Ca2+ extrusion in B cells.•NCLX is required for optimal SOCE activity in B cells.•NCLX knockout does not…”
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STAT3 signaling in B cells controls germinal center zone organization and recycling by Fike, Adam J., Chodisetti, Sathi Babu, Wright, Nathaniel E., Bricker, Kristen N., Domeier, Phillip P., Maienschein-Cline, Mark, Rosenfeld, Aaron M., Luckenbill, Sara A., Weber, Julia L., Choi, Nicholas M., Luning Prak, Eline T., Mandal, Malay, Clark, Marcus R., Rahman, Ziaur S.M.

“…Germinal centers (GCs), sites of antibody affinity maturation, are organized into dark (DZ) and light (LZ) zones. Here, we show a B cell-intrinsic role for…”
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Orai3 and Orai1 mediate CRAC channel function and metabolic reprogramming in B cells by Emrich, Scott M, Yoast, Ryan E, Zhang, Xuexin, Fike, Adam J, Wang, Yin-Hu, Bricker, Kristen N, Tao, Anthony Y, Xin, Ping, Walter, Vonn, Johnson, Martin T, Pathak, Trayambak, Straub, Adam C, Feske, Stefan, Rahman, Ziaur S M, Trebak, Mohamed

“…The essential role of store-operated Ca entry (SOCE) through Ca release-activated Ca (CRAC) channels in T cells is well established. In contrast, the…”
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Context-Dependent miR-21 Regulation of TLR7-Mediated Autoimmune and Foreign Antigen-Driven Antibody-Forming Cell and Germinal Center Responses by Schell, Stephanie L, Bricker, Kristen N, Fike, Adam J, Chodisetti, Sathi Babu, Domeier, Phillip P, Choi, Nicholas M, Fasnacht, Melinda J, Luckenbill, Sara A, Ziegler, Steven F, Rahman, Ziaur S M

“…MicroRNAs (miRNAs) are involved in healthy B cell responses and the loss of tolerance in systemic lupus erythematosus (SLE), although the role of many miRNAs…”
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STAT4 Is Largely Dispensable for Systemic Lupus Erythematosus-like Autoimmune- and Foreign Antigen-Driven Antibody-Forming Cell, Germinal Center, and Follicular Th Cell Responses by Fike, Adam J, Chodisetti, Sathi Babu, Bricker, Kristen N, Choi, Nicholas M, Chroneos, Zissis C, Kaplan, Mark H, Rahman, Ziaur S M

“…Genome-wide association studies identified variants in the transcription factor gene and several other genes in the STAT4 signaling pathway, such as , , , and…”
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Strain-Dependent Contribution of MAVS to Spontaneous Germinal Center Responses by Schell, Stephanie L, Chodisetti, Sathi Babu, Fike, Adam J, Choi, Nicholas M, Bricker, Kristen N, Rahman, Ziaur S M

“…Germinal centers (GCs) are essential for the production of somatically hypermutated, class-switched Abs that are protective against infection, but they also…”
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miR-21 promotes B cell autoreactivity, inflammatory signaling, and metabolism in TLR7-driven systemic autoimmunity by Bricker, Kristen N, Fike, Adam J, Luckenbill, Sara A, Weber, Julia L, Jackson, Jasmine S, Olsen, Nancy J, Rahman, Ziaur

“…MicroRNA-21 (miR-21) is upregulated in SLE patients and promotes disease in multiple autoimmune mouse models; however, mechanisms by which miR-21 promote…”
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B cell-intrinsic STAT3 regulates the germinal center dark zone by Chodisetti, Sathi Babu, Fike, Adam, Bricker, Kristen, Domeier, Phillip P, Choi, Nicholas M, Rahman, Ziaur

“…Germinal centers (GCs) are sites for antibody diversification, somatic hypermutation (SHM) and antigen specific B cell selection. GCs are anatomically divided…”
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Evolutionary Landscape of SOX Genes to Inform Genotype-to-Phenotype Relationships by Underwood, Adam, Rasicci, Daniel T, Hinds, David, Mitchell, Jackson T, Zieba, Jacob K, Mills, Joshua, Arnold, Nicholas E, Cook, Taylor W, Moustaqil, Mehdi, Gambin, Yann, Sierecki, Emma, Fontaine, Frank, Vanderweele, Sophie, Das, Akansha S, Cvammen, William, Sirpilla, Olivia, Soehnlen, Xavier, Bricker, Kristen, Alokaili, Maram, Green, Morgan, Heeringa, Sadie, Wilstermann, Amy M, Freeland, Thomas M, Qutob, Dinah, Milsted, Amy, Jauch, Ralf, Triche, Jr, Timothy J, Krawczyk, Connie M, Bupp, Caleb P, Rajasekaran, Surender, Francois, Mathias, Prokop, Jeremy W

“…The SOX transcription factor family is pivotal in controlling aspects of development. To identify genotype-phenotype relationships of SOX proteins, we…”
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