Search Results - "Bricker, Barbara A"

The Mechanistic Targets of Antifungal Agents: An Overview by Mazu, Tryphon K, Bricker, Barbara A, Flores-Rozas, Hernan, Ablordeppey, Seth Y

“…Pathogenic fungi are a major causative group for opportunistic infections (OIs). AIDS patients and other immunocompromised individuals are at risk for OIs,…”
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Benzothieno[3,2-b]quinolinium and 3-(phenylthio)quinolinium compounds: Synthesis and evaluation against opportunistic fungal pathogens by Boateng, Comfort A., Eyunni, Suresh V.K., Zhu, Xue Y., Etukala, Jagan R., Bricker, Barbara A., Ashfaq, M.K., Jacob, Melissa R., Khan, Shabana I., Walker, Larry A., Ablordeppey, Seth Y.

“…Substitution around 5-methyl benzothieno[3,2-b]quinolinium (2) ring system was explored in order to identify positions of substitution that could improve its…”
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Evaluation of SYA16263 as a new potential antipsychotic agent without catalepsy by Bricker, Barbara A., Peprah, Kwame, Kang, Hye J., Ablordeppey, S.Y.

“…SYA16263 exhibited moderate radioligand binding affinity at the D2 receptor and produced inhibition of apomorphine-induced climbing behavior in mice with an…”
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A study of the structure-affinity relationship in SYA16263; is a D2 receptor interaction essential for inhibition of apormorphine-induced climbing behavior in mice? by Onyameh, Edem K., Bricker, Barbara A., Eyunni, Suresh V.K., Voshavar, Chandrashekhar, Gonela, Uma M., Ofori, Edward, Jenkins, Andrea, Ablordeppey, Seth Y.

“…[Display omitted] Dopamine (DA) and serotonin (5-HT) receptors are prime targets for the development of antipsychotics. The specific role of each receptor…”
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A study of the structure-affinity relationship in SYA16263; is a D 2 receptor interaction essential for inhibition of apormorphine-induced climbing behavior in mice? by Onyameh, Edem K, Bricker, Barbara A, Eyunni, Suresh V K, Voshavar, Chandrashekhar, Gonela, Uma M, Ofori, Edward, Jenkins, Andrea, Ablordeppey, Seth Y

“…Dopamine (DA) and serotonin (5-HT) receptors are prime targets for the development of antipsychotics. The specific role of each receptor subtype to the…”
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Enantioseparation of 5‐chloro‐2‐{2‐[3,4‐dihydroisoquinoline‐2(1H)‐yl]ethyl}‐2‐methyl‐2,3‐dihydro‐1H‐inden‐1‐one (SYA 40247), a high‐affinity 5‐HT7 receptor ligand, by HPLC–PDA using amylose tris‐(3, 5‐ dimethylphenylcarbamate) as a chiral stationary phase by Onyameh, Edem K., Bricker, Barbara A., Ofori, Edward, Ablordeppey, Seth Y.

“…In previous structure–activity relationship studies to identify new and selective 5‐HT7 receptor (5‐HT7R) ligands, we identified the chiral compound,…”
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Synthesis and evaluation of the structural elements in alkylated tetrahydroisoquinolines for binding to CNS receptors by Ofori, Edward, Zhu, Xue Y, Etukala, Jagan R, Bricker, Barbara A, Ablordeppey, Seth Y

“…Diseases of the CNS are often complex and involve multiple receptor systems and thus, the treatment options for these diseases must focus on targeting the…”
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Design and discovery of a high affinity, selective and β-arrestin biased 5-HT7 receptor agonist by Onyameh, Edem K., Ofori, Edward, Bricker, Barbara A., Gonela, Uma M., Eyunni, Suresh V. K., Kang, Hye J., Voshavar, Chandrashekar, Ablordeppey, Seth Y.

“…Compound 1c , 5-chloro-2-(2-(3,4-dihydroisoquinolin-2(1H)-yl)ethyl)-2,3-dihydro-1H-inden-1-one was previously reported from our laboratory showing high…”
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Design and synthesis of dual 5-HT1A and 5-HT7 receptor ligands by Ofori, Edward, Zhu, Xue Y., Etukala, Jagan R., Peprah, Kwakye, Jordan, Kamanski R., Adkins, Adia A., Bricker, Barbara A., Kang, Hye J., Huang, Xi-Ping, Roth, Bryan L., Ablordeppey, Seth Y.

“…[Display omitted] 5-HT1A and 5-HT7 receptors have been at the center of discussions recently due in part to their major role in the etiology of major central…”
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Enantiomeric Separation, Absolute Configuration by X‑ray Crystallographic Analysis, and Functional Evaluation of Enantiomers of the Dual Ligand, SYA0340 at 5‑HT1A and 5‑HT7A Receptors by Bricker, Barbara A., Voshavar, Chandrashekhar, Onyameh, Edem K., Gonela, Uma M., Lin, Xinsong, Swanson, Tracy L., Kozell, Laura B., Schmachtenberg, Jennifer L., Bloom, Shelley H., Janowsky, Aaron J., Ablordeppey, Seth Y.

“…We have previously identified 5-chloro-2-methyl-2-(3-(4-(pyridin-2-yl)­piperazin-1-yl)­propyl)-2,3-dihydro-1H-inden-1-one (SYA0340) as a dual 5-HT1A and 5-HT7…”
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Enantiomeric Separation, Absolute Configuration by X-ray Crystallographic Analysis, and Functional Evaluation of Enantiomers of the Dual Ligand, SYA0340 at 5-HT 1A and 5-HT 7A Receptors by Bricker, Barbara A, Voshavar, Chandrashekhar, Onyameh, Edem K, Gonela, Uma M, Lin, Xinsong, Swanson, Tracy L, Kozell, Laura B, Schmachtenberg, Jennifer L, Bloom, Shelley H, Janowsky, Aaron J, Ablordeppey, Seth Y

“…We have previously identified 5-chloro-2-methyl-2-(3-(4-(pyridin-2-yl)piperazin-1-yl)propyl)-2,3-dihydro-1 -inden-1-one (SYA0340) as a dual 5-HT and 5-HT…”
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Development of CNS multi-receptor ligands: Modification of known D2 pharmacophores by Etukala, Jagan R., Zhu, Xue Y., Eyunni, Suresh V.K., Onyameh, Edem K., Ofori, Edward, Bricker, Barbara A., Kang, Hye J., Huang, Xi-Ping, Roth, Bryan L., Ablordeppey, Seth Y.

“…[Display omitted] Several known D2 pharmacophores have been explored as templates for identifying ligands with multiple binding affinities at dopamine and…”
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Enantioseparation of 5‐chloro‐2‐{2‐[3,4‐dihydroisoquinoline‐2(1 H )‐yl]ethyl}‐2‐methyl‐2,3‐dihydro‐1 H ‐inden‐1‐one (SYA 40247), a high‐affinity 5‐HT 7 receptor ligand, by HPLC–PDA using amylose tris‐(3, 5‐ dimethylphenylcarbamate) as a chiral stationary phase by Onyameh, Edem K., Bricker, Barbara A., Ofori, Edward, Ablordeppey, Seth Y.

“…In previous structure–activity relationship studies to identify new and selective 5‐HT 7 receptor (5‐HT 7 R) ligands, we identified the chiral compound,…”
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Enantioseparation of 5-chloro-2-(2-(3,4-dihydroisoquinoline-2(1H)-yl)ethyl)-2-methyl-2,3-dihydro-1H-inden-1-one (SYA 40247), a high affinity 5-HT7 receptor ligand, by HPLC-PDA using amylose tris-(3, 5- dimethylphenylcarbamate) as a chiral stationary phase by Onyameh, Edem K., Bricker, Barbara A., Ofori, Edward, Ablordeppey, Seth Y.

“…In a previous structure activity relationship studies to identify new and selective 5-HT 7 receptor (5-HT 7 R) ligands, we have identified the chiral compound,…”
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Design and discovery of a high affinity, selective and β-arrestin biased 5-HT 7 Receptor Agonist by Onyameh, Edem K, Ofori, Edward, Bricker, Barbara A, Gonela, Uma M, Eyunni, Suresh V K, Kang, Hye J, Voshavar, Chandrashekar, Ablordeppey, Seth Y

“…Compound , 5-chloro-2-(2-(3,4-dihydroisoquinolin-2(1H)-yl)ethyl)-2,3-dihydro-1H-inden-1-one was previously reported from our laboratory showing high affinity…”
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Enantioseparation of 5-chloro-2-{2-[3,4-dihydroisoquinoline-2(1H)-yl]ethyl}-2-methyl-2,3-dihydro-1H-inden-1-one (SYA 40247), a high-affinity 5-HT 7 receptor ligand, by HPLC-PDA using amylose tris-(3, 5- dimethylphenylcarbamate) as a chiral stationary phase by Onyameh, Edem K, Bricker, Barbara A, Ofori, Edward, Ablordeppey, Seth Y

“…In previous structure-activity relationship studies to identify new and selective 5-HT receptor (5-HT R) ligands, we identified the chiral compound,…”
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