Search Results - "Brichard, Sonia M."

Circadian clock dysfunction in human omental fat links obesity to metabolic inflammation by Maury, Eleonore, Navez, Benoit, Brichard, Sonia M.

“…To unravel the pathogenesis of obesity and its complications, we investigate the interplay between circadian clocks and NF-κB pathway in human adipose tissue…”
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Adiponectin and Its Mimics on Skeletal Muscle: Insulin Sensitizers, Fat Burners, Exercise Mimickers, Muscling Pills … or Everything Together? by Abou-Samra, Michel, Selvais, Camille M, Dubuisson, Nicolas, Brichard, Sonia M

“…Adiponectin (ApN) is a hormone abundantly secreted by adipocytes and it is known to be tightly linked to the metabolic syndrome. It promotes…”
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Downregulation of the NLRP3 inflammasome by adiponectin rescues Duchenne muscular dystrophy by Boursereau, Raphaël, Abou-Samra, Michel, Lecompte, Sophie, Noel, Laurence, Brichard, Sonia M

“…The hormone adiponectin (ApN) exerts powerful anti-inflammatory effects on skeletal muscle and can reverse devastating myopathies, like Duchenne muscular…”
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AdipoRon enhances healthspan in middle‐aged obese mice: striking alleviation of myosteatosis and muscle degenerative markers by Selvais, Camille M., Davis‐López de Carrizosa, María A., Nachit, Maxime, Versele, Romain, Dubuisson, Nicolas, Noel, Laurence, Gillard, Justine, Leclercq, Isabelle A., Brichard, Sonia M., Abou‐Samra, Michel

“…Background Obesity among older adults has increased tremendously. Obesity accelerates ageing and predisposes to age‐related conditions and diseases, such as…”
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AdipoRon, a new therapeutic prospect for Duchenne muscular dystrophy by Abou‐Samra, Michel, Selvais, Camille M., Boursereau, Raphael, Lecompte, Sophie, Noel, Laurence, Brichard, Sonia M.

“…Background Adiponectin (ApN) is a hormone known to exhibit insulin‐sensitizing, fat‐burning, and anti‐inflammatory properties in several tissues, including the…”
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Potential Therapeutic Action of Adiponectin in Duchenne Muscular Dystrophy by Abou-Samra, Michel, Boursereau, Raphaël, Lecompte, Sophie, Noel, Laurence, Brichard, Sonia M

“…Adiponectin (ApN) is a hormone that exhibits anti-inflammatory effects on skeletal muscle exposed to acute and chronic inflammation. We have previously tested…”
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Inhibiting the inflammasome with MCC950 counteracts muscle pyroptosis and improves Duchenne muscular dystrophy by Dubuisson, Nicolas, Davis-López de Carrizosa, María A, Versele, Romain, Selvais, Camille M, Noel, Laurence, Van den Bergh, P Y D, Brichard, Sonia M, Abou-Samra, Michel

“…Duchenne muscular dystrophy (DMD) is the most common inherited human myopathy. Typically, the secondary process involving severe inflammation and necrosis…”
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Determinants of Early Atherosclerosis in Obese Children and Adolescents by Beauloye, Véronique, Zech, Francis, Tran Thi Mong, Hiep, Clapuyt, Philippe, Maes, Marc, Brichard, Sonia M.

“…Context: Obesity in childhood is associated with an increased mortality due to cardiovascular (CV) diseases in adulthood, independent of adult weight. Recent…”
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MicroRNAs Regulated by Adiponectin as Novel Targets for Controlling Adipose Tissue Inflammation by Ge, Qian, Gérard, Justine, Noël, Laurence, Scroyen, Ilse, Brichard, Sonia M

“…A low-grade proinflammatory state contributes to the metabolic syndrome (MS). Adiponectin (ApN), which is reduced in the MS, has emerged as a master regulator…”
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New targets to alleviate skeletal muscle inflammation: role of microRNAs regulated by adiponectin by Boursereau, Raphaël, Abou-Samra, Michel, Lecompte, Sophie, Noel, Laurence, Brichard, Sonia M.

“…Muscle inflammation worsens metabolic disorders as well as devastating myopathies. The hormone adiponectin (ApN) has emerged has a master regulator of…”
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Administration of adiponectin receptor agonist AdipoRon relieves cancer cachexia by mitigating inflammation in tumour‐bearing mice by Massart, Isabelle S., Kouakou, Axell‐Natalie, Pelet, Nathan, Lause, Pascale, Schakman, Olivier, Loumaye, Audrey, Abou‐Samra, Michel, Deldicque, Louise, Bindels, Laure B., Brichard, Sonia M., Thissen, Jean‐Paul

“…Background Cancer cachexia is a life‐threatening, inflammation‐driven wasting syndrome that remains untreatable. Adiponectin, the most abundant adipokine,…”
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Challenging Sarcopenia: Exploring AdipoRon in Aging Skeletal Muscle as a Healthspan-Extending Shield by Selvais, Camille M, Davis-López de Carrizosa, Maria A, Versele, Romain, Dubuisson, Nicolas, Noel, Laurence, Brichard, Sonia M, Abou-Samra, Michel

“…Sarcopenia, characterized by loss of muscle mass, quality, and function, poses significant risks in aging. We previously demonstrated that long-term treatment…”
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Walking down Skeletal Muscle Lane: From Inflammasome to Disease by Dubuisson, Nicolas, Versele, Romain, Davis-López de Carrizosa, María A, Selvais, Camille M, Brichard, Sonia M, Abou-Samra, Michel

“…Over the last decade, innate immune system receptors and sensors called inflammasomes have been identified to play key pathological roles in the development…”
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Adipokines identified as new downstream targets for adiponectin: lessons from adiponectin-overexpressing or -deficient mice by Ge, Qian, Ryken, Laurence, Noel, Laurence, Maury, Eléonore, Brichard, Sonia M

“…Adipokines play a central role in the pathogenesis of the metabolic syndrome. Among them, adiponectin (ApN), a master regulator of immune and fuel homeostasis,…”
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Overexpression of Adiponectin Targeted to Adipose Tissue in Transgenic Mice: Impaired Adipocyte Differentiation by Bauche, Isabelle B, El Mkadem, Samira Ait, Pottier, Anne-Marie, Senou, Maximin, Many, Marie-Christine, Rezsohazy, René, Penicaud, Luc, Maeda, Norikazu, Funahashi, Tohru, Brichard, Sonia M

“…Adiponectin (ApN) is an adipokine whose expression and plasma levels are inversely related to obesity and insulin-resistant states. Chronic repercussions of…”
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The Adiponectin Receptor Agonist, ALY688: A Promising Therapeutic for Fibrosis in the Dystrophic Muscle by Dubuisson, Nicolas, Versele, Romain, Davis-López de Carrizosa, Maria A, Selvais, Camille M, Noel, Laurence, Planchon, Chloé, Van den Bergh, Peter Y. K, Brichard, Sonia M, Abou-Samra, Michel

“…Duchenne muscular dystrophy (DMD) is one of the most devastating myopathies, where severe inflammation exacerbates disease progression. Previously, we…”
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Evaluation of the relationship between GPR43 and adiposity in human by Dewulf, Evelyne M, Ge, Qian, Bindels, Laure B, Sohet, Florence M, Cani, Patrice D, Brichard, Sonia M, Delzenne, Nathalie M

“…GPR43 is a G-protein-coupled receptor that participates in adipocyte differentiation in mice and is over-expressed in adipose tissue of obese mice. The aim of…”
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Local Induction of Adiponectin Reduces Lipopolysaccharide-Triggered Skeletal Muscle Damage by Jortay, Julie, Senou, Maximin, Delaigle, Aurélie, Noel, Laurence, Funahashi, Tohru, Maeda, Norikazu, Many, Marie C, Brichard, Sonia M

“…Adiponectin (ApN) exhibits metabolic and antiinflammatory properties. This hormone is exclusively secreted by adipocytes under normal conditions. We have shown…”
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Adiponectin downregulates its own production and the expression of its AdipoR2 receptor in transgenic mice by Bauche, Isabelle B., Ait El Mkadem, Samira, Rezsohazy, René, Funahashi, Tohru, Maeda, Norikazu, Miranda, Lisa Miranda, Brichard, Sonia M.

“…Adiponectin (ApN) is an adipokine whose expression and plasma levels are inversely related to obesity and insulin-resistant states. The in vivo effects of a…”
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Leptin treatment markedly increased plasma adiponectin but barely decreased plasma resistin of ob/ob mice by Delporte, Marie-Laure, El Mkadem, Samira Ait, Quisquater, Muriel, Brichard, Sonia M

“…Adiponectin (ApN) and leptin are two adipocytokines that control fuel homeostasis, body weight, and insulin sensitivity. Their interplay is still poorly…”
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