Search Results - "Brian MacKenna"

Case fatality risk of the SARS-CoV-2 variant of concern B.1.1.7 in England, 16 November to 5 February by Grint, Daniel J, Wing, Kevin, Williamson, Elizabeth, McDonald, Helen I, Bhaskaran, Krishnan, Evans, David, Evans, Stephen Jw, Walker, Alex J, Hickman, George, Nightingale, Emily, Schultze, Anna, Rentsch, Christopher T, Bates, Chris, Cockburn, Jonathan, Curtis, Helen J, Morton, Caroline E, Bacon, Sebastian, Davy, Simon, Wong, Angel Ys, Mehrkar, Amir, Tomlinson, Laurie, Douglas, Ian J, Mathur, Rohini, Blomquist, Paula, MacKenna, Brian, Ingelsby, Peter, Croker, Richard, Parry, John, Hester, Frank, Harper, Sam, DeVito, Nicholas J, Hulme, Will, Tazare, John, Goldacre, Ben, Smeeth, Liam, Eggo, Rosalind M

“…The SARS-CoV-2 B.1.1.7 variant of concern (VOC) is increasing in prevalence across Europe. Accurate estimation of disease severity associated with this VOC is…”
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Regional variations in the pharmacological management of narcolepsy in secondary care by Fred, van Someren, Fiona, Sun, Milan, Wiedemann, Brian, Mackenna, Sofia, Eriksson, Helen, Strongman

“…BackgroundSolriamfetol, Pitolisant, and Sodium Oxybate are relatively new, high-cost, treatments for Narcolepsy, prescribed initially in secondary care. There…”
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Severity of Severe Acute Respiratory System Coronavirus 2 (SARS-CoV-2) Alpha Variant (B.1.1.7) in England by Grint, Daniel J, Wing, Kevin, Houlihan, Catherine, Gibbs, Hamish P, Evans, Stephen J W, Williamson, Elizabeth, McDonald, Helen I, Bhaskaran, Krishnan, Evans, David, Walker, Alex J, Hickman, George, Nightingale, Emily, Schultze, Anna, Rentsch, Christopher T, Bates, Chris, Cockburn, Jonathan, Curtis, Helen J, Morton, Caroline E, Bacon, Sebastian, Davy, Simon, Wong, Angel Y S, Mehrkar, Amir, Tomlinson, Laurie, Douglas, Ian J, Mathur, Rohini, MacKenna, Brian, Ingelsby, Peter, Croker, Richard, Parry, John, Hester, Frank, Harper, Sam, DeVito, Nicholas J, Hulme, Will, Tazare, John, Smeeth, Liam, Goldacre, Ben, Eggo, Rosalind M

“…Abstract Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) alpha variant (B.1.1.7) is associated with higher transmissibility than…”
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Overall and cause-specific hospitalisation and death after COVID-19 hospitalisation in England: A cohort study using linked primary care, secondary care, and death registration data in the OpenSAFELY platform by Bhaskaran, Krishnan, Rentsch, Christopher T, Hickman, George, Hulme, William J, Schultze, Anna, Curtis, Helen J, Wing, Kevin, Warren-Gash, Charlotte, Tomlinson, Laurie, Bates, Chris J, Mathur, Rohini, MacKenna, Brian, Mahalingasivam, Viyaasan, Wong, Angel, Walker, Alex J, Morton, Caroline E, Grint, Daniel, Mehrkar, Amir, Eggo, Rosalind M, Inglesby, Peter, Douglas, Ian J, McDonald, Helen I, Cockburn, Jonathan, Williamson, Elizabeth J, Evans, David, Parry, John, Hester, Frank, Harper, Sam, Evans, Stephen Jw, Bacon, Sebastian, Smeeth, Liam, Goldacre, Ben

“…There is concern about medium to long-term adverse outcomes following acute Coronavirus Disease 2019 (COVID-19), but little relevant evidence exists. We aimed…”
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Factors associated with deaths due to COVID-19 versus other causes: population-based cohort analysis of UK primary care data and linked national death registrations within the OpenSAFELY platform by Bhaskaran, Krishnan, Bacon, Sebastian, Evans, Stephen JW, Bates, Chris J, Rentsch, Christopher T, MacKenna, Brian, Tomlinson, Laurie, Walker, Alex J, Schultze, Anna, Morton, Caroline E, Grint, Daniel, Mehrkar, Amir, Eggo, Rosalind M, Inglesby, Peter, Douglas, Ian J, McDonald, Helen I, Cockburn, Jonathan, Williamson, Elizabeth J, Evans, David, Curtis, Helen J, Hulme, William J, Parry, John, Hester, Frank, Harper, Sam, Spiegelhalter, David, Smeeth, Liam, Goldacre, Ben

“…Mortality from COVID-19 shows a strong relationship with age and pre-existing medical conditions, as does mortality from other causes. We aimed to investigate…”
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Trends in weight gain recorded in English primary care before and during the Coronavirus-19 pandemic: An observational cohort study using the OpenSAFELY platform by Samuel, Miriam, Park, Robin Y, Eastwood, Sophie V, Eto, Fabiola, Morton, Caroline E, Stow, Daniel, Bacon, Sebastian, Mehrkar, Amir, Morley, Jessica, Dillingham, Iain, Inglesby, Peter, Hulme, William J, Khunti, Kamlesh, Mathur, Rohini, Valabhji, Jonathan, MacKenna, Brian, Finer, Sarah

“…Obesity and rapid weight gain are established risk factors for noncommunicable diseases and have emerged as independent risk factors for severe disease…”
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Prescription of suboptimal statin treatment regimens: a retrospective cohort study of trends and variation in English primary care by Curtis, Helen J, Walker, Alex J, MacKenna, Brian, Croker, Richard, Goldacre, Ben

“…Background Since 2014 English national guidance recommends ‘high-intensity’ statins, reducing low-density lipoprotein (LDL) cholesterol by ≥40%. Aim To…”
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Risk of emergency hospital admission related to adverse events after antibiotic treatment in adults with a common infection: impact of COVID-19 and derivation and validation of risk prediction models by Zhong, Xiaomin, Palin, Victoria, Ashcroft, Darren M, Goldacre, Ben, MacKenna, Brian, Mehrkar, Amir, Bacon, Sebastian C J, Massey, Jon, Inglesby, Peter, Hand, Kieran, Pate, Alexander, van Staa, Tjeerd Pieter

“…With the global challenge of antimicrobial resistance intensified during the COVID-19 pandemic, evaluating adverse events (AEs) post-antibiotic treatment for…”
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Healthcare utilisation in people with long COVID: an OpenSAFELY cohort study by Lin, Liang-Yu, Henderson, Alasdair D, Carlile, Oliver, Dillingham, Iain, Butler-Cole, Ben F C, Marks, Michael, Briggs, Andrew, Jit, Mark, Tomlinson, Laurie A, Bates, Chris, Parry, John, Bacon, Sebastian C J, Goldacre, Ben, Mehrkar, Amir, MacKenna, Brian, Eggo, Rosalind M, Herrett, Emily

“…Long COVID potentially increases healthcare utilisation and costs. However, its impact on the NHS remains to be determined. This study aims to assess the…”
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Describing the population experiencing COVID-19 vaccine breakthrough following second vaccination in England: a cohort study from OpenSAFELY by Green, Amelia, Curtis, Helen, Hulme, William, Williamson, Elizabeth, McDonald, Helen, Bhaskaran, Krishnan, Rentsch, Christopher, Schultze, Anna, MacKenna, Brian, Mahalingasivam, Viyaasan, Tomlinson, Laurie, Walker, Alex, Fisher, Louis, Massey, Jon, Andrews, Colm, Hopcroft, Lisa, Morton, Caroline, Croker, Richard, Morley, Jessica, Mehrkar, Amir, Bacon, Seb, Evans, David, Inglesby, Peter, Hickman, George, Ward, Tom, Davy, Simon, Mathur, Rohini, Tazare, John, Eggo, Rosalind, Wing, Kevin, Wong, Angel, Forbes, Harriet, Bates, Chris, Cockburn, Jonathan, Parry, John, Hester, Frank, Harper, Sam, Douglas, Ian, Evans, Stephen, Smeeth, Liam, Goldacre, Ben

“…While the vaccines against COVID-19 are highly effective, COVID-19 vaccine breakthrough is possible despite being fully vaccinated. With SARS-CoV-2 variants…”
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Using Data to Improve Healthcare: A Case Study of Pancreatic Enzyme Replacement in Pancreatic Cancer by Varghese, Teena S, Andrews, Colm, Fisher, Louis, Goldacre, Ben, Mehrkar, Amir, Pande, Rupaly, Smith, Nadia A S, Walker, Alex J, Roberts, Keith J, Sultana, Asma, MacKenna, Brian, Lemanska, Agnieszka

“…In the UK, guidelines recommend pancreatic enzyme replacement therapy (PERT) to all people with unresectable pancreatic cancer. In 2023, we published a…”
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Trends in inequalities in avoidable hospitalisations across the COVID-19 pandemic: a cohort study of 23.5 million people in England by Green, Mark Alan, McKee, Martin, Massey, Jon, Mackenna, Brian, Mehrkar, Amir, Bacon, Seb, Macleod, John, Sheikh, Aziz, Shah, Syed Ahmar, Katikireddi, Srinivasa Vittal

“…ObjectiveTo determine whether periods of disruption were associated with increased ‘avoidable’ hospital admissions and wider social inequalities in…”
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OpenSAFELY: Representativeness of electronic health record platform OpenSAFELY-TPP data compared to the population of England by Andrews, Colm, Schultze, Anna, Curtis, Helen, Hulme, William, Tazare, John, Evans, Stephen, Mehrkar, Amir, Bacon, Sebastian, Hickman, George, Bates, Christopher, Parry, John, Hester, Frank, Harper, Sam, Cockburn, Jonathan, Evans, David, Ward, Tom, Davy, Simon, Inglesby, Peter, Goldacre, Ben, MacKenna, Brian, Tomlinson, Laurie, Walker, Alex

“…Since its inception in March 2020, data from the OpenSAFELY-TPP electronic health record platform has been used for more than 20 studies relating to the global…”
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Consistency, completeness and external validity of ethnicity recording in NHS primary care records: a cohort study in 25 million patients' records at source using OpenSAFELY by Andrews, Colm D, Mathur, Rohini, Massey, Jon, Park, Robin, Curtis, Helen J, Hopcroft, Lisa, Mehrkar, Amir, Bacon, Seb, Hickman, George, Smith, Rebecca, Evans, David, Ward, Tom, Davy, Simon, Inglesby, Peter, Dillingham, Iain, Maude, Steven, O'Dwyer, Thomas, Butler-Cole, Ben F C, Bridges, Lucy, Bates, Chris, Parry, John, Hester, Frank, Harper, Sam, Cockburn, Jonathan, Goldacre, Ben, MacKenna, Brian, Tomlinson, Laurie A, Walker, Alex J, Hulme, William J

“…Ethnicity is known to be an important correlate of health outcomes, particularly during the COVID-19 pandemic, where some ethnic groups were shown to be at…”
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Impact of first UK COVID-19 lockdown on hospital admissions: Interrupted time series study of 32 million people by Shah, Syed Ahmar, Brophy, Sinead, Kennedy, John, Fisher, Louis, Walker, Alex, Mackenna, Brian, Curtis, Helen, Inglesby, Peter, Davy, Simon, Bacon, Seb, Goldacre, Ben, Agrawal, Utkarsh, Moore, Emily, Simpson, Colin R, Macleod, John, Cooksey, Roxane, Sheikh, Aziz, Katikireddi, Srinivasa Vittal

“…Uncontrolled infection and lockdown measures introduced in response have resulted in an unprecedented challenge for health systems internationally. Whether…”
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Mortality among Care Home Residents in England during the first and second waves of the COVID-19 pandemic: an observational study of 4.3 million adults over the age of 65 by Schultze, Anna, Nightingale, Emily, Evans, David, Hulme, William, Rosello, Alicia, Bates, Chris, Cockburn, Jonathan, MacKenna, Brian, Curtis, Helen J, Morton, Caroline E, Croker, Richard, Bacon, Seb, McDonald, Helen I, Rentsch, Christopher T, Bhaskaran, Krishnan, Mathur, Rohini, Tomlinson, Laurie A, Williamson, Elizabeth J, Forbes, Harriet, Tazare, John, Grint, Daniel, Walker, Alex J, Inglesby, Peter, DeVito, Nicholas J, Mehrkar, Amir, Hickman, George, Davy, Simon, Ward, Tom, Fisher, Louis, Green, Amelia CA, Wing, Kevin, Wong, Angel YS, McManus, Robert, Parry, John, Hester, Frank, Harper, Sam, Evans, Stephen JW, Douglas, Ian J, Smeeth, Liam, Eggo, Rosalind M, Goldacre, Ben, Leon, David A

“…Residents in care homes have been severely impacted by COVID-19. We describe trends in the mortality risk among residents of care homes compared to private…”
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Impacts of the COVID-19 pandemic on deprivation-level differences in cardiovascular hospitalisations: a comparison of England and Denmark using the OpenSAFELY platform and National Registry Data by Costello, Ruth E, Pedersen, Lars, Henderson, Alasdair D, Tazare, John, Sorensen, Henrik Toft, Vandenbroucke, Jan P, Mansfield, Kathryn E, Mahalingasivam, Viyaasan, Zheng, Bang, Carreira, Helena, Bidulka, Patrick, Piehlmaier, Dominik Manuel, Wong, Angel Yun Sum, Warren-Gash, Charlotte, Hayes, Joseph F, Quint, Jennifer K, Katikireddi, Srinivasa Vittal, Mackenna, Brian, Mehrkar, Amir, Bacon, Sebastian, Goldacre, Ben, Tomlinson, Laurie A, Langan, Sinead M, Mathur, Rohini, Collaborative, The LH&W NCS (or CONVALESCENCE), Consortium, The OpenSAFELY

“…ObjectivesTo examine the impact of the COVID-19 pandemic on deprivation-related inequalities in hospitalisations for cardiovascular disease (CVD) conditions in…”
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Healthcare in England was affected by the COVID-19 pandemic across the pancreatic cancer pathway: A cohort study using OpenSAFELY-TPP by Lemanska, Agnieszka, Andrews, Colm, Fisher, Louis, Bacon, Seb, Frampton, Adam E, Mehrkar, Amir, Inglesby, Peter, Davy, Simon, Roberts, Keith, Patalay, Praveetha, Goldacre, Ben, MacKenna, Brian, Walker, Alex J

“…Healthcare across all sectors, in the UK and globally, was negatively affected by the COVID-19 pandemic. We analysed healthcare services delivered to people…”
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Eleven key measures for monitoring general practice clinical activity during COVID-19: A retrospective cohort study using 48 million adults' primary care records in England through OpenSAFELY by Fisher, Louis, Curtis, Helen J, Croker, Richard, Wiedemann, Milan, Speed, Victoria, Wood, Christopher, Brown, Andrew, Hopcroft, Lisa E M, Higgins, Rose, Massey, Jon, Inglesby, Peter, Morton, Caroline E, Walker, Alex J, Morley, Jessica, Mehrkar, Amir, Bacon, Seb, Hickman, George, Macdonald, Orla, Lewis, Tom, Wood, Marion, Myers, Martin, Samuel, Miriam, Conibere, Robin, Baqir, Wasim, Sood, Harpreet, Drury, Charles, Collison, Kiren, Bates, Chris, Evans, David, Dillingham, Iain, Ward, Tom, Davy, Simon, Smith, Rebecca M, Hulme, William, Green, Amelia, Parry, John, Hester, Frank, Harper, Sam, Cockburn, Jonathan, O'Hanlon, Shaun, Eavis, Alex, Jarvis, Richard, Avramov, Dima, Griffiths, Paul, Fowles, Aaron, Parkes, Nasreen, MacKenna, Brian, Goldacre, Ben

“…The COVID-19 pandemic has had a significant impact on delivery of NHS care. We have developed the OpenSAFELY Service Restoration Observatory (SRO) to develop…”
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The Use of Online Consultation Systems or Remote Consulting in England Characterized Through the Primary Care Health Records of 53 Million People in the OpenSAFELY Platform: Retrospective Cohort Study by Fonseca, Martina, MacKenna, Brian, Mehrkar, Amir, Walters, Caroline E, Hickman, George, Pearson, Jonathan, Fisher, Louis, Inglesby, Peter, Bacon, Seb, Davy, Simon, Hulme, William, Goldacre, Ben, Koffman, Ofra, Bakhai, Minal

“…The National Health Service (NHS) Long Term Plan, published in 2019, committed to ensuring that every patient in England has the right to digital-first primary…”
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