Search Results - "Brian Dyer, R"

Acceleration of catalysis in dihydrofolate reductase by transient, site-specific photothermal excitation by Kozlowski, Rachel, Zhao, Jing, Dyer, R. Brian

“…We have studied the role of protein dynamics in chemical catalysis in the enzyme dihydrofolate reductase (DHFR), using a pump–probe method that employs…”
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CO2 Reduction Catalyzed by Mercaptopteridine on Glassy Carbon by Xiang, Dongmei, Magana, Donny, Dyer, R. Brian

“…The catalytic reduction of CO2 is of great current interest because of its role in climate change and the energy cycle. We report a pterin electrocatalyst,…”
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Heterogeneity in the Folding of Villin Headpiece Subdomain HP36 by Nagarajan, Sureshbabu, Xiao, Shifeng, Raleigh, Daniel P, Dyer, R. Brian

“…Small single domain proteins that fold on the microsecond time scale have been the subject of intense interest as models for probing the complexity of folding…”
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Dynamics of hemagglutinin-mediated membrane fusion by Dyer, R. Brian, Eller, Micah W.

“…Importance of Membrane Fusion in Biology Membrane fusion is ubiquitous in biology, both in natural cellular functions such as neurotransmission and in…”
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Anisotropic energy flow and allosteric ligand binding in albumin by Li, Guifeng, Magana, Donny, Dyer, R. Brian

“…Allosteric interactions in proteins generally involve propagation of local structural changes through the protein to a remote site. Anisotropic energy…”
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Shape-Shifting Peptide Nanomaterials: Surface Asymmetry Enables pH-Dependent Formation and Interconversion of Collagen Tubes and Sheets by Merg, Andrea D, Touponse, Gavin, Genderen, Eric van, Blum, Thorsten B, Zuo, Xiaobing, Bazrafshan, Alisina, Siaw, Hew Ming Helen, McCanna, Arthur, Brian Dyer, R, Salaita, Khalid, Abrahams, Jan Pieter, Conticello, Vincent P

“…The fabrication of dynamic, transformable biomaterials that respond to environmental cues represents a significant step forward in the development of synthetic…”
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Localized Nanoscale Heating Leads to Ultrafast Hydrogel Volume-Phase Transition by Zhao, Jing, Su, Hanquan, Vansuch, Gregory E, Liu, Zheng, Salaita, Khalid, Dyer, R. Brian

“…The rate of the volume-phase transition for stimuli-responsive hydrogel particles ranging in size from millimeters to nanometers is limited by the rate of…”
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Proton-Coupled Electron Transfer Dynamics in the Catalytic Mechanism of a [NiFe]-Hydrogenase by Greene, Brandon L, Wu, Chang-Hao, McTernan, Patrick M, Adams, Michael W. W, Dyer, R. Brian

“…The movement of protons and electrons is common to the synthesis of all chemical fuels such as H2. Hydrogenases, which catalyze the reversible reduction of…”
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Applications of Photogating and Time Resolved Spectroscopy to Mechanistic Studies of Hydrogenases by Greene, Brandon L, Vansuch, Gregory E, Chica, Bryant C, Adams, Michael W. W, Dyer, R. Brian

“…Conspectus Rapid and facile redox chemistry is exemplified in nature by the oxidoreductases, the class of enzymes that catalyze electron transfer (ET) from a…”
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Site-Specific Tryptophan Labels Reveal Local Microsecond-Millisecond Motions of Dihydrofolate Reductase by Vaughn, Morgan B, Biren, Chloe, Li, Qun, Ragupathi, Ashwin, Dyer, R Brian

“…Many enzymes are known to change conformations during their catalytic cycle, but the role of these protein motions is not well understood. dihydrofolate…”
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Fast Helix Formation in the B Domain of Protein A Revealed by Site-Specific Infrared Probes by Davis, Caitlin M, Cooper, A. Kat, Dyer, R. Brian

“…Comparison of experimental and computational protein folding studies can be difficult because of differences in structural resolution. Isotope-edited infrared…”
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Glutamate Gated Proton-Coupled Electron Transfer Activity of a [NiFe]-Hydrogenase by Greene, Brandon L, Vansuch, Gregory E, Wu, Chang-Hao, Adams, Michael W. W, Dyer, R. Brian

“…[NiFe] hydrogenases are metalloenzymes that catalyze the reversible oxidation of H2. While electron transfer to and from the active site is understood to occur…”
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Catalytic Deoxyribozyme-Modified Nanoparticles for RNAi-Independent Gene Regulation by Yehl, Kevin, Joshi, Jayashree P, Greene, Brandon L, Dyer, R. Brian, Nahta, Rita, Salaita, Khalid

“…DNAzymes are catalytic oligonucleotides with important applications in gene regulation, DNA computing, responsive soft materials, and ultrasensitive metal-ion…”
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Quantum Dots Encapsulated within Phospholipid Membranes: Phase-Dependent Structure, Photostability, and Site-Selective Functionalization by Zheng, Weiwei, Liu, Yang, West, Ana, Schuler, Erin E, Yehl, Kevin, Dyer, R. Brian, Kindt, James T, Salaita, Khalid

“…Lipid vesicle encapsulation is an efficient approach to transfer quantum dots (QDs) into aqueous solutions, which is important for renewable energy…”
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Direct Observation and Control of Ultrafast Photoinduced Twisted Intramolecular Charge Transfer (TICT) in Triphenyl-Methane Dyes by Li, Guifeng, Magana, Donny, Dyer, R. Brian

“…Femtosecond time-resolved infrared spectroscopy was employed to study intramolecular charge transfer in triphenylmethane dyes, including malachite green (MG),…”
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Photoinduced Electron Transfer in Folic Acid Investigated by Ultrafast Infrared Spectroscopy by Li, Guifeng, Magana, Donny, Dyer, R. Brian

“…Conformational control of excited-state intramolecular electron transfer (ET) in folic acid (FA) has been investigated using femtosecond time-resolved infrared…”
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Azidohomoalanine: A Conformationally Sensitive IR Probe of Protein Folding, Protein Structure, and Electrostatics by Taskent-Sezgin, Humeyra, Chung, Juah, Banerjee, Partha S, Nagarajan, Sureshbabu, Dyer, R. Brian, Carrico, Isaac, Raleigh, Daniel P

“…Highly sensitive: The azido analogue of methionine, azidohomoalanine (see picture), is shown to be a sensitive IR probe of protein structure, folding, and…”
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Differential Ordering of the Protein Backbone and Side Chains during Protein Folding Revealed by Site-Specific Recombinant Infrared Probes by Nagarajan, Sureshbabu, Taskent-Sezgin, Humeyra, Parul, Dzmitry, Carrico, Isaac, Raleigh, Daniel P, Dyer, R. Brian

“…The time scale for ordering of the polypeptide backbone relative to the side chains is a critical issue in protein folding. The interplay between ordering of…”
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The Dynamical Nature of Enzymatic Catalysis by Callender, Robert, Dyer, R. Brian

“…As is well-known, enzymes are proteins designed to accelerate specific life essential chemical reactions by many orders of magnitude. A folded protein is a…”
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A simple three-dimensional-focusing, continuous-flow mixer for the study of fast protein dynamics by Burke, Kelly S, Parul, Dzmitry, Reddish, Michael J, Dyer, R Brian

“…We present a simple, yet flexible microfluidic mixer with a demonstrated mixing time as short as 80 μs that is widely accessible because it is made of…”
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